Effect of Agaricus blazei β-Glucan and Egg Shell Calcium Complex on Bone Metabolism in Ovariectomized Rats

2006 ◽  
Vol 35 (10) ◽  
pp. 1363-1370
Keyword(s):  
Bone Metabolism ◽  
Ovariectomized Rats ◽  
Agaricus Blazei ◽  
Egg Shell

scholarly journals The Antiosteoporotic Activity of Central-Icaritin (CIT) on Bone Metabolism of Ovariectomized Rats

Molecules ◽  
2014 ◽  
Vol 19 (11) ◽  
pp. 18690-18704 ◽  
Author(s):  
Jun Jiang ◽  
Jie Li ◽  
Xiaobin Jia
Keyword(s):  
Bone Metabolism ◽  
Ovariectomized Rats

scholarly journals Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Wenna Liang ◽  
Xihai Li ◽  
Guanhui Li ◽  
Liu Hu ◽  
Shanshan Ding ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Crucial Role ◽  
Molecular Mechanisms ◽  
Bone Biomechanics ◽  
Ovariectomized Rats ◽  
Therapeutic Effects ◽  
Bone Morphology ◽  
Mineral Density ◽  
Metabolism Disorder ◽  
Successful Establishment

Background. Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China. However, its molecular mechanisms remain unclear. The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP. We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model. We then investigated the expression of biomarkers related to the Sirt1/Foxo axis. We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression. The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration. The antiosteoporotic effect of EZP was confirmed. We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration. And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration. These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.

scholarly journals Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

2017 ◽  
Author(s):  
Saki Shimizu ◽  
Hiroshi Matsushita ◽  
Yuko Morii ◽  
Yuriko Ohyama ◽  
Noriko Morita ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Ovariectomized Rats ◽  
Bilberry Extract

scholarly journals Zhuang-Gu-Fang Treats Osteoporosis in Ovariectomized Rats by Increasing the Osteogenesis-Related Factors Leptin, Ghrelin, and PYY

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Yuanjin Chen ◽  
Rui Bai ◽  
Wenhui Chen ◽  
Shuanglei Li ◽  
Yunxia Jiang
Keyword(s):  
Bone Metabolism ◽  
Therapeutic Effect ◽  
Wistar Rats ◽  
Dose Group ◽  
Bone Structure ◽  
Ovariectomized Rats ◽  
Type I ◽  
Mineral Density ◽  
Related Factors ◽  
Expression Levels

Zhuang-Gu-Fang is a Chinese medicinal compound mixture, which is mainly composed of traditional remedies like the Epimedium Herb, Astragalus, and Eucommia among many others. The study is aimed at investigating the therapeutic effect of Zhuang-Gu-Fang in ovariectomized rats. Fifty six-month-old Wistar rats were randomly selected and divided into 5 groups (n = 10), namely, model group, positive group, low-dose Chinese medicine group, medium-dose group, and high-dose group. Another 10 sham operation Wistar rats were taken as a negative control group. After 3 months of intervention, the bone mineral density (BMD), procollagen type I N-peptide (PINP), beta C-terminal cross-linked telopeptides of type I collagen carboxyl-terminal peptide (β-CTX), Leptin, Ghrelin, and Peptide YY (PYY) of each group were measured. Besides, the ultrastructure of bone structure and osteoblasts was also observed by transmission electron microscopy. Western blot method was used to detect the expression levels of Leptin and Ghrelin in bone tissue, and RT-PCR detected the mRNA expression levels of Leptin and Ghrelin. BMD test indicated that Zhuang-Gu-Fang could effectively prevent the loss of tibia bone in ovariectomized rats. Histomorphology analysis showed that Zhuang-Gu-Fang could preserve trabecular bone structure integrity and improve osteoblast ultrastructure. Notably, the study found out that Zhuang-Gu-Fang worked through balancing the bone metabolism via increasing bone formation/resorption ratio. Additionally, Zhuang-Gu-Fang highlighted the recovery effects in multiple levels of osteogenesis- and osteanagenesis-related factors Leptin, Ghrelin, and PYY. Conclusively, the study proved the therapeutic potential of the Zhuang-Gu-Fang for postmenopausal osteoporosis (PMOP) and further revealed that its therapeutic effect was related to the balance of bone metabolism and the recovery effects of bone-related factors Leptin, Ghrelin, and PYY.

Effect of Shellfish Calcium on the Apparent Absorption of Calcium and Bone Metabolism in Ovariectomized Rats

1999 ◽  
Vol 63 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Takehito MIURA ◽  
Yasuyoshi TAKAYAMA ◽  
Masuo NAKANO
Keyword(s):  
Bone Metabolism ◽  
Ovariectomized Rats ◽  
Apparent Absorption

scholarly journals Effects of Chronic Estrogen Administration in the Ventromedial Nucleus of the Hypothalamus (VMH) on Fat and Bone Metabolism in Ovariectomized Rats

Endocrinology ◽  
2016 ◽  
Vol 157 (12) ◽  
pp. 4930-4942 ◽  
Author(s):  
Z. Zhang ◽  
J. Liu ◽  
A. G. Veldhuis-Vlug ◽  
Y. Su ◽  
E. Foppen ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Ovariectomized Rats ◽  
Ventromedial Nucleus ◽  
Estrogen Administration

scholarly journals Effects of a Fermented Vegetable Product on Fat Deposition and Bone Metabolism in Ovariectomized Rats

2004 ◽  
Vol 50 (6) ◽  
pp. 422-425 ◽  
Author(s):  
Takashi SHIMADA ◽  
Chie MOTONAGA ◽  
Shingoro MATSUURA ◽  
Masahiro TAKAGAKI ◽  
Takayuki ASHIDA ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Fat Deposition ◽  
Ovariectomized Rats ◽  
Vegetable Product

scholarly journals Effects of silk fibroin hydrolysate on bone metabolism in ovariectomized rats

2015 ◽  
Vol 30 (1) ◽  
pp. 17-25 ◽  
Author(s):  
HaeYong Kweon ◽  
Sun Hee Shin ◽  
Jeong-Woo Chon ◽  
Kwang-Gill Lee ◽  
You-Young Jo ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Silk Fibroin ◽  
Ovariectomized Rats
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