scholarly journals Stimulation of Liver Regeneration Using a Titanium Nickelide Implant (Experimental Study)

2020 ◽  
Vol 5 (1) ◽  
pp. 78-83
Author(s):  
I. R. Vesir ◽  
G. Ts. Dambaev ◽  
V. E. Gunter ◽  
E. A. Gereng ◽  
A. N. Vusik ◽  
...  
Keyword(s):  
Experimental Study ◽  
Liver Regeneration ◽  
Titanium Nickelide ◽  
Specific Pressure ◽  
Pharmacological Agents ◽  
Laboratory Rats ◽  
Marginal Part ◽  
Liver Changes ◽  
Surgical Stimulation ◽  
Stimulation Of

Currently, morbidity and mortality from chronic diffuse diseases of the liver and cirrhosis continue to increase worldwide. The difficulty of stabilizing the process with pharmacological agents, lots of restrictions for liver transplantation, the palliative character of the surgical correction of complications determine the urgency of finding various ways to stimulate liver regeneration, including surgical ones. Most of the known methods of surgical stimulation of regeneration are quite traumatic, and their stimulating effect is short-lived. The methods associated with cellular technologies are mostly expensive, ineffective, or poorly understood. In the experimental study, the effect on the parenchyma of a healthy and cirrhotic liver clips for clamping parenchymal organs exerting different unit pressure on the tissue was studied. The object of the study was laboratory rats with a healthy liver and animals with simulated cirrhosis. The animals were operated on with the imposition of titanium nickelide clips on the liver. Changes in the liver were studied 3, 7, 14, and 28 days after the surgery by histological examination of various parts of the liver. It was established that the clip with a lower specific pressure did not cause tissue necrosis, led to atrophy of the marginal part of the liver, also increased hepatocytes and binuclear hepatocytes were observed in the bulk of the liver. A decrease in the proportion of connective tissue was also observed in groups with liver cirrhosis. Thus, we consider it possible to use clips with a certain specific pressure on the tissue as a method of stimulating the reparative properties of the liver in chronic diffuse diseases and cirrhosis of the liver

scholarly journals MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF LIVER REGENERATION WHEN USING THE IMPLANT MADE OF TITANIUM NICKELIDE (EXPERIMENTAL STUDY)

2021 ◽  
Vol 10 (3) ◽  
pp. 12-15
Author(s):  
E.A. Gereng ◽  
I.R. Vesir ◽  
T.S. Klyushina
Keyword(s):  
Experimental Study ◽  
Regenerative Medicine ◽  
Liver Regeneration ◽  
Titanium Nickelide ◽  
Liver Parenchyma ◽  
Biological Tissues ◽  
Titanium Implants ◽  
Laboratory Rats ◽  
Porous Implant ◽  
Liver Changes

The development of medicine all over the world is currently mainly associated with regenerative medicine technologies. The study of regenerative processes in liver under the influence of various factors is relevant. Nickel-titanium implants with shape memory are widely used in surgery. Recently, porous alloys based on titanium nickelide have also been used as implantation materials in various fields of medicine. They are biologically compatible, exhibit hysteresis properties, and are permeable to biological tissues, which is essential for the development of cell and regenerative medicine techniques. In an experimental study, changes in the liver parenchyma were studied when using a clip for clamping parenchymal organs and when using a porous implant. The possibility of targeted liver regeneration using a porous implant was studied. The object of the study was laboratory rats with healthy livers. The animals were operated with these implants applied to the liver. Changes in the liver were studied for 30 days after surgery by histological examination of various parts of it with an assessment of dystrophic and proliferative processes in the liver parenchyma. The study found that implants of titanium nickelide possess the bioinert condition. The undulating structure of the branch clip provides a reduced specific pressure on the pinched tissue and, thus, its injury safety, and compression when pinching the marginal part of the organ is carried out gently, without injury, and leads to a smooth decrease in trophic and atrophy of the tissue of this area. More pronounced atrophy was accompanied by increased regeneration processes, which was accompanied by hypertrophy of hepatocytes, an increase in their nuclei and polyploidization of liver cells.

Effect of reverse thermoelastic phase transformation on stress of onset of structural deformation in titanium nickelide

2021 ◽  
pp. 2-10
Author(s):  
A. A. Movchan ◽  
◽  
S. A. Kazarina ◽  
A. L. Silchenko ◽  
◽  
...  
Keyword(s):  
Experimental Study ◽  
Phase Transformation ◽  
Inelastic Deformation ◽  
Titanium Nickelide ◽  
Structural Deformation ◽  
Isotropic Hardening ◽  
Reverse Phase ◽  
Maximum Value ◽  
Study Results ◽  
Thermoelastic Phase Transformation

The experimental study results of the dependence in the stress value of the onset of the structural deformation on the degree of the reverse phase transformation occurring after the complete direct martensitic transformation in titanium nickelide are described. It is established that these results are qualitatively and quantitatively correctly described in the framework of the model according to which the maximum value of the intensity of the intrinsic inelastic deformation of the martensitic part of the representative volume of the shape-memory alloy is used as a parameter of isotropic hardening.

scholarly journals NEURONAL-GLIAL MEMBRANE CONTACTS DURING PESSIMAL ELECTRICAL STIMULATION

2020 ◽  
Vol 28 (3) ◽  
pp. 35-50
Author(s):  
Oleg S. Sotnikov ◽  
Svetlana S. Sergeeva ◽  
Tat'yana I. Vasyagina
Keyword(s):  
Electrical Stimulation ◽  
Gap Junctions ◽  
De Novo ◽  
Laboratory Rats ◽  
Transmission Electron ◽  
Layer Structures ◽  
Dense Substance ◽  
Membrane Contacts ◽  
Glial Membrane ◽  
Stimulation Of

After the creation of a method for obtaining inter-neuronal gap junctions in a nervous system devoid of glia, it is expedient to reproduce gap neuronal-glial contacts on a model that also contains hybrid neuronal-glial gap junctions, which, as you know, are functionally fundamentally different from inter-neuronal contacts. The experiments were carried out on the truncus sympathicus ganglia of laboratory rats using pessimal electrical stimulation and transmission electron microscopy. Electrical activation of ganglia with a frequency of up to 100 Hz revealed local and widespread variants of various neuronal-glial connections (contacts, bridges), fringed with peri-membrane filamentous proteins. They had a blurred veil that masked two-layer neuro-membranes. Some of the contacts resembled slit or dense 5-layer structures without a visible inter-neuronal slit, but with an extreme decrease in the thickness of the contact slit. The main result of the experiments was the formation, in addition to slotted, multiple septate (ladder) contacts. Relatively independent aggregates of the electron-dense substance of the septa were located inside the intercellular gaps, crossing both adjacent membranes, and, possibly, permeate of them. Near-membrane, poorly outlined pyramid-like protein cones associated with both cell membranes were also formed. Such membranes appeared to be dotted-dashed, that is, not continuous. A significant number of septic contact membranes had endocytic invaginations (invaginations) facing neuroplasm with pyramid-like marginal projections. All reactive altered structures that have arisen de novo are considered by the authors as developed under the influence of frequency electrical stimulation of denaturation and aggregation of intrinsic and perimembrane proteins.

scholarly journals The effect of laser on the stimulation of bone-implant interaction: an experimental study in rabbits

2011 ◽  
Vol 26 (3) ◽  
pp. 242-246
Author(s):  
Kleber Ricardo Monteiro Meyer ◽  
Marco Antonio Rambo Osório ◽  
Sabrina Rebollo Zani ◽  
Eduardo Rolim Teixeira
Keyword(s):  
Experimental Study ◽  
Bone Implant ◽  
Stimulation Of

scholarly journals Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 197 ◽  
Author(s):  
Dominika Maciejewska ◽  
Joanna Palma ◽  
Karolina Dec ◽  
Karolina Skonieczna-Żydecka ◽  
Izabela Gutowska ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vaccenic Acid ◽  
Dietary Exposure ◽  
Docosapentaenoic Acid ◽  
Control Group ◽  
Study Group ◽  
Sprague Dawley ◽  
Laboratory Rats ◽  
Fatty Acids Profile ◽  
Liver Changes

Background: Existing data show a correlation between the profile of fatty acids, liver, and blood. Therefore, the aim of our study was to investigate the correlation between the fatty acids profile in blood pallets and the liver. Methods: The experiment was performed on 60 eight-week-old male Sprague-Dawley rats. The study group (n = 30, 5 groups, 6 rats each) received a cholesterol diet; the control group (n = 30, 5 groups, 6 rats each) received standard food for laboratory rats. The rats from both the study and control groups were sacrificed after 2, 4, 8, 12, and 16 weeks of dietary exposure. The fatty acids profile was measured using gas chromatography (GC). Results: In both the control and study group, the highest correlations were observed in palmitoleic acid (RHO = 0.68), heptadecanoic acid (RHO = 0.65), vaccenic acid (RHO = 0.72), eicosapentaenoic acid (RHO = 0.68), docosapentaenoic acid (RHO = 0.77), and docosahexaenoic (RHO = 0.77). Among liver indexes, the highest correlations were desaturase-18 (0.61). Conclusions: Fatty acids profile is a sensitive marker of the development of potentially pathological changes in the liver. The potential markers of fatty liver are: oleic acid, vaccenic acid, EPA, DHA, docosapentaenoic acid, and desaturase index (SCD-18 index).

Options at the fundamental level for growth regulation in farm livestock

1997 ◽  
Vol 1987 ◽  
pp. 22-22
Author(s):  
P. J. Reeds
Keyword(s):  
Growth Regulation ◽  
Genetic Manipulation ◽  
Growth Promotion ◽  
Cellular Mechanisms ◽  
Pharmacological Agents ◽  
New Developments ◽  
Protein Deposition ◽  
Effective Use ◽  
Farm Livestock ◽  
Stimulation Of

New developments in immunological techniques and increasing expertise in genetic manipulation, especially by gene transfer, have opened up a wide variety of approaches to the manipulation of the growth and metabolism of farm livestock. However, the most effective use of these techniques and the design of new pharmacological agents for growth promotion and nutrient “repartitioning” might well rest on a greater understanding of the factors and cellular mechanisms that coordinate growth and protein anabolism. It is this coordidnation that must be disturbed if persistent gains are to bke made. This greater understanding may well result from an examination of the mechanisms whereby currently available anabolic agents and techniques exert their effects and this paper will draw on these experiences. Growth is clearly a closely coordinated process and this has hampered many attempts to maintain accelerated protein deposition for long periods. For example forced increases in hormonal concentrations often induce hormonal insensitivity. It is possible that understanding and reducing the constraints on growth for example by reducing the levels of suppressive factors rather than concentrating on the active stimulation of anabolic factors may be more effective.

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