Vitamin D levels in patients with diabetes mellitus in combination with chronic kidney disease

2021 ◽  
Vol 25 (6) ◽  
pp. 81-86
Author(s):  
A. P. Lichacheva ◽  
N. V. Agranovich ◽  
A. T. Klassova ◽  
A. S. Anopchenko ◽  
E. L. Solovyova
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Metabolic Effects ◽  
Control Group ◽  
Excretory Function ◽  
Vitamin D Levels ◽  
Wide Range ◽  
Patients With Diabetes

BACKGROUND. Vitamin D has been known since 1928. The wide range of its metabolic effects paradoxically contrasts with the high prevalence of insufficiency and deficiency in the population of different regions of the world. A number of publications have demonstrated information about the relationship between vitamin D and insulin production by beta cells of the pancreas, as well as the excretory function of the kidneys.THE AIM: to assess the level of vitamin D in patients with diabetes mellitus in combination with chronic kidney disease (CKD).PATIENTS AND METHODS. A questionnaire and a study of the level of 25-hydroxyvitamin D, creatinine, urea, and glucose in the blood were conducted in 117 patients aged 18 to 84 years who gave voluntary consent. All patients were divided into three study groups: group 1 - patients with long-term DM, group 2 - patients with newly diagnosed DM, and 3 - control group. The glomerular filtration rate (GFR) is calculated by the formula CKD-EPI.RESULTS. As a result of the study, it was found that patients with DM, regardless of the duration of its course, were more likely to suffer from vitamin D deficiency, compared with the control group, where D-deficiency and D-deficiency occurred with the same frequency. In addition, patients with DM were more likely to have stage 2-3A CKD, in contrast to the control group, where preserved kidney function prevailed. We also identified and confirmed the direct dependence of GFR on the level of vitamin D in the blood of patients with DM.CONCLUSION. In the patients studied by us, a clear association was found between a lower vitamin D index in the blood serum and the presence of a history of diabetes. They also showed a tendency to decrease the excretory function of the kidneys and the formation of CKD. Consequently, a full-fledged diagnosis of vitamin D-deficient conditions and timely initiated therapy can prevent or at least slow down the progression of CKD in these patients, which will certainly improve their quality of life and reduce the costs of health services for renal replacement therapy and rehabilitation of this group of patients.

scholarly journals Creating an arteriovenous fistula in patients with chronic kidney disease stage 5

2015 ◽  
Vol 96 (3) ◽  
pp. 298-302
Author(s):  
I V Zakieva ◽  
M V Timerbulatov ◽  
T R Galimov ◽  
S R Tuysin
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Arteriovenous Fistula ◽  
Main Group ◽  
Disease Stage ◽  
Control Group ◽  
Chronic Glomerulonephritis ◽  
Patients With Diabetes

Aim. Comparative assessment of microsurgical and traditional methods for creating an arteriovenous fistula for long-term hemodialysis in patients with chronic renal failure.Methods. Results of arteriovenous fistula surgeries for creating arteriovenous fistula for long-term hemodialysis in 169 patients with chronic renal failure in the period from 2008 to 2013 were analyzed. The main group included 87 patients in whom arteriovenous fistula was formed by microsurgery. For fistula thrombosis prophylaxis, 40 mg of nadroparin calcium (fraxiparine) was used in this group after surgery as a postoperative bolus, followed by 7 days subcutaneous administration. Arteriovenous fistula in patients of the main group underwent anti-thrombogenic treatment: paravasal tissues and vessel outside were irrigated by 1% sodium chloride methylthioninium (methylene blue) after the main phase of the operation, followed by lysine acetylsalicylate standard solution after 2 minutes. The control group included 82 patients in whom fistula was created conventionally without using microsurgical techniques. For arteriovenous fistula thrombosis prevention, 5000 IU of sodium heparin was used 4 times a day in patients of the control group.Results. In the main group, five cases of fistula thrombosis were observed in patients with diabetes mellitus and two in patients with chronic glomerulonephritis. In the control group, arteriovenous fistula thrombosis in the early postoperative period was recorded in 13 patients with diabetes mellitus, in four - with chronic glomerulonephritis, and in one - with polycystic kidney disease. In one (1.15%) patient of the main group and in three (3.66%) in the control group, wound infection associated with inflammatory processes development at the surgical wound was noted.Conclusion. Microsurgical formation of arteriovenous fistula in patients with terminal stage of chronic kidney disease is the method of choice (especially with concomitant diabetes mellitus), allowing to significantly reduce the risk for arteriovenous fistula thrombosis and therefore reduce the number of unsatisfactory results.

scholarly journals Vitamin D (25 ( OH) D ) in patients with chronic kidney disease stages 2-5

2016 ◽  
pp. 160-166 ◽  
Author(s):  
César Augusto Restrepo Valencia ◽  
Jose Vicente Aguirre Arango
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Statistical Methods ◽  
Laboratory Tests ◽  
Chronic Kidney Disease Stage ◽  
Sun Exposure ◽  
Disease Stage ◽  
Disease Etiology ◽  
Vitamin D Levels

Objective: To determine whether patients with chronic kidney disease (CKD) without dialysis their stage impacts the native vitamin D levels. Methods: Patients over 18 years with chronic kidney disease stage 2-5 without dialysis treatment. They demographic, anthropometric variables, degree of sun exposure, disease etiology and laboratory variables related to bone and mineral disorders were evaluated. Study analytical cross-sectional prospective. Descriptive statistical methods for quantitative and qualitative are characterized, and analytical correlation between levels of vitamin D statistical laboratory tests related to bone and mineral disorders, sun exposure and ethnicity variables for each stage were characterized. By descriptive statistical methods, quantitative and qualitative variables were characterized, and analytical statistical correlation between levels of vitamin D with laboratory tests related to bone and mineral disorders, sun exposure and ethnicity for each stage were practiced. Results: 331 patients were evaluated, with a mean age of 71 years, the mestizo majority (71%), 173 women, main etiology of CKD hypertensive nephropathy (33.2%). 21.1% of patients had normal levels of vitamin D, 70.1% insufficient, and 8.8% in deficit. Negative correlation was detected between the levels of vitamin 25(OH)D and serum creatinine, phosphorus, calcium x phosphorus product, PTH, proteins in urine 24 hours and BMI. Positive correlation for calcium and albumin. Positive statistical significance between the levels of vitamin 25(OH)D and sun exposure for 3b and 4 stages was found. Conclusions: In patients with CKD is common to detect low levels of vitamin 25(OH)D, which can contribute to the generation of secondary hyperparathyroidism.

scholarly journals Vitamin D Levels in Chronic Kidney Disease Stage 3, 4, and 5

2018 ◽  
Vol 5 (4) ◽  
pp. 168-174
Author(s):  
David Kristianus ◽  
Rudi Supriyadi ◽  
Siska Wiramihardja
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Vitamin D Levels

scholarly journals IMPACT OF CHRONIC KIDNEY DISEASE ON PLATELET P2Y12 RECEPTOR SIGNALING IN PATIENTS WITH DIABETES MELLITUS

2015 ◽  
Vol 65 (10) ◽  
pp. A1781
Author(s):  
Lydia R. Engwenyu ◽  
Fabiana Rollini ◽  
Francesco Franchi ◽  
Jung Rae Cho ◽  
Mona Bhatti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
P2y12 Receptor ◽  
Receptor Signaling ◽  
Patients With Diabetes

scholarly journals Prescribing Trend of Antirheumatic Drugs in Taiwan and Risk of Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Nationwide Cohort Study

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Chien-Ying Lee ◽  
Chih-Jaan Tai ◽  
Ya-Fang Tsai ◽  
Yu-Hsiang Kuan ◽  
Chiu-Hsiang Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Control Group ◽  
Research Database ◽  
Antirheumatic Drugs ◽  
Prescribing Trend

We aimed to investigate the prescribing trend of antirheumatic drugs and assess the risk of cardiovascular disease in patients with rheumatoid arthritis in Taiwan. This study was a retrospective cohort study, conducted based on the Taiwan National Health Insurance Research Database. The study subjects were 15,366 new rheumatoid arthritis patients from 2003 to 2010. To avoid selection bias, we applied propensity score matching to obtain general patients, as the control group. Cox proportional hazard model was used to evaluate the risk of cardiovascular disease in rheumatoid arthritis patients. The most common prescriptions of rheumatoid arthritis were nonsteroidal anti-inflammatory drugs. After controlling for related variables, rheumatoid arthritis patients had a higher risk of cardiovascular disease than general patients (adjusted hazard ratio [aHR] = 1.31; 95% confidence interval [CI]: 1.23-1.39). Age was the most significantly associated risk factor with the cardiovascular disease. Other observed risk factors for cardiovascular disease included hypertension (aHR = 1.57, 95% CI: 1.48-1.65), diabetes mellitus (aHR = 1.47, 95% CI: 1.38-1.57), and chronic kidney disease (aHR = 1.48, 95% CI: 1.31-1.66). Patients with rheumatoid arthritis indeed had a higher risk of incident cardiovascular diseases. Besides, age, hypertension, diabetes mellitus, and chronic kidney disease were also associated with a higher risk of cardiovascular disease.

scholarly journals Treatment Failure of Active Vitamin D Therapy in Chronic Kidney Disease: Predictive Factors

2015 ◽  
Vol 42 (3) ◽  
pp. 228-236 ◽  
Author(s):  
Mario Cozzolino ◽  
Adrian Covic ◽  
Blanca Martinez-Placencia ◽  
Konstantinos Xynos
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Treatment Failure ◽  
Serum Levels ◽  
Clinical Effects ◽  
Active Vitamin ◽  
Ipth Level ◽  
Active Vitamin D ◽  
Vitamin D Levels

Background: In patients with chronic kidney disease (CKD), impaired renal function leads to decreased vitamin D levels, which causes an increase in parathyroid hormone (PTH) production and contributes to the development of secondary hyperparathyroidism (SHPT). This may result in adverse clinical effects such as bone disorders, vascular calcification, cardiovascular disease, and increased mortality. Current treatment practices and associated outcomes with active vitamin D treatment in patients with CKD were reviewed with the objective to assess parameters (such as PTH and serum calcium levels) that may be used to define the failure of vitamin D treatment. Summary: Reports based on observational data have noted improved outcomes with active vitamin D treatment (calcitriol, paricalcitol, alfacalcidol, or doxercalciferol) in patients with CKD. Criteria for the identification of active vitamin D treatment failure are unclear from current guidelines, although up to 50% of patients may experience treatment failure eventually because of development of hypercalcemia or resistant SHPT, characterized by an elevated intact PTH (iPTH) level despite treatment. We propose a definition of vitamin D treatment failure as iPTH >600 pg/ml after 6 months of intravenous active vitamin D treatment and corrected total calcium serum levels >10.2 mg/dl, and review factors that may predict the response to vitamin D treatment. Key Message: Active vitamin D treatment failure is an important challenge in clinical practice. The aim of the proposed definition is to suggest a possible framework for hypothesis generation and to encourage further research into this common problem.

Progression of chronic kidney disease in a multi-ethnic community cohort of patients with diabetes mellitus

2013 ◽  
Vol 30 (8) ◽  
pp. 956-963 ◽  
Author(s):  
G. Dreyer ◽  
S. Hull ◽  
R. Mathur ◽  
A. Chesser ◽  
M. M. Yaqoob
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Ethnic Community ◽  
Patients With Diabetes
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