Comparison of D-Dimer Activity and Residual Particle Size Produced Following Thrombus Disruption by Perfluorocarbon Containing Microbubbles Versus Urokinase in the Presence of Low Frequency Ultrasound

The application of various nanocarrier systems was widely explored in the field of pharmaceuticals to achieve better drug encapsulation and delivery. The aim of this study was to encapsulate lidocaine in alginate-based o/w nanocarriers based on the type of oil (i.e., solid or liquid), using a nanoemulsion template prepared by ultrasound-assisted phase inversion temperature (PIT) approach. The nanoemulsion template was initially prepared by dissolving lidocaine in the oil phase and surfactant and alginate in the aqueous phase, and keeping the PIT at around 85 °C, accompanied by gradual water dilution at 25 °C, to initiate the formation of nanoparticles (o/w) with the aid of low frequency ultrasound. The composition and concentration of the oil phase had a major impact on the particle size and led to an increase in the size of the droplet. The lipids that showed a higher drug solubility also showed higher particle size. On the other hand, increasing the concentration of surfactant decreases the size of the droplet before the concentration of the surfactant exceeds the limit, after which the size of the particle increases due to the aggregates that could be produced from the excess surfactant. The method used produced nanoemulsions that maintained nano-sized droplets < 50 nm, over long-term storage. Our findings are important for the design of nanocarrier systems for the encapsulation of lipophilic molecules.

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High-Intensity Low-Frequency Ultrasonic Treatment of Sulfated Polysaccharide from Brown Algae

Journal of Siberian Federal University Chemistry ◽

10.17516/1998-2836-0265 ◽

2021 ◽

Vol 14 (4) ◽

pp. 582-592

Author(s):

Viktoria E. Suprunchuk ◽

Keyword(s):

Particle Size ◽

Ultrasonic Treatment ◽

High Intensity ◽

Brown Algae ◽

Low Frequency ◽

Sulfated Polysaccharide ◽

Sulfated Polysaccharides ◽

Hydrodynamic Diameter ◽

Low Frequency Ultrasound ◽

Frequency Ultrasound

This paper reports on an effective method for depolymerization of fucoidan in an aqueous medium using ultrasonic treatment. To assess the effect of this treatment, high-molecular-weight fucoidan was dispersed at a concentration of 10 mg/ml in deionized water and subjected to ultrasound at a frequency of 20 kHz with varying intensity. The effect of high-intensity low-frequency ultrasound on the particle size of sulfated polysaccharides isolated from brown algae, where the minimum value of the average hydrodynamic diameter was 85.92 ± 32.9 nm, was studied. The dependence of the particle size of the polysaccharide on the intensity of ultrasonic exposure was revealed. The influence of this effect on the degree of sulfation of fucoidan has been determined. Shown the cavitation activity in the processing environment and discussed the reasons for its change

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Low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis

Terapevt (General Physician) ◽

10.33920/med-12-2003-02 ◽

2020 ◽

pp. 13-23

Author(s):

Natalya Kornova ◽

A. Krylov

Keyword(s):

Chronic Rhinosinusitis ◽

Low Frequency ◽

Chronic Tonsillitis ◽

Complex Treatment ◽

Resonance Imaging ◽

X Ray ◽

Low Frequency Ultrasound ◽

Viral Nature ◽

Ig G ◽

Frequency Ultrasound

The article presents results of a study on the effectiveness of using lowfrequency ultrasound and photochromotherapy in the complex treatment of patients with chronic bacterial and viral rhinosinusitis. The study involved 69 people aged 18 to 55 years: 39 (56.83 %) women and 30 (45.11 %) men with chronic rhinosinusitis during the period of clinical exacerbation and concomitant chronic tonsillitis without exacerbation. All patients included in the study underwent X-ray examination or computed tomography and magnetic resonance imaging of the paranasal sinuses. 100 % of the patients were examined for the presence of antibodies to Human gammaherpesvirus 4 (ELISA), had study of blood serum for IgM and IgG and test to determine the avidity of Ig G antibodies to γ-herpesviruses. The obtained data indicate the effectiveness of including low-frequency ultrasound and photochromotherapy in the complex treatment of patients with chronic rhinosinusitis and concomitant chronic tonsillitis of bacterial and viral nature without exacerbation.

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