scholarly journals Osteonecrosis of the maxilaries associated with use of biphosphonate

2019 ◽  
pp. 18-24 ◽  
Author(s):  
Jamille Lacerda
Keyword(s):  
Bone Metastasis ◽  
Impact Factor ◽  
Key Words ◽  
Pain Control ◽  
Treatment Of Osteoporosis ◽  
High Affinity ◽  
Osteonecrosis Of The Jaws ◽  
Key Words Osteonecrosis ◽  
Bone Metastasis Multiple ◽  
Multiple Myelomas

Introduction: Bisphosphonates (BF) are inhibitors of reabsorption bone and are indicated for the treatment of Osteoporosis, Bone Metastasis, Multiple Myelomas and Paget's Disease. They are pyrophosphate analogs, which have high affinity for bone tissue inhibiting the action of osteoclasts. Although it has benefits for patients with of such diseases by assisting, for example, in the pain control prolonged use may lead to osteonecrosis of the jaws. Objectives: This article aims to review themedical literature on the use of bisphosbonates and dental surgeries. Materials and Methods: The indexed articles google academico and PubMed were scanned and the articles with the highest impact factor were selected. Results: We found 350 articles and selected 20 with the highest impact factor. Conclusion: Bisphosphonates are substances that can cause oteonecrosis in patients undergoing invasive dental treatments. KEY WORDS: Osteonecrosis, bisphosphonate, necrosis of the jaws

scholarly journals Management of Metastatic Bone Disease of the Extremities: A Systemic Review

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Mostafa ◽  
S I Azmy ◽  
M A Ahmad
Keyword(s):  
Survival Rate ◽  
Bone Metastasis ◽  
Surgical Management ◽  
Bone Disease ◽  
Pain Control ◽  
Metastatic Bone Disease ◽  
Systemic Review ◽  
Functional Improvement ◽  
Metastatic Tumors

Abstract Metastatic tumors are the commonest Tumors of the bone. Wide variety of surgical modalities are available for management of bone metastasis. This review describes functional improvement, pain control, and survival after surgical management of the bone metastasis. Surgical management is found to lead to better pain control and functional improvement, with comparable results of survival rate with other reviews like ours.

scholarly journals Prevention of bisphosphonate osteonecrosis in dental patient with osteoporosis

2020 ◽  
Vol 4 (34) ◽  
pp. 5-6
Author(s):  
D. V. Stomatov ◽  
Yu. V. Efimov ◽  
A. V. Stomatov ◽  
E. Yu. Efimova ◽  
A. A. Nesterov
Keyword(s):  
Scientific Literature ◽  
First Line ◽  
Treatment Of Osteoporosis ◽  
Osteonecrosis Of The Jaws ◽  
Dental Patient ◽  
Triggering Mechanisms ◽  
Effective Group ◽  
Bisphosphonate Osteonecrosis ◽  
Number Of Authors

The analysis of scientific literature on the use of bisphosphonates in the treatment of osteoporosis. This effective group of drugs was included in the first line of appointments by specialists dealing with the problem of osteoporosis. At the same time, a number of authors associate the appearance of medicinal osteonecrosis of the jaws, called BONJ (bisphosphonate osteonecrosis of the jaws), in patients with the administration of bisphosphonates. One of the triggering mechanisms of the emergence of BONJ are surgical dental interventions performed in patients receiving bisphosphonates. Today, patients may not understand the seriousness of taking these drugs and often do not warn the dentist before manipulation, as well as not all dentists attach importance to the danger of drugs from osteoporosis. In this paper, based on the analysis of scientific literature, the attention of dentists to the problem of possible complications in the treatment of patients with osteoporosis, taking bisphosphonates. A questionnaire included in the questionnaire of a dental patient, taking into account the name of the drug and the duration of its administration, is proposed.

CO2 syndrome in Chlorella

1991 ◽  
Vol 69 (5) ◽  
pp. 1003-1007 ◽  
Author(s):  
Mikio Tsuzuki ◽  
Shigetoh Miyachi
Keyword(s):  
Fatty Acids ◽  
Carbonic Anhydrase ◽  
Key Words ◽  
Inorganic Carbon ◽  
The Other ◽  
Fatty Acids Composition ◽  
High Affinity ◽  
Main Factors ◽  
Inorganic Carbon Transport ◽  
Carbon Transport

Effects of CO2 concentration on microalgae, especially on Chlorella, are discussed from the aspect of the high affinity of microalgae for inorganic carbon (Ci) in photosynthesis. Accumulation of Ci and carbonic anhydrase are the two main factors underlying the high affinity for Ci. The other factors such as development of carboxysomes and pyrenoids under low CO2 conditions may also be important. Contribution of each factor to the high affinity for Ci in photosynthesis seems to differ from species to species. Key words: Chlorella, inorganic carbon transport, carbonic anhydrase, fatty acids composition, CO2.

Oncology outpatients with pain from bone metastasis require more than around-the-clock dosing of analgesics to achieve adequate pain control

2002 ◽  
Vol 3 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Christine Miaskowski ◽  
Kayee Alice Mack ◽  
Marylin Dodd ◽  
Claudia West ◽  
Steven M. Paul ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Pain Control

scholarly journals Ultrasound-guided biopsy of osteolytic metastasis – could be less than three cores enough?

2018 ◽  
Vol 1 (1) ◽  
pp. 50
Author(s):  
Romeo Ioan Chira ◽  
Alexandra Chira ◽  
Adriana Calauz ◽  
Roberta Maria Manzat Saplacan ◽  
Georgiana Nagy ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Core Biopsy ◽  
Diagnostic Yield ◽  
Undifferentiated Carcinoma ◽  
Tissue Samples ◽  
Osteolytic Bone Metastasis ◽  
Osteolytic Metastasis ◽  
Diagnostic Role ◽  
Multiple Myelomas ◽  
Tissue Specimens

Aims: The purpose of this study was to analyze the diagnostic yield and accuracy of the ultrasound (US) guided core biopsy in a population of patients with osteolytic metastasis. Materials and methods: We performed a retrospective analysis of 16 consecutive cases of US-guided core biopsies of osteolytic lesions performed in our Ultrasound Unit, from January 2006 to May 2017. We used 18G or 16G Tru-cut needles coupled with automated biopsy guns. We procured a maximum number of two tissue specimens per patient.Results: We obtained a diagnostic yield and accuracy of 93.75% (15 of 16 patients) for US-guided core biopsy of osteolytic metastasis. Most of our cases were metastasis of adenocarcinomas (8 patients), squamous cell carcinomas (3 patients) followed by multiple myelomas (2 patients). Other pathologic lesions recorded were undifferentiated carcinoma (1 patient) and mesenchimal undifferentiated tumor (1 patient). The pathologic result was inconclusive in one patient.Conclusions: Our study supports the important diagnostic role of US-guided core biopsy for osteolytic bone metastasis. Two US-guided passages may be sufficient to procure a diagnostic tissue samples from osteolytic bone metastasis, if theirlength is at least 10 mm. 

Gamma knife surgery for cancer pain—pituitary gland—stalk ablation: a multicenter prospective protocol since 2002

2002 ◽  
Vol 97 ◽  
pp. 433-437 ◽  
Author(s):  
Motohiro Hayashi ◽  
Takaomi Taira ◽  
Mikhail Chernov ◽  
Seiji Fukuoka ◽  
Roman Liscak ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Cancer Pain ◽  
Pituitary Gland ◽  
Gamma Knife ◽  
Pain Control ◽  
Gamma Knife Radiosurgery ◽  
Intractable Pain ◽  
Content Type ◽  
Intractable Cancer Pain ◽  
Fine Print

Object. The authors have treated intractable pain, particularly cancer pain related to bone metastasis, with various protocols. Cancer pain has been treated by gamma knife radiosurgery (GKS), targeted to the pituitary gland—stalk, as an alternative new pain control method. The purpose of this study was to investigate a prospective multicenter protocol to prove the efficacy and the safety of this treatment. Methods. Indications for patient inclusion in this treatment protocol were: 1) pain related to bone metastasis; 2) no other effective pain treatment options; 3) general condition rated as greater than 40 on the Karnofsky Performance Scale; 4) morphine effective for pain control; and 5) no previous treatment with radiation (GKS or conventional radiotherapy) for brain metastasis. The authors at one institution have treated two patients, who suffered from severe cancer pain related to bone metastasis, by using GKS. The target was the pituitary gland. The maximum dose was 160 Gy with one isocenter of an 8-mm collimator, keeping the radiation dose to the optic nerve less than 8 Gy. At another institution two patients were treated in the same way; an additional five patients were treated similarly with targeting of the pituitary gland with two isocenters of 4-mm collimator. In all nine cases, pain resolved without significant complication. Pain relief was observed within several days, and this effect was prolonged until the day that they died. At a follow up of 1 to 24 months, no recurrences and no hormonal dysfunction were observed. Conclusions. Despite insufficient experience, the efficacy and the safety of GKS for intractable pain were demonstrated in nine patients. This treatment has the potential to ameliorate cancer-related pain, and GKS will play a more important role in the treatment of intractable pain. More experience and additional refined study protocols are needed to evaluate which parameters are important, to determine what treatment strategy is the best, and to clarify the safest option for patients with intractable cancer pain.

scholarly journals Pain control by ionizing radiation of bone metastasis

2004 ◽  
Vol 48 (5-6) ◽  
pp. 599-606 ◽  
Author(s):  
Luc A.M.-L. Vakaet ◽  
Tom Boterberg
Keyword(s):  
Bone Metastasis ◽  
Ionizing Radiation ◽  
Pain Control

scholarly journals Assessment of renal toxicity and osteonecrosis of the jaws in patients receiving zoledronic acid for bone metastasis

2007 ◽  
Vol 18 (3) ◽  
pp. 556-560 ◽  
Author(s):  
D. Aguiar Bujanda ◽  
U. Bohn Sarmiento ◽  
M.Á. Cabrera Suárez ◽  
J. Aguiar Morales
Keyword(s):  
Zoledronic Acid ◽  
Bone Metastasis ◽  
Renal Toxicity ◽  
Osteonecrosis Of The Jaws
Sign in / Sign up

Export Citation Format

Share Document