Ultrasonic and biochemical characteristics of the hepatobiliary system in congenital cytomegalovirus infection in dead full-term

The aim of the study was to study the morphological structure of the liver in newborns with congenital cytomegalovirus infection. The material for the study was the liver of 36 full-term newborns who died on the 2nd-5th day of life from birth trauma, intranatal and postnatal hypoxia. The main study group included 16 full-term newborns with congenital cytomegalovirus infection. The comparison group included 20 newborns from mothers without any viral infections, as well as moderate, severe somatic diseases and obstetric pathology during pregnancy, and these babies died at the 2nd-5th day of life from birth trauma, intrapartum and postnatal hypoxia. The main cause of death of children of early neonatal age was intrauterine infection which was clinically manifested by moderate or severe cerebral ischemia with hypertension-hydrocephalic syndrome, pseudocysts of the vascular plexus, subependymal and subarachnoid hemorrhages, monocytosis, vesiculosis, pneumonia, hepatitis and meningoencephalitis and antenatal hypoxia caused by the development of subcompensated placental insufficiency. When describing the liver, the attention was drawn to the following macroscopic and pathohistological changes in the organ: 1) the condition of the capsule of the organ; 2) the change of the general plan of a structure; 3) the reaction of the bloodstream of the liver: 4) the condition of the portal tracts; 5) the state of the lumen of the bile ducts and its epithelium. The material was fixed in 10% neutral formalin, dehydrated in alcohols and poured into paraffin. For observational microscopy, histological sections 5-7 μm thick were stained with Böhmer hematoxylin and eosin. Morphological examination of the liver in the newborns of the main group showed an increase in the frequency of detection of subcapsular hematomas, pronounced congestion of sinusoids, foci of lymphohistiocytic infiltration of the connective tissue of the portal tracts, small-focal proliferation of Kupffer cells, alterative and proliferative changes in the epithelium of the bile ducts, as well as cells with viral metamorphosis. The revealed structural changes in the morphological structure of the liver in full-term newborns indicate the development of pronounced dyscirculatory, alterative and inflammatory changes in the liver of cytomegalovirus genesis.

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Functional state of the liver in congenital cytomegalovirus infection in dead full -term newborns

Bulletin physiology and pathology of respiration ◽

10.36604/1998-5029-2020-75-92-96 ◽

2020 ◽

pp. 92-96

Author(s):

I. A. Andrievskaya ◽

I. N. Gorikov ◽

L. M. Somova ◽

N. A. Ishutina ◽

A. N. Odireev ◽

...

Keyword(s):

Functional State ◽

Cytomegalovirus Infection ◽

Full Term ◽

Congenital Cytomegalovirus Infection ◽

Congenital Cytomegalovirus ◽

Term Newborns

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Clinical features of the TORCH syndrome in newborns with congenital cytomegalovirus infection depending on birth body weight

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2021-66-1-66-72 ◽

2021 ◽

Vol 66 (1) ◽

pp. 66-72

Author(s):

O. K. Kirilochev ◽

D. F. Sergienko ◽

A. I. Kibirova

Keyword(s):

Body Weight ◽

Hemolytic Anemia ◽

Clinical Features ◽

Congenital Heart Defects ◽

Cytomegalovirus Infection ◽

Congenital Heart ◽

Heart Defects ◽

Full Term ◽

Congenital Cytomegalovirus Infection ◽

Congenital Cytomegalovirus

Objective: to study the clinical features of TORCH syndrome in newborns with congenital cytomegalovirus infection depending on body weight at birthCharacteristics of children and research methods. The study included 70 patients (43 premature, 27 full-term) with with congenital acute cytomegalovirus infection, manifested form. Patient characteristics: Group 1: 21 premature children with extremely and very low body weight at birth; Group 2: 22 premature children with very low body weight; Group 3: 27 full-term children with body weight more than 2,500 g. The congenital cytomegalovirus infection was diagnosed on the presence of TORCH syndrome and etiological verification in the first 3 weeks of life.Results. The authors found that children with extremely and very low body weight significantly more often (p<0.05) had hydrocephalus and interstitial pneumonia than children with low body weight. The full-term patients weighing more than 2,500 g suffered from hemolytic anemia, brain calcifications and congenital heart defects (p<0.05) statistically significantly more often than preterm patients. Reduced duration of pregnancy in preterm labor contributes to the rare occurrence of hemolytic anemia and calcifications in the brain of premature babies. Periventricular localization of calcifications is characteristic of full-term infants. It is necessary to exclude congenital cytomegalovirus infection in newborns with congenital heart defects and other clinical manifestations of TORCH syndrome.Conclusion. The results of the study can be used to diagnose cytomegalovirus infection in children, depending on the birth weight.

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MORPHOLOGICAL STRUCTURE OF ADRENAL CORTEX IN FULL-TERM NEWBORNS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION

Bulletin physiology and pathology of respiration ◽

10.12737/article_5b984f32012565.06234117 ◽

2018 ◽

Vol 1 (69) ◽

pp. 70-73

Author(s):

Игорь Гориков ◽

Igor Gorikov ◽

Лариса Сомова ◽

Larisa Somova ◽

Ирина Андриевская ◽

...

Keyword(s):

Adrenal Cortex ◽

Cytomegalovirus Infection ◽

Comparison Group ◽

Main Group ◽

Full Term ◽

Congenital Cytomegalovirus Infection ◽

Congenital Cytomegalovirus ◽

General Plan ◽

Suprarenal Glands ◽

Term Newborns

The aim was to study the structure of the adrenal cortex in 36 dead full-term newborns. The main group consisted of 16 newborns with congenital cytomegalovirus infection, clinically manifested by moderate and severe cerebral ischemia, predominance of hypertensive-hydrocephalic syndrome, pseudocysts of the vascular plexus, sub-perpendicular and subarachnoid hemorrhages, monocytosis, vesiculosis, pneumonia, hepatitis and meningoencephalitis. The comparison group consisted of 20 dead newborns from mothers who did not have infectious diseases during pregnancy, as well as moderate and severe somatic and obstetric pathology. Birth trauma, intranatal and postnatal hypoxia were the main cause of their death. The evaluation of the pathomorphological picture of the adrenal cortex included a description of the general plan of the structure, the severity of alterative changes in glandulocytes, the number of adenomatous-like structures and their morphological forms, the reaction of loose fibrous connective tissue. It was found out that in suprarenal glands in children of the main group unlike the comparison group there was often detected a breach of the strands of granulocytes, there were found pronounced alterative changes in the cells; there were revealed large adenomatous-like structures in the lumen of which eosinophilic mass was often found and there was observed strongly-pronounced plethora of vessels. Only in the main group there were determined areas of thinning of the cortical substance of the glands, several adenomatous-like formations and anatomical forms containing in their lumen red blood cells and erythroblasts, as well as large hemorrhages. These structural changes indicated inhibition of adrenal cortex formation and prolonged antenatal stimulation of steroidogenesis under the influence of congenital cytomegalovirus infection leading to a decrease in glucocorticoid function of the suprarenal glands in children after birth.

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