scholarly journals Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells

2017 ◽  
Vol 25 (3) ◽  
pp. 331-340 ◽  
Author(s):  
Bingqian Ding ◽  
Bei Cui ◽  
Ming Gao ◽  
Zhenjiang Li ◽  
Chenyang Xu ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Antitumor Activity ◽  
In Vitro Cytotoxicity ◽  
Related Protein ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme ◽  
In Vivo Antitumor Activity

Cytotoxicity and Antitumor Activity of Platinum(II) Complexes of Aromatic and Cycloalkanecarboxylic Acid Hydrazides

1997 ◽  
Vol 52 (1-2) ◽  
pp. 49-54 ◽  
Author(s):  
Daniel N. Kushev ◽  
Nadejda C. Spassovska ◽  
Svetoslav I. Taxirov ◽  
Konstantin C. Grancharov
Keyword(s):  
Antitumor Activity ◽  
Acid Hydrazide ◽  
In Vitro Cytotoxicity ◽  
Macromolecular Synthesis ◽  
H Nmr ◽  
Antineoplastic Effect ◽  
In Vivo Antitumor Activity ◽  
Friend Leukemia

AbstractNew platinum(II) complexes of cyclohexanecarboxylic acid hydrazide (chcah) were synthesized and characterized by elemental analysis, IR. and 1H NMR spectra. Their inhibitory effects on cell growth and macromolecular synthesis of Friend leukemia cells in culture as well as the in vivo antitumor activity towards L1210 leukemia in mice were compared with those of complexes containing differently substituted aromatic acid hydrazides. Some of the complexes exhibited antineoplastic activity. No correlation between the in vitro cytotoxicity and the in vivo antitumor activity was found. However, there was a relationship between the in vitro macromolecular synthesis inhibition profile and the in vivo antineoplastic effect, similar to that of cisplatin. On the other hand, only agents containing one ammine ligand were active in vivo. The substitution of the aromatic ring by a cycloalkane residue increased significantly the antitumor effect, with [Pt(NH3)(chcah)Cl2] being the most active compound in this study.

scholarly journals Assessment of in vitro cytotoxicity and in vivo antitumor activity of Sphaeranthus amaranthoides burm.f

2015 ◽  
Vol 7 (2) ◽  
pp. 198 ◽  
Author(s):  
C Gayatri ◽  
CUma Maheswara Reddy ◽  
K Chitra ◽  
V Parthasarathy
Keyword(s):  
Antitumor Activity ◽  
In Vitro Cytotoxicity ◽  
In Vivo Antitumor Activity

GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models

2013 ◽  
Vol 56 (7) ◽  
pp. 2911-2935 ◽  
Author(s):  
Khondaker M. Rahman ◽  
Paul J. M. Jackson ◽  
Colin H. James ◽  
B. Piku Basu ◽  
John A. Hartley ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mouse Models ◽  
In Vitro Cytotoxicity ◽  
In Vivo Antitumor Activity

Maintenance of EGFR and EGFRvIII expressions in an in vivo and in vitro model of human glioblastoma multiforme

2011 ◽  
Vol 317 (11) ◽  
pp. 1513-1526 ◽  
Author(s):  
Marie-Thérése Stockhausen ◽  
Helle Broholm ◽  
Mette Villingshøj ◽  
Maria Kirchhoff ◽  
Tommy Gerdes ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
In Vitro Model ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme ◽  
Vitro Model

scholarly journals Evaluation of Ceiba pentandra (L.) Gaertner bark extracts for in vitro cytotoxicity on cancer cells and in vivo antitumor activity in solid and liquid tumor models

2016 ◽  
Vol 68 (5) ◽  
pp. 1909-1923 ◽  
Author(s):  
Ravishankar Kumar ◽  
Nitesh Kumar ◽  
Grandhi V. Ramalingayya ◽  
Manganahalli Manjunath Setty ◽  
Karkala Sreedhara Rangnath Pai
Keyword(s):  
Antitumor Activity ◽  
Cancer Cells ◽  
In Vitro Cytotoxicity ◽  
Tumor Models ◽  
Ceiba Pentandra ◽  
In Vivo Antitumor Activity

scholarly journals Lomeguatrib Increases the Radiosensitivity of MGMT Unmethylated Human Glioblastoma Multiforme Cell Lines

2021 ◽  
Vol 22 (13) ◽  
pp. 6781
Author(s):  
Anna Kirstein ◽  
Daniela Schilling ◽  
Stephanie E. Combs ◽  
Thomas E. Schmid
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Lines ◽  
Dna Methyltransferase ◽  
Treatment Options ◽  
Treatment Resistance ◽  
Cell Cycle Distribution ◽  
Human Glioblastoma ◽  
Human Glioblastoma Multiforme ◽  
Mgmt Protein

Background: Treatment resistance of glioblastoma multiforme to chemo- and radiotherapy remains a challenge yet to overcome. In particular, the O6-methylguanine-DNA-methyltransferase (MGMT) promoter unmethylated patients have only little benefit from chemotherapy treatment using temozolomide since MGMT counteracts its therapeutic efficacy. Therefore, new treatment options in radiotherapy need to be developed to inhibit MGMT and increase radiotherapy response. Methods: Lomeguatrib, a highly specific MGMT inhibitor, was used to inactivate MGMT protein in vitro. Radiosensitivity of established human glioblastoma multiforme cell lines in combination with lomeguatrib was investigated using the clonogenic survival assay. Inhibition of MGMT was analyzed using Western Blot. Cell cycle distribution and apoptosis were investigated to determine the effects of lomeguatrib alone as well as in combination with ionizing radiation. Results: Lomeguatrib significantly decreased MGMT protein and reduced radiation-induced G2/M arrest. A radiosensitizing effect of lomeguatrib was observed when administered at 1 µM and increased radioresistance at 20 µM. Conclusion: Low concentrations of lomeguatrib elicit radiosensitization, while high concentrations mediate a radioprotective effect.

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