scholarly journals MORPHOLOGIC CONDITION OF THE LIVER IN NEWBORNS WITH INBORN CYTOMEGALOVIRUS INFECTION

2018 ◽  
Vol 1 (67) ◽  
pp. 60-63
Author(s):  
Наталия Ишутина ◽  
Nataliya Ishutina ◽  
Игорь Гориков ◽  
Igor Gorikov ◽  
Лариса Сомова ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Bile Ducts ◽  
Morphological Structure ◽  
Birth Trauma ◽  
Full Term ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
General Plan ◽  
Term Newborns ◽  
Portal Tracts

The aim of the study was to study the morphological structure of the liver in newborns with congenital cytomegalovirus infection. The material for the study was the liver of 36 full-term newborns who died on the 2nd-5th day of life from birth trauma, intranatal and postnatal hypoxia. The main study group included 16 full-term newborns with congenital cytomegalovirus infection. The comparison group included 20 newborns from mothers without any viral infections, as well as moderate, severe somatic diseases and obstetric pathology during pregnancy, and these babies died at the 2nd-5th day of life from birth trauma, intrapartum and postnatal hypoxia. The main cause of death of children of early neonatal age was intrauterine infection which was clinically manifested by moderate or severe cerebral ischemia with hypertension-hydrocephalic syndrome, pseudocysts of the vascular plexus, subependymal and subarachnoid hemorrhages, monocytosis, vesiculosis, pneumonia, hepatitis and meningoencephalitis and antenatal hypoxia caused by the development of subcompensated placental insufficiency. When describing the liver, the attention was drawn to the following macroscopic and pathohistological changes in the organ: 1) the condition of the capsule of the organ; 2) the change of the general plan of a structure; 3) the reaction of the bloodstream of the liver: 4) the condition of the portal tracts; 5) the state of the lumen of the bile ducts and its epithelium. The material was fixed in 10% neutral formalin, dehydrated in alcohols and poured into paraffin. For observational microscopy, histological sections 5-7 μm thick were stained with Böhmer hematoxylin and eosin. Morphological examination of the liver in the newborns of the main group showed an increase in the frequency of detection of subcapsular hematomas, pronounced congestion of sinusoids, foci of lymphohistiocytic infiltration of the connective tissue of the portal tracts, small-focal proliferation of Kupffer cells, alterative and proliferative changes in the epithelium of the bile ducts, as well as cells with viral metamorphosis. The revealed structural changes in the morphological structure of the liver in full-term newborns indicate the development of pronounced dyscirculatory, alterative and inflammatory changes in the liver of cytomegalovirus genesis.

scholarly journals MORPHOLOGICAL STRUCTURE OF ADRENAL CORTEX IN FULL-TERM NEWBORNS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION

2018 ◽  
Vol 1 (69) ◽  
pp. 70-73
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Лариса Сомова ◽  
Larisa Somova ◽  
Ирина Андриевская ◽  
...  
Keyword(s):  
Adrenal Cortex ◽  
Cytomegalovirus Infection ◽  
Comparison Group ◽  
Main Group ◽  
Full Term ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
General Plan ◽  
Suprarenal Glands ◽  
Term Newborns

The aim was to study the structure of the adrenal cortex in 36 dead full-term newborns. The main group consisted of 16 newborns with congenital cytomegalovirus infection, clinically manifested by moderate and severe cerebral ischemia, predominance of hypertensive-hydrocephalic syndrome, pseudocysts of the vascular plexus, sub-perpendicular and subarachnoid hemorrhages, monocytosis, vesiculosis, pneumonia, hepatitis and meningoencephalitis. The comparison group consisted of 20 dead newborns from mothers who did not have infectious diseases during pregnancy, as well as moderate and severe somatic and obstetric pathology. Birth trauma, intranatal and postnatal hypoxia were the main cause of their death. The evaluation of the pathomorphological picture of the adrenal cortex included a description of the general plan of the structure, the severity of alterative changes in glandulocytes, the number of adenomatous-like structures and their morphological forms, the reaction of loose fibrous connective tissue. It was found out that in suprarenal glands in children of the main group unlike the comparison group there was often detected a breach of the strands of granulocytes, there were found pronounced alterative changes in the cells; there were revealed large adenomatous-like structures in the lumen of which eosinophilic mass was often found and there was observed strongly-pronounced plethora of vessels. Only in the main group there were determined areas of thinning of the cortical substance of the glands, several adenomatous-like formations and anatomical forms containing in their lumen red blood cells and erythroblasts, as well as large hemorrhages. These structural changes indicated inhibition of adrenal cortex formation and prolonged antenatal stimulation of steroidogenesis under the influence of congenital cytomegalovirus infection leading to a decrease in glucocorticoid function of the suprarenal glands in children after birth.

scholarly journals Changes in lipid-synthesizing function of the liver in congenital cytomegalovirus infection in death newborns

2021 ◽  
pp. 79-83
Author(s):  
I. N. Gorikov ◽  
L. G. Nakhamchen ◽  
A. N. Оdireev ◽  
E. I. Karapetyan ◽  
T. V. Smirnova ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Indirect Effect ◽  
Cytomegalovirus Infection ◽  
Morphological Structure ◽  
High Density ◽  
High Density Lipoproteins ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Triglyceride Concentration ◽  
Term Newborns

Aim. To assess the change in the lipid-synthesizing function of the liver in congenital cytomegalovirus infection (CMVI) in dead newborns.Materials and methods. The study of the lipid spectrum of umbilical cord blood in the first minutes of life was carried out in 59 full-term newborns with antenatal ontogenesis, unburdened and burdened with congenital CMVI. The first group consisted of 25 newborns of early neonatal age (control group) from mothers without moderate and severe obstetric and somatic pathology, as well as respiratory viral diseases and sexually transmitted infections. The second group included 18 children of the same age (comparison group), whose mothers suffered exacerbation of CMVI in the second trimester of pregnancy, which did not lead to antenatal viral aggression. The third group was represented by 16 newborns with congenital CMVI. The life expectancy of children was 2-5 days. In the first group, the main cause of death of children was prolonged ante- and intranatal hypoxia, atelectasis and hyaline membranes of the lungs, in the second group – prolonged antenatal hypoxia, intranatal hypoxia and atelectatic, hyaline and edematous-hemorrhagic pneumopathies, and in the third group – congenital CMVI, which manifested itself as cerebral ischemia of moderate and severe degree, meningoencephalitis, ventriculomegaly, pseudocysts of the vascular plexus and subarachnoid hemorrhages, monocytosis, vesiculopustulosis, hepatitis and pneumonia. In the blood serum from the umbilical vein during biochemical analysis, the concentration (mmol/L) of total cholesterol, high-density lipoproteins, low-density lipoproteins and triglycerides was estimated.Results. In newborns of the second group in the blood serum from the umbilical cord vein, the concentration of total cholesterol was 1.90±0.04 mmol/L, high-density lipoproteins – 1.49±0.06 mmol/L, low-density lipoproteins - 0.26±0,02 mmol/L and triglycerides – 0.49±0.03 mmol/L (in the first group, respectively, 1.93±0.06 mmol/L, p>0.05; 1.37±0.06 mmol/L, p>0.05; 0.43±0.02 mmol/L, p<0.001; 0.45±0.02 mmol/L, p>0.05). In the third group, compared with the second one, there was a decrease in the level of total cholesterol to 1.79±0.04 mmol/L (p<0.05) and high-density lipoproteins – to 1.28±0.06 (p><0.05) against the background of an increase in triglyceride concentration up to 0.59±0.03 mmol/L (p><0.05). Conclusion. The above changes in the lipid-synthesizing function of the liver indicate a direct and indirect effect of congenital CMVI on the morphological structure of hepatocytes and the activity of enzyme systems. Key words: full-term newborns, congenital cytomegalovirus infection, total cholesterol, high-density lipoproteins, lowdensity lipoproteins, triglyceride>˂ 0.05) and high-density lipoproteins – to 1.28±0.06 (p<0.05) against the background of an increase in triglyceride concentration up to 0.59±0.03 mmol/L (p><0.05). Conclusion. The above changes in the lipid-synthesizing function of the liver indicate a direct and indirect effect of congenital CMVI on the morphological structure of hepatocytes and the activity of enzyme systems. Key words: full-term newborns, congenital cytomegalovirus infection, total cholesterol, high-density lipoproteins, lowdensity lipoproteins, triglycerides>˂ 0.05) against the background of an increase in triglyceride concentration up to 0.59±0.03 mmol/L (p˂ 0.05).Conclusion. The above changes in the lipid-synthesizing function of the liver indicate a direct and indirect effect of congenital CMVI on the morphological structure of hepatocytes and the activity of enzyme systems. 

Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rate

2001 ◽  
Vol 20 (2) ◽  
pp. 188-192 ◽  
Author(s):  
APARECIDA YULIE YAMAMOTO ◽  
MARISA M??RCIA MUSSI-PINHATA ◽  
PATRICIA CRISTINA GOMES PINTO ◽  
LUIZ TADEU MORAES FIGUEIREDO ◽  
SALIM MOYS??S JORGE
Keyword(s):  
Cytomegalovirus Infection ◽  
Newborn Infants ◽  
Full Term ◽  
Seroprevalence Rate ◽  
High Seroprevalence ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Term Newborn

scholarly journals ECHOSTRUCTURE AND PATHOMORPHOLOGICAL CHARACTERISTICS OF THE CEREBROSPINAL FLUID SPACE OF THE BRAIN IN NEWBORNS WITH CONGENITAL CYTOMEGALOVIRUS INFECTION

2019 ◽  
Vol 1 (71) ◽  
pp. 94-99
Author(s):  
Игорь Гориков ◽  
Igor Gorikov ◽  
Лариса Сомова ◽  
Larisa Somova ◽  
Ирина Андриевская ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Morphological Study ◽  
Lymphocytic Infiltration ◽  
Congenital Cytomegalovirus Infection ◽  
Intrauterine Development ◽  
Vascular Plexus ◽  
Congenital Cytomegalovirus ◽  
Perivascular Edema ◽  
Term Newborns ◽  
The Brain

In 36 full-term newborns who died at an early neonatal age under various conditions of intrauterine development, ultrasound examination and morphological study of the brain liquor space was conducted at the 1st-2nd days of life. The first group included 20 newborns aged 38-40 weeks, whose cause of death on the 4th -5th day of life was intranatal and postnatal hypoxia. The second group included 16 dead children of the same age with congenital cytomegalovirus infection. It was found out that immaturity (n=7, p<0.05), pseudocysts of the vascular plexus of the lateral ventricles (n=9, p<0.5), as well as intraventricular hemorrhages of I degree (n=8, p<0.05) were more often diagnosed in the second group compared with the first one in neurosonographic study. Only in the second group there was a pronounced ventriculomegaly. A morphological study in the brain often detected a pronounced pericellular and perivascular edema, alterative changes of neurons, vasculitis (n=7), subependyma (n=3), choriocephalitis (n=3) and encephalitis (n=1) with small calcifications, ependymocyte desquamation and lymphocytic infiltration, with a pronounced hyperemia and hemorrhages. In all cases, specific cells of the "owl's eye" were not detected. The detected ultrasound and pathomorphological changes in the liquor space in intrauterine cytomegalovirus infection indicate the possibility of direct cytodestructive effect of the pathogen in the absence of markers of viral metamorphosis, as well as the indirect effect of antenatal hypoxia, endotoxemia and cytokineemia on the brain in newborns

scholarly journals Clinical features of the TORCH syndrome in newborns with congenital cytomegalovirus infection depending on birth body weight

2021 ◽  
Vol 66 (1) ◽  
pp. 66-72
Author(s):  
O. K. Kirilochev ◽  
D. F. Sergienko ◽  
A. I. Kibirova
Keyword(s):  
Body Weight ◽  
Hemolytic Anemia ◽  
Clinical Features ◽  
Congenital Heart Defects ◽  
Cytomegalovirus Infection ◽  
Congenital Heart ◽  
Heart Defects ◽  
Full Term ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

Objective: to study the clinical features of TORCH syndrome in newborns with congenital cytomegalovirus infection depending on body weight at birthCharacteristics of children and research methods. The study included 70 patients (43 premature, 27 full-term) with with congenital acute cytomegalovirus infection, manifested form. Patient characteristics: Group 1: 21 premature children with extremely and very low body weight at birth; Group 2: 22 premature children with very low body weight; Group 3: 27 full-term children with body weight more than 2,500 g. The congenital cytomegalovirus infection was diagnosed on the presence of TORCH syndrome and etiological verification in the first 3 weeks of life.Results. The authors found that children with extremely and very low body weight significantly more often (p<0.05) had hydrocephalus and interstitial pneumonia than children with low body weight. The full-term patients weighing more than 2,500 g suffered from hemolytic anemia, brain calcifications and congenital heart defects (p<0.05) statistically significantly more often than preterm patients. Reduced duration of pregnancy in preterm labor contributes to the rare occurrence of hemolytic anemia and calcifications in the brain of premature babies. Periventricular localization of calcifications is characteristic of full-term infants. It is necessary to exclude congenital cytomegalovirus infection in newborns with congenital heart defects and other clinical manifestations of TORCH syndrome.Conclusion. The results of the study can be used to diagnose cytomegalovirus infection in children, depending on the birth weight.

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