The Effects of Insulin and Strontium Ranelate on Guided Bone Regeneration in Diabetic Rats

2017 ◽  
Vol 68 (4) ◽  
pp. 693-697
Author(s):  
Alexandru Nemtoi ◽  
Vlad Danila ◽  
Eliza Dragan ◽  
Sorin Pasca ◽  
Ana Nemtoi ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Strontium Ranelate ◽  
Wistar Rats ◽  
Proximal Tibia ◽  
Guided Bone Regeneration ◽  
Diabetic Rats ◽  
Average Weight ◽  
Bone Augmentation ◽  
Histomorphometric Analysis

The aim of this study was to investigate the effect of insulin and strontium ranelate treatment on guided bone regeneration in diabetic rats. This study was carried out on 30 adult Wistar rats with an average weight of 250-300 grams. The animals underwent a unilateral osteotomy of the left proximal tibia followed by bone augmentation with collagenized porcine bone xenografts (Osteobiol� mp3, Tecnoss Dental s.r.l., Torino, Italy) and then were randomized into five groups: healthy (H), diabetes (D), diabetes with insuline (DI), diabetes with strontium ranelate (DS) and diabetes with insuline and strontium ranelate (DIS). Histomorphometric analysis was performed at the end of this study.

Additive manufacturing to assist prosthetically guided bone regeneration of atrophic maxillary arches

2015 ◽  
Vol 21 (6) ◽  
pp. 705-715 ◽  
Author(s):  
M. Fantini ◽  
F. De Crescenzio ◽  
L. Ciocca ◽  
F. Persiani
Keyword(s):  
Additive Manufacturing ◽  
Bone Regeneration ◽  
Dental Implants ◽  
Surgical Intervention ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Virtual Planning ◽  
Content Type ◽  
Fused Deposition

Purpose – The purpose of this paper is to describe two different approaches for manufacturing pre-formed titanium meshes to assist prosthetically guided bone regeneration of atrophic maxillary arches. Both methods are based on the use of additive manufacturing (AM) technologies and aim to limit at the minimal intervention the bone reconstructive surgery by virtual planning the surgical intervention for dental implants placement. Design/methodology/approach – Two patients with atrophic maxillary arches were scheduled for bone augmentation using pre-formed titanium mesh with particulate autogenous bone graft and alloplastic material. The complete workflow consists of four steps: three-dimensional (3D) acquisition of medical images and virtual planning, 3D modelling and design of the bone augmentation volume, manufacturing of biomodels and pre-formed meshes, clinical procedure and follow up. For what concerns the AM, fused deposition modelling (FDM) and direct metal laser sintering (DMLS) were used. Findings – For both patients, a post-operative control CT examination was scheduled to evaluate the progression of the regenerative process and verify the availability of an adequate amount of bone before the surgical intervention for dental implants placement. In both cases, the regenerated bone was sufficient to fix the implants in the planned position, improving the intervention quality and reducing the intervention time during surgery. Originality/value – A comparison between two novel methods, involving AM technologies are presented as viable and reproducible methods to assist the correct bone augmentation of atrophic patients, prior to implant placement for the final implant supported prosthetic rehabilitation.

scholarly journals Bone augmentation at peri-implant dehiscence defects comparing a synthetic polyethylene glycol hydrogel matrix vs. standard guided bone regeneration techniques

2016 ◽  
Vol 28 (7) ◽  
pp. e76-e83 ◽  
Author(s):  
Daniel S. Thoma ◽  
Ui-Won Jung ◽  
Jin-Young Park ◽  
Stefan P. Bienz ◽  
Jürg Hüsler ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Bone Augmentation ◽  
Hydrogel Matrix

Vertical Bone Augmentation with an Autogenous Block or Particles in Combination with Guided Bone Regeneration: A Clinical and Histological Preliminary Study in Humans

2015 ◽  
Vol 18 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Isabella Rocchietta ◽  
Massimo Simion ◽  
Maria Hoffmann ◽  
Davide Trisciuoglio ◽  
Marco Benigni ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Bone Augmentation ◽  
Preliminary Study

scholarly journals BAG S53P4 putty as bone graft substitute – a rabbit model

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Ilkka Saarenpää ◽  
Patricia Stoor ◽  
Janek Frantzén
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Proximal Tibia ◽  
Rabbit Model ◽  
Bone Graft Substitute ◽  
Control Group ◽  
The Novel ◽  
Bone Augmentation ◽  
New Bone Formation ◽  
New Zealand White Rabbits

AbstractBioactive glass (BAG) S53P4 granules represent a bone augmentation biomaterial for the surgical treatment of bony defects, even in challenging conditions such as osteomyelitis. The aim of this eight-week rabbit implantation study was to evaluate the biocompatibility and bone regeneration performance of a BAG S53P4 putty formulation following its implantation into the proximal tibia bone of twenty-eight New Zealand white rabbits. BAG S53P4 putty was compared to BAG S53P4 granules (0.5-0.8 mm) to evaluate whether the synthetic putty binder influences the bone regeneration of the osteostimulative granules. The putty formulation facilitates clinical use because of its mouldability, injectability and ease of mixing with autograft. Implantation of putty and granules into proximal tibia defects resulted in good osseointegration of the two groups. Both biomaterials were biocompatible, showed high new bone formation, high vascularization and periosteal growth. No signs of disturbed bone formation were observed due to the PEG-glycerol binder in the BAG S53P4 putty. Instead, intramedullary ossification and stromal cell reaction were more advanced in the putty group compared to the control group (p = 0.001 and p < 0.001). In conclusion, the novel mouldable BAG S53P4 putty showed reliable bone regeneration in bony defects without adverse tissue or cell reactions.

scholarly journals Guided Bone Regeneration- A Comprehensive Review

2021 ◽  
Author(s):  
Vineetha Venugopalan ◽  
Anegundi Raghavendra Vamsi ◽  
Santhosh Shenoy ◽  
Karishma Ashok ◽  
Biju Thomas
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Primary Stability ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Bony Defect ◽  
Graft Material ◽  
Bone Augmentation ◽  
Wide Range ◽  
Space Maintenance

Successful implant treatment requires prosthetically driven placement of an implant, primary stability at placement, and careful living bone management. The resorptive changes of alveolar bone are an inevitable process following tooth loss, periodontal disease or trauma which causes bone defects. This results in various aesthetic and functional complications such as soft tissue recession, infection and inflammation. Various methods have been tried and advocated for augmenting these bone deficiencies. Guided Bone Regeneration (GBR) is a successful modality for bone augmentation with a wide range of indications and helps restore the alveolar ridge dimensions. It utilises the principle of Guided Tissue Regeneration (GTR) for space maintenance within a bony defect. Different types of barrier membranes are being utilised along with various bone grafts in GBR. Thorough knowledge regarding the biology of bone is required before the initiation of any bone augmentation procedure. A combination of Collagen Membrane (CM) and graft material was found successful for GBR. Hence, this review focuses on presentation of best available evidence for various aspects of GBR.

Guided Bone Regeneration, Platelet Rich Plasma and Low-Intensity Ultrasound Irradiation for Dental Implants

2006 ◽  
Vol 49 ◽  
pp. 171-180 ◽  
Author(s):  
Kuniteru Nagahara ◽  
Toshiichiro Tanabe ◽  
Noriaki Ito ◽  
Motohiko Nagayama ◽  
Kota Takagi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Dental Implant ◽  
Platelet Rich Plasma ◽  
Guided Bone Regeneration ◽  
Autogenous Bone ◽  
Bone Block ◽  
Bone Augmentation ◽  
Basic Study ◽  
Low Intensity

Because a concept of an osteointegrated dental implant system was established, prognosis of a dental implant at treatment improved and the treatment of restoration for missing teeth was changed. However, a dental implant treatment into atrophic jaw bone requires bone augmentation, obviously. At this time, we studied for the purpose of establishing the evidence of each method for clinical application of these bone augmentation method, such as guided bone regeneration (GBR), and autogenous bone block graft (BBG). In addition, we pursued the basic study of the evidence about the bone formation with platelet rich plasma (PRP) which recognized the availability in clinic. Furthermore, we present the results of basic studies which we tested for the purpose of applying a low-intensity pulse ultrasound (LIPU) irradiation applied to a fracture treatment in orthopedics area to intra-oral area, specially the condition after implant placement. In the results of comparison with GBR site and BBG, the differences of labeling bands were observed with a fluorescence microscopy. There was much labeling bands on GBR sections in comparison with BBG. This meaning that the bone remodeling around implants at GBR site was more active than BBG site. And the new bone formation by PRP was identified on soft X-ray graphically at first week after PRP applied mandible bone defect (experimental side). At same region of first week specimen, we confirmed positive reactions of platelet derived growth factor

scholarly journals Combined use of xenogenous bone blocks and guided bone regeneration for three-dimensional augmentation of anterior maxillary ridge: A case series

2019 ◽  
Vol 11 (2) ◽  
pp. 94-98
Author(s):  
Mohammadreza Talebi ◽  
Noushin Janbakhsh
Keyword(s):  
Bone Regeneration ◽  
Primary Closure ◽  
Three Dimensional ◽  
Case Series ◽  
Guided Bone Regeneration ◽  
Alveolar Ridge ◽  
Bone Augmentation ◽  
3 Dimensional ◽  
Ridge Augmentation ◽  
Combined Use

Background. Bone augmentation ensures a favorable 3-dimensional position of implants. Onlay grafting is one of the techniques in ridge augmentation, which can be performed with the use of xenogenous blocks. Methods. Three cases of the vertical and horizontal ridge are discussed, which were augmented using xenogenous blocks. The blocks were shaped in a favorable size and puzzled along the grafting area. All the gaps were filled with granular xenografts. The flaps were coronally advanced to obtain primary closure. Results. An average of 4.2-mm gain in width and 4.2-mm gain in height of the ridge was observed at the implantation stage. Conclusion. The outcomes of these cases could pave the way for suggesting xenograft blocks for augmenting wide areas of the alveolar ridge on average of 4 mm in width and height in selected cases as an alternative to standard autogenous blocks. Long-lasting xenograft ensures implant and lip support in the esthetic zone.

scholarly journals A Preshaped Titanium Mesh for Guided Bone Regeneration with an Equine-Derived Bone Graft in a Posterior Mandibular Bone Defect: A Case Report

2019 ◽  
Vol 7 (3) ◽  
pp. 77
Author(s):  
Danilo Alessio Di Stefano ◽  
Gianbattista Greco ◽  
Enrico Gherlone
Keyword(s):  
Bone Regeneration ◽  
Bone Biopsy ◽  
Guided Bone Regeneration ◽  
Bone Augmentation ◽  
Titanium Mesh ◽  
Augmentation Techniques ◽  
Stereolithographic Model ◽  
Regeneration Procedure ◽  
Light Curing

One of the most often used bone augmentation techniques is the guided bone regeneration procedure. The authors report the case of a 75-year-old man with an atrophic right posterior mandible who underwent bone augmentation through guided bone regeneration with a preshaped titanium mesh adapted on a stereolithographic model of the patient’s jaw. The graft volume was simulated with a light-curing resin. The actual site was grafted with a mixture of autogenous and equine-derived bone. Five months later, the mesh was retrieved, three cylindrical implants were positioned, and a bone biopsy was collected for histomorphometric analysis. A provisional prosthesis was delivered three and a half months later. Definitive rehabilitation was accomplished after one additional month. The graft allowed for effective bone formation (newly formed bone, residual biomaterial, and medullar spaces were, respectively, 39%, 10%, and 51% of the core volume). The patient has functioned successfully throughout six and a half years of follow-up. Using the preshaped titanium mesh in association with the enzyme-treated equine bone substitute provided effective bone regeneration.

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