MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF LIVER REGENERATION WHEN USING THE IMPLANT MADE OF TITANIUM NICKELIDE (EXPERIMENTAL STUDY)
The development of medicine all over the world is currently mainly associated with regenerative medicine technologies. The study of regenerative processes in liver under the influence of various factors is relevant. Nickel-titanium implants with shape memory are widely used in surgery. Recently, porous alloys based on titanium nickelide have also been used as implantation materials in various fields of medicine. They are biologically compatible, exhibit hysteresis properties, and are permeable to biological tissues, which is essential for the development of cell and regenerative medicine techniques. In an experimental study, changes in the liver parenchyma were studied when using a clip for clamping parenchymal organs and when using a porous implant. The possibility of targeted liver regeneration using a porous implant was studied. The object of the study was laboratory rats with healthy livers. The animals were operated with these implants applied to the liver. Changes in the liver were studied for 30 days after surgery by histological examination of various parts of it with an assessment of dystrophic and proliferative processes in the liver parenchyma. The study found that implants of titanium nickelide possess the bioinert condition. The undulating structure of the branch clip provides a reduced specific pressure on the pinched tissue and, thus, its injury safety, and compression when pinching the marginal part of the organ is carried out gently, without injury, and leads to a smooth decrease in trophic and atrophy of the tissue of this area. More pronounced atrophy was accompanied by increased regeneration processes, which was accompanied by hypertrophy of hepatocytes, an increase in their nuclei and polyploidization of liver cells.