scholarly journals Cost-Effectiveness of Hypochlorous Acid Preserved Wound Cleanser versus Saline Irrigation in Conjunction with Ultrasonic Debridement for Complex Wounds

2021 ◽  
Vol 8 (2) ◽  
pp. 76-81
Author(s):  
Peter J. Mallow ◽  
John M. Hiebert ◽  
Martin C. Robson

Objective: Low-frequency ultrasound debridement with irrigation is an effective method of wound bed preparation. A recent clinical study compared hypochlorous acid preserved wound cleanser (HAPWOC) to saline and found HAPWOC to be a more effective adjunct to low frequency ultrasound debridement. However, HAPWOC has an added cost. The primary objective of this study was to assess the cost-effectiveness of HAPWOC as an irrigation modality with low-frequency ultrasound debridement for the treatment of severely complex wounds that were destined to be closed primarily via a flap. The secondary objective of this study was to estimate the number needed to treat (NNT) to avoid a wound-related complication and its expected cost per NNT. Methods: A patient-level Monte-Carlo simulation model was used to conduct a cost-effectiveness analysis from the US health system perspective. All clinical data were obtained from a prospective clinical trial. Cost data were obtained from the publicly available data sources in 2021 US dollars. The effect measure was the avoidance of wound-related complications at 14-days post-debridement. The primary outcome was the incremental cost-effectiveness ratio (ICER), a measure of the additional cost per benefit. The secondary outcomes were the NNT and expected cost per NNT to avoid one complication (complementary to the ICER in assessing cost-effectiveness). Deterministic and probabilistic sensitivity analyses (PSA) were performed to gauge the robustness and reliability of the results. Results: The ICER for HAPWOC versus saline irrigation was US$90.85 per wound complication avoided. The expected incremental cost per patient in the study and effect was US$49.97 with 55% relative reduction in wound-related complications at day 14 post debridement procedure. The NNT and cost per NNT were 2 and US$99.94, respectively. Sensitivity analyses demonstrated that these results were robust to variation in model parameters. Conclusion: HAPWOC was a cost-effective strategy for the treatment of complex wounds during ultrasonic debridement. For every two patients treated with HAPWOC, one complication was avoided.

2020 ◽  
pp. 13-23
Author(s):  
Natalya Kornova ◽  
A. Krylov

The article presents results of a study on the effectiveness of using lowfrequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis. The study involved 69 people aged 18 to 55 years: 39 (56.83 %) women and 30 (45.11 %) men with chronic rhinosinusitis during the period of clinical exacerbation and concomitant chronic tonsillitis without exacerbation. All patients included in the study underwent X-ray examination or computed tomography and magnetic resonance imaging of the paranasal sinuses. 100 % of the patients were examined for the presence of antibodies to Human gammaherpesvirus 4 (ELISA), had study of blood serum for IgM and IgG and test to determine the avidity of Ig G antibodies to γ-herpesviruses. The obtained data indicate the effectiveness of including low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic rhinosinusitis and concomitant chronic tonsillitis of bacterial and viral nature without exacerbation.


Author(s):  
Mohd Razealy Anuar ◽  
Mohamed Hussein Abdurahman ◽  
Nor Irwin Basir ◽  
Ahmad Zuhairi Abdullah

2003 ◽  
Vol 29 (5) ◽  
pp. S120-S121
Author(s):  
S. Bashardoust Tajali ◽  
S. Kazemi ◽  
A. Azari ◽  
A. Shahverdi ◽  
M. Jabal Ameli

2017 ◽  
Vol 284 ◽  
pp. 92-99 ◽  
Author(s):  
M. Bellardita ◽  
H.A. El Nazer ◽  
V. Loddo ◽  
F. Parrino ◽  
A.M. Venezia ◽  
...  

2014 ◽  
Vol 239 (6) ◽  
pp. 747-757 ◽  
Author(s):  
Zhi-Yong Shen ◽  
Gan-Lin Xia ◽  
Ming-Feng Wu ◽  
Min-Xin Shi ◽  
Fu-Lin Qiang ◽  
...  

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