Pharmaceutically Active Compounds Degradation Using Doped TiO2 Functionalized Zeolite Photocatalyst

2018 ◽  
Vol 69 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Monica Ihos ◽  
Corneliu Bogatu ◽  
Carmen Lazau ◽  
Florica Manea ◽  
Rodica Pode

The aim of this study was the investigation of photocatalytic degradation of pharmaceutically active compounds using doped TiO2 functionalized zeolite photocatalyst. Diclofenac (DCF), a non-steroidal anti-inflammatory drug, that represents a biorefractory micropollutant, was chosen as model of pharmaceutically active compound. The photocatalyst was Z-TiO2-Ag. The concentration of DCF in the working solutions was 10 mg/L,50 mg/L,100 mg/L and 200 mg/L and of photocatalyst 1 g/L in any experiments. The process was monitored by recording the UV spectra of the treated solutions and total organic carbon (TOC) determination. The UV spectra analysis and TOC removal proved that along the advanced degradation of DCF also a mineralization process occurred. The carried out research provided useful information envisaging the treatment of pharmaceutical effluents by photocatalysis.

2013 ◽  
Vol 13 (5) ◽  
pp. 1348-1357 ◽  
Author(s):  
Sabrina Diemert ◽  
Robert C. Andrews

This study assessed the impact of chemical coagulation using alum on the removal of three endocrine-disrupting compounds (EDCs; bisphenol A, clofibric acid and estriol) and nine pharmaceutically active compounds (PhACs; acetaminophen, carbamazepine, diclofenac, gemfibrozil, ketoprofen, naproxen, pentoxifylline, sulfamethoxazole and sulfachloropyridazine). The impact on natural organic matter (NOM) fractions as determined using liquid chromatography–organic carbon detection (LC–OCD; total dissolved organic carbon (DOC), hydrophobic DOC, biopolymers, humic substances, building blocks, low molecular weight neutrals and acids) was also examined. Three test surface waters were included: Lake Ontario, Grand River and Otonabee River water (Ontario, Canada). Gemfibrozil concentrations were reduced in both Otonabee and Grand River waters. Reductions were noted for carbamazepine and (inconsistently) for acetaminophen, and estrone appeared to increase in concentration in Grand River water with increasing alum doses. NOM removal was primarily attributed to the humic fraction, with small reductions in biopolymers in all of the waters studied.


2020 ◽  
Vol 14 (1) ◽  
pp. 21-39
Author(s):  
Anupama Singh ◽  
Vandana Kharb ◽  
Vikas Anand Saharan

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve or disintegrate quickly, leading to fast distribution of active ingredients at the site of administration; thereby providing ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. With time, the use of FDDFs in alternative systems has significantly increased. Homeopathic systems and traditional Chinese medicine have embraced FDDFs for the delivery of active compounds. Most of the patents in this area are from China or by the Chinese innovators. In Europe and US, FDDFs have been extensively studied for the delivery of natural active compounds. It was fascinating to know that some new dosage forms and new routes of delivering active compounds are also making their way to the family of FDDFs. The dose of active compound, size of dosage forms, standardization of extracts, polyherbal mixtures, stability of active compounds, safety, efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or phytopharmaceuticals.


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