scholarly journals Correlation Between Serum C-Reactive Protein (CRP) and Soluble Cd40 Ligand (sCD40L) with Disease Activity by Modified Rodnan Skin Score (mRSS) in Systemic Sclerosis Patients in Indonesia

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Widi Palupi Ayu Padmandani ◽  
Sumartini Dewi ◽  
Laniyati Hamijoyo
Keyword(s):  
Systemic Sclerosis ◽  
Disease Activity ◽  
Inflammatory Process ◽  
Pearson Correlation ◽  
Cd40 Ligand ◽  
C Reactive Protein ◽  
Soluble Cd40 Ligand ◽  
Skin Score ◽  
Reactive Protein ◽  
Modified Rodnan Skin Score

Introduction: Systemic Sclerosis (SSc) is a chronic autoimmune disease which presents immunological, endothelial dysfunction, skin and organs fibrosis. The inflammatory process is an important pathophysiology of systemic sclerosis. Disease activity assessment using clinical parameters of Modified Rodnan Skin Score (mRSS) changes and inflammatory laboratory parameters of C-Reactive Protein (CRP), Erytrocyte Sedimentation Rate (ESR) and soluble CD40 ligand. The European Scleroderma Study Group (EscSG) Activity Index uses CRP. CRP is higher sensitivity and specificity than ESR (80% and 91.2%). The study aims to evaluate the correlation between CRP and sCD40L with disease activity by mRSS.Methods: This research was a cross-sectional study, and data of mRSS and sCD40L were obtained from the study, "Blind Clinical Trials Extract Ciplukan Herbs on Clinical Improvement of Skin Disorders, Inflammatory Process, Immunology and Fibrosis in Scleroderma Patients”. CRP examination was done by using the rest samples of the study, conducted in December 2017. Data analysis with Rank-Spearman and Pearson Correlation..Result: There were fifty-eight subjects with mean age 38 ± 11 years old. Most of subjects were female (94.8%) and with a late disease duration > 2 years (74.1 %). Subjects consisted of 35 (60.3%) diffuse SSc and 23 (39.7 %) limited SSc. CRP was measured by Turbidimetric Immunoassay. Median (range) CRP serum was 2.89 (0.16–17.29) mg/L, while the median of sCD40L was 6457 (1018–17976) pg/mL, and the median of mRSS was 17 (4–36). There was no correlation between CRP and sCD40L with mRSS (r = -0.134, p = 0.167; and r = 0.023, p = 0.433).Conclusion: There was no correlation between CRP and sCD40L serum with mRSS in systemic sclerosis patients.

Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome

Metabolism ◽  
2010 ◽  
Vol 59 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Ilkay Tugba Unek ◽  
Firat Bayraktar ◽  
Dilek Solmaz ◽  
Hulya Ellidokuz ◽  
Faize Yuksel ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cd40 Ligand ◽  
C Reactive Protein ◽  
Soluble Cd40 Ligand ◽  
Reactive Protein

MS255 C-REACTIVE PROTEIN BUT NOT SOLUBLE CD40 LIGAND IS ASSOCIATED WITH THE SEVERITY OF ANGIOGRAPHICALLY VERIFIED CORONARY ARTERY DISEASE

2010 ◽  
Vol 11 (2) ◽  
pp. 161
Author(s):  
V. Spasojevic-Kalimanovska ◽  
S. Veljic ◽  
J. Kotur-Stevuljevic ◽  
N. Bogavac-Stanojevic ◽  
L. Memon ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cd40 Ligand ◽  
C Reactive Protein ◽  
Soluble Cd40 Ligand ◽  
Reactive Protein ◽  
Artery Disease

Osteopontin in antineutrophil cytoplasmic autoantibody-associated vasculitis: relation to disease activity, organ manifestation and immunosuppressive therapy

2010 ◽  
Vol 69 (6) ◽  
pp. 1169-1171 ◽  
Author(s):  
Johan Lorenzen ◽  
Svjetlana Lovric ◽  
Robert Krämer ◽  
Hermann Haller ◽  
Marion Haubitz
Keyword(s):  
Disease Activity ◽  
Immunosuppressive Therapy ◽  
Plasma Levels ◽  
Filtration Rate ◽  
Inflammatory Process ◽  
C Reactive Protein ◽  
Birmingham Vasculitis Activity Score ◽  
Reactive Protein ◽  
Antineutrophil Cytoplasmic Autoantibody

BackgroundOsteopontin is a pleiotropic cytokine involved in the recruitment and retention of neutrophils to sites of inflammation, which are the primary targets cells in antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV). Osteopontin may play a role in the pathogenesis of AAV.Methods24 patients with systemic AAV and six patients with limited granulomatous disease were included. 19 patients were followed up at 6 and 12 months after the initiation of immunosuppressive therapy. 21 matched healthy volunteers and 20 body mass index and glomerular filtration rate-matched patients with IgA nephropathy were included as controls. Plasma levels of osteopontin were measured by ELISA. Disease activity was gauged by the Birmingham vasculitis activity score (BVAS) and C-reactive protein (CRP).ResultsOsteopontin levels are elevated compared with controls (healthy p<0.001; IgA p<0.001).Osteopontin levels decrease significantly during follow-up (p=0.02). Osteopontin levels correlate with disease activity (BVAS r=0.93; CRP r=0.73; all p<0.001) as well as erythrocyturia (r=0.7, p<0.001) and proteinuria (r=0.54, p=0.007).ConclusionsActive AAV is characterised by increased plasma levels of osteopontin, which decrease dramatically with successful therapy. Osteopontin may mediate the inflammatory process in AAV through the recruitment of neutrophils.

scholarly journals Morphofunctional properties of platelets in patients with rheumatoid arthritis

2021 ◽  
pp. 55-61
Author(s):  
Z. V. Zubkova ◽  
I. A. Novikova
Keyword(s):  
Rheumatoid Arthritis ◽  
Platelet Count ◽  
Disease Activity ◽  
Peripheral Blood ◽  
Maximum Degree ◽  
Inflammatory Process ◽  
C Reactive Protein ◽  
Platelet Activity ◽  
Reactive Protein

Objective: to assess the morphofunctional properties of platelets in patients with rheumatoid arthritis (RA) in combination with other clinical and laboratory characteristics of the disease.Materials and methods. The parameters of platelet hemostasis were studied in 51 RA patients with varying degrees of disease activity according to the DAS28 index.Results. It has been found that the count of platelets in the peripheral blood and their aggregation properties depend on the indicators of the activity of the inflammatory process (degree of activity, ESR, level of C-reactive protein). Platelet indices (MPV, P-LCR, PDW) are interrelated with the relative counts of lymphocytes and segmented neutrophils in the peripheral blood. In RA patients who are seropositive for rheumatoid factor, its titer is associated with the morphofunctional properties of platelets (platelet count, MPV, maximum degree of aggregation in the ADP test).Conclusion. The role of platelets in the RA pathogenesis is not limited exclusively to the hemostatic function. The associations we identified between the platelet activity and the clinical and laboratory characteristics of the disease are indicative of their active participation in immunological processes.

scholarly journals Serial Changes in Circulating Concentrations of Soluble CD40 Ligand and C-Reactive Protein in Patients With Unstable Angina Undergoing Coronary Stenting

2005 ◽  
Vol 69 (8) ◽  
pp. 890-895 ◽  
Author(s):  
Hon-Kan Yip ◽  
Chiung-Jen Wu ◽  
Cheng-Hsu Yang ◽  
Hsueh-Wen Chang ◽  
Chih-Yuan Fang ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Cd40 Ligand ◽  
Coronary Stenting ◽  
C Reactive Protein ◽  
Soluble Cd40 Ligand ◽  
Reactive Protein
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