Utilization of Human Skin Equivalent in Research of Scabies Pathogenesis

Scabies is a tropical disease that requires large-scale control. Research on the pathogenesis of scabies in Indonesia is still rare. Meanwhile, in tropical countries, studies related to the course of scabies have been done quite a lot, one of which is by using a human skin model. The purpose of writing this article is to discuss the use of human skin modeling technology in researching the course of scabies. Research using HSE demonstrated modulation of cytokine secretion, expression of cell adhesion molecules, and gene expression in response to the scabies mite extract molecule.

Download Full-text

Desmosomal distribution in the epidermis of a non-contracting human skin equivalent

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100124884 ◽

1992 ◽

Vol 50 (1) ◽

pp. 896-897

Author(s):

L.X. Oakford ◽

S.D. Dimitrijevich ◽

R. Gracy

Keyword(s):

Human Skin ◽

Basal Layer ◽

Skin Equivalent ◽

Tissue Component ◽

Intact Skin ◽

Similar Sequence ◽

Sequence Of Events ◽

Suprabasal Keratinocytes ◽

Human Skin Equivalent

In intact skin the epidermal layer is a dynamic tissue component which is maintained by a basal layer of mitotically active cells. The protective upper epidermis, the stratum corneum, is generated by differentiation of the suprabasal keratinocytes which eventually desquamate as anuclear comeocytes. A similar sequence of events is observed in vitro in the non-contracting human skin equivalent (HSE) which was developed in this lab (1). As a part of the definition process for this model of living skin we are examining its ultrastructural features. Since desmosomes are important in maintaining cell-cell interactions in stratified epithelia their distribution in HSE was examined.

Download Full-text

Transformative Encounters and Uncanny Intimacies: Biotechnology and Contemporary Art – A Practitioner's Approach and Perspective

Somatechnics ◽

10.3366/soma.2012.0061 ◽

2012 ◽

Vol 2 (2) ◽

pp. 263-283 ◽

Cited By ~ 1

Author(s):

Svenja J. Kratz

Keyword(s):

Tissue Culture ◽

Human Skin ◽

Contemporary Art ◽

Skin Equivalent ◽

Biomedical Innovation ◽

Equivalent Models ◽

Science Projects ◽

Insight Into ◽

Human Skin Equivalent

Abstract: Presented from an ArtScience practitioner's perspective, this paper provides an overview of Svenja Kratz's experience working as an artist within the area of cell and tissue culture at QUT's Institute of Health and Biomedical Innovation (IHBI). Using The Absence of Alice, a multi-medium exhibition based on the experience of culturing cells, as a case study, the paper gives insight into the artist's approach to working across art and science and how ideas, processes, and languages from each discipline can intermesh and extend the possibilities of each system. The paper also provides an overview of her most recent artwork, The Human Skin Equivalent/Experience Project, which involves the creation of personal jewellery items incorporating human skin equivalent models grown from the artist's skin and participant cells. Referencing this project, and other contemporary bioart works, the value of ArtScience is discussed, focusing in particular on the way in which cross-art-science projects enable an alternative voice to enter into scientific dialogues and have the potential to yield outcomes valuable to both disciplines.

Download Full-text

Some Results on Stabilizability of Large-Scale Control Systems with Indetrminancy

1992 American Control Conference ◽

10.23919/acc.1992.4792764 ◽

1992 ◽

Author(s):

A.S.C Sinha

Keyword(s):

Control Systems ◽

Large Scale ◽

Scale Control

Download Full-text

Keratinocytes and Fibroblasts in a Human Skin Equivalent Model Enhance Melanocyte Survival and Melanin Synthesis After Ultraviolet Irradiation

Journal of Investigative Dermatology ◽

10.1111/1523-1747.ep12607034 ◽

1995 ◽

Vol 104 (5) ◽

pp. 859-867 ◽

Cited By ~ 74

Author(s):

Michael Archambault ◽

Mina Yaar ◽

Barbara A Gilchrest

Keyword(s):

Human Skin ◽

Ultraviolet Irradiation ◽

Skin Equivalent ◽

Equivalent Model ◽

Melanin Synthesis ◽

Human Skin Equivalent Model ◽

Human Skin Equivalent

Download Full-text

Disinfectant effectiveness against SARS-CoV-2 and influenza viruses present on human skin: model-based evaluation

Clinical Microbiology and Infection ◽

10.1016/j.cmi.2021.04.009 ◽

2021 ◽

Author(s):

Ryohei Hirose ◽

Risa Bandou ◽

Hiroshi Ikegaya ◽

Naoto Watanabe ◽

Takuma Yoshida ◽

...

Keyword(s):

Human Skin ◽

Influenza Viruses ◽

Skin Model ◽

Model Based

Download Full-text

Acoustoelectronic nanotweezers enable dynamic and large-scale control of nanomaterials

Nature Communications ◽

10.1038/s41467-021-24101-z ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Peiran Zhang ◽

Joseph Rufo ◽

Chuyi Chen ◽

Jianping Xia ◽

Zhenhua Tian ◽

...

Keyword(s):

Large Scale ◽

Condensed Matter ◽

Dynamic Control ◽

Massively Parallel ◽

Large Field ◽

Graphene Flakes ◽

Field Dynamic ◽

Scale Control ◽

Orientation Pattern ◽

Resolution Single

AbstractThe ability to precisely manipulate nano-objects on a large scale can enable the fabrication of materials and devices with tunable optical, electromagnetic, and mechanical properties. However, the dynamic, parallel manipulation of nanoscale colloids and materials remains a significant challenge. Here, we demonstrate acoustoelectronic nanotweezers, which combine the precision and robustness afforded by electronic tweezers with versatility and large-field dynamic control granted by acoustic tweezing techniques, to enable the massively parallel manipulation of sub-100 nm objects with excellent versatility and controllability. Using this approach, we demonstrated the complex patterning of various nanoparticles (e.g., DNAs, exosomes, ~3 nm graphene flakes, ~6 nm quantum dots, ~3.5 nm proteins, and ~1.4 nm dextran), fabricated macroscopic materials with nano-textures, and performed high-resolution, single nanoparticle manipulation. Various nanomanipulation functions, including transportation, concentration, orientation, pattern-overlaying, and sorting, have also been achieved using a simple device configuration. Altogether, acoustoelectronic nanotweezers overcome existing limitations in nano-manipulation and hold great potential for a variety of applications in the fields of electronics, optics, condensed matter physics, metamaterials, and biomedicine.

Download Full-text