THE ASSOCIATION OF THE APOLIPOPROTEIN E4 ALLELE (RS 429358) WITH OVARIAN SEROUS ADENOCARCINOMA

2017 ◽  
Vol 63 (4) ◽  
pp. 627-631
Author(s):  
Tatyana Ivanova ◽  
Nataliya Sychenkova ◽  
Vera Khorokhorina ◽  
Nikolay Ryabchenko ◽  
Sergey Ivanov ◽  
...  
Keyword(s):  
Older Women ◽  
Odds Ratio ◽  
Area Under Curve ◽  
Reproductive Age ◽  
Prognostic Indicators ◽  
Separate Analysis ◽  
Women Of Reproductive Age ◽  
Serous Adenocarcinoma ◽  
Ovarian Serous Adenocarcinoma ◽  
E4 Allele

The distribution of APOE 4 allele (rs 429358, C) was analyzed in healthy women (N=454) and patients with ovarian serous adenocarcinoma (N=114) in order to identify genetic predisposition to the disease. We determined the prognostic indicators of the E4 allele as a marker: odds ratio (OR) and AUC (Area Under Curve) - an area under the ROC curve. It was shown that APOE 4 allele was significantly associated with ovarian serous adenocarcinoma (p = 0,003; 0R=1,94; AUC=0,55). The Е4 genotypes frequency was significantly increased among patients (p = 0.02; 0R=1,8). Separate analysis of the two age subgroups (over 46 years and younger) found that the chance of developing ovarian serous adenocarcinoma was significantly increased for older women (p = 0,006; OR = 2,24, AUC = 0,76). Possible associations of APOE 4 with the ovarian serous adenocarcinoma in women of reproductive age deserve further studying.

scholarly journals Prevalence of anemia and sociodemographic characteristics among pregnant and non-pregnant women in southwest China: a longitudinal observational study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu Wu ◽  
Hanfeng Ye ◽  
Jihong Liu ◽  
Qiuyue Ma ◽  
Yanling Yuan ◽  
...  
Keyword(s):  
Observational Study ◽  
Pregnant Women ◽  
Odds Ratio ◽  
Southwest China ◽  
First Trimester ◽  
Reproductive Age ◽  
Sociodemographic Characteristics ◽  
Women Of Reproductive Age ◽  
Longitudinal Observational Study ◽  
Prevalence Of Anemia

Abstract Background Globally, the prevalence of anemia among women of reproductive age is about 29.4%, and anemia impacts about 40% of pregnant women and more than 20% of non-pregnant women. We conducted a longitudinal observational study of anemia in pregnant and non-pregnant women, and analyzed the association between the prevalence of anemia and sociodemographic characteristics of women in southwest China. Methods This study was a longitudinal observational study which involved 640,672 women aged 18–49 years from 129 counties in southwest China. Data were from databases of National Free Preconception Health Examination Project (NFPHEP) and electronic medical records of local hospitals. We adjusted the diagnostic thresholds of anemia for altitude. The prevalence of anemia was expressed in percentages and 95% confidence intervals (95% CI). The association between the prevalence of anemia and sociodemographic characteristics of pregnant and non-pregnant women were analyzed using univariate and multivariate logistic regression method, expressed in crude odds ratio (cOR), adjusted odds ratio (aOR) and 95%CI. Results Of the 640,672 participants, 121,254 women suffered from anemia, with the prevalence of 18.9% (95%CI: 18.8–19.0%). From 2014 to 2018, the prevalence of anemia declines from 23.0–16.4%.The prevalence was 21.6% in the first trimester, higher than women in non-pregnancy (17.4%) and women in the third trimester (10.5%). Results from the multivariable logistic regression showed that women aged 18–20 (aOR = 1.28) or over 35 years old (aOR = 1.07), being farmers (aOR = 1.42), being ethnic minorities (aOR: 1.19 ~ 1.73), during the first trimester (aOR = 1.32) were more likely to be anemic. Conclusions Although the anemia prevalence of women of reproductive age has been decreasing in recent years, the prevalence of anemia is still high in pregnant and non-pregnant women in southwest China, especially during the first trimester. Women who were older or younger, being farmers, being ethnic minorities were at high risk of anemia. Anemia in women of reproductive age cannot be neglected.

scholarly journals Prevalence of modern contraceptive utilization and associated factors among women of reproductive age from 36-49 years in Ethiopia

2019 ◽  
Author(s):  
Dereje Zena Asrat ◽  
Anemaw Asrat Achamyeleh ◽  
Agumas Fentahun Ayalew
Keyword(s):  
Odds Ratio ◽  
Associated Factors ◽  
Adjusted Odds Ratio ◽  
Statistical Significance ◽  
Reproductive Age ◽  
Modern Contraceptive ◽  
Women Of Reproductive Age ◽  
Number Of Children ◽  
Contraceptive Services ◽  
Contraceptive Utilization

Abstract Background: One of the major problems in developing countries is the increasing growth of population which in fact is a serious threat for the global community. Modern Contraceptive use allows people to attain their desired number of children and determine the spacing of pregnancies. The main objective of this study is to assess the Prevalence of modern contraceptive utilization and associated factors among women of reproductive age from 36-49 years in Ethiopia. Methodology: A community based, cross-sectional study was employed from January 1 to June 30, 2016, among women of reproductive age from 36-49 years in all regions of Ethiopia. A multi-stage sampling procedure was used to select 3260 study participants. A pretested structured questionnaire was used to collect data, and data collectors who had completed high school were involved in the data collection process. A bivariate, multivariable logistic regression model was fit and statistical significance was determined with odds ratios and 95 % confidence level. Before preceding data analysis, the necessary assumptions for the application of multiple logistic regressions was checked by Hosmer and Lemeshow Test through forward LR method. Result: The overall modern contraceptive prevalence rate was found to be 17%. Being wealthy (Adjusted Odds Ratio=4.120 95%CI (2.853, 5.949), higher educated (Adjusted Odds Ratio =3.329, 95%CI (2.065, 5.368) and having more numbers of living children (Adjusted Odds Ratio =1.714, 95% (1.328, 2.212) was significantly associated with use of modern contraceptive methods. Conclusion: The utilization of modern contraceptive method was low. Contraceptive utilization was associated with some socio-economic and socio-demographic factors like age, educational status, women wealth index and number of children. Therefore, expanding contraceptive services confers substantial benefits on women, their families and society. All stakeholders, including the Ethiopian government and the private sector, should increase their investment in modern contraceptive services Keywords: modern Contraceptives use, Associated Factors and Women

scholarly journals Passive Transfer Of Allo-Antibodies Following Rhig Administration Given For Rh-Mismatched Platelets Prophylaxis

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S158-S159
Author(s):  
N Sostin ◽  
J Hendrickson ◽  
R Balbuena-Merle ◽  
C Tormey
Keyword(s):  
Older Women ◽  
Retrospective Review ◽  
Case Series ◽  
Passive Transfer ◽  
Human Platelets ◽  
Reproductive Age ◽  
New Haven ◽  
Women Of Reproductive Age ◽  
Antibody Screen ◽  
Haven Hospital

Abstract Introduction/Objective Human platelets (PLTs) do not express any Rh system antigens; however, PLT concentrates can be contaminated with small amounts of red blood cells (RBCs), which may induce alloimmunization when transfused to Rh(D)-negative individuals. RhIG has been utilized to prevent Rh(D) alloantibody development following transfusion of Rh mismatched PLTs. RhIG is manufactured using pooled plasma of healthy Rh(D)-negative donors, with the most common Rh haplotype being ce; treated subjects are exposed to Rh (D)-positive RBCs, with the most common Rh haplotype of donors being DCe. In this report, we detail our experiences with recipients of Rh mismatched apheresis PLTs who were noted to develop anti-D + anti-C post-RhIG administration. Methods Retrospective review was conducted of all Rh mismatched PLTs between December, 2018 and May, 2019 at our facility (Yale-New Haven Hospital, New Haven, CT). Inclusion in the study required: Rh(D)-negative donor receiving one or more Rh(D)-positive apheresis PLTs, Receiving RhIG, >1 antibody screen following RhIG administration demonstrating antibodies other than anti-D Results Our retrospective review identified 8 unique recipients of Rh mismatched apheresis PLTs who acquired anti- C, in addition to the expected anti-D, following administration of RhIG. The product (Rhophylac) was administered in all cases intravenously at a dose of 1500 IU (300 mcg) within 72 hours following Rh mismatched PLTs. In all patients, routine screening following RhIG simultaneously detected anti-D and anti-C 1-3 days after administration of Rh mismatched PLTs/RhIG, the antibody screen remained positive for a range of 27-167 days for both antibodies. Conclusion Based on this case series, which represented entirely men and older women, and coupled with emerging evidence about the extremely low likelihood of D-alloimmunization following Rh mismatched apheresis PLTs,2,3,6 we have changed our practice, limiting immunoprophylaxis for Rh mismatched platelets exclusively to women of reproductive age. The blood bank and apheresis communities should be aware that passive transfer of non-D antibodies is possible when RhIG is dosed and could account for newly-detected non-D alloimmunization events. This phenomenon is another compelling reason to limit RhIG exposure to cases where it is only absolutely clinically necessary.7

scholarly journals Do Older Women of Reproductive Age Have Better Diet Quality than Younger Women of Reproductive Age?

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3830
Author(s):  
Nahal Habibi ◽  
Katherine M. Livingstone ◽  
Suzanne Edwards ◽  
Jessica A. Grieger
Keyword(s):  
Older Women ◽  
Diet Quality ◽  
Food Group ◽  
Dietary Guidelines ◽  
Reproductive Age ◽  
Dietary Intakes ◽  
Dietary Recommendations ◽  
Women Of Reproductive Age ◽  
Younger Women ◽  
Reproductive Aged Women

There is increasing recognition of the importance of nutrition for reproductive health, but little is known regarding the diet quality of younger vs. older reproductive aged women, and how their intakes relate to dietary recommendations. The purpose of the study was to examine the diets of younger (19–35 years old) compared to older (35–50 years old) reproductive aged women, and how they align with dietary recommendations. Women aged 19–50 years from the 2011–13 Australian National Nutrition and Physical Activity Survey were included (n = 2323). Dietary intakes were assessed by a single 24-h dietary recall and were compared to (i) Australian Dietary Guidelines; (ii) Acceptable Macronutrient Distribution for protein, carbohydrates, and fat; and (iii) Dietary Guideline Index (DGI). Regression analyses comparing younger and older women against recommendations were undertaken, with confounders determined a priori. There was no difference between older and younger women in meeting food group recommendations, with 26% of all women meeting recommendations for fruit, and meat and alternatives, and <20% meeting recommendations for vegetables and alternatives, grains, and dairy. Although there was no difference between older and younger women in total DGI score (mean (SE) 75.6 (1.7) vs. 74.5 (2.5), p > 0.05), older women had higher component scores in limiting saturated fat, consuming low-fat milk, and limiting adding salt during cooking. Continued health promotion for women of reproductive age should be a key priority to improve their own health and that of future generations.

scholarly journals Factors associated with modern contraceptive use: a comparative analysis between younger and older women in Umlazi Township, KwaZulu-Natal, South Africa

2021 ◽  
Vol 17 ◽  
pp. 174550652110606
Author(s):  
Mbuzeleni Hlongwa ◽  
Chester Kalinda ◽  
Karl Peltzer ◽  
Khumbulani Hlongwana
Keyword(s):  
Older Women ◽  
Contraceptive Use ◽  
Unplanned Pregnancy ◽  
Reproductive Age ◽  
Modern Contraceptive ◽  
Women Of Reproductive Age ◽  
Level Of Education ◽  
Factors Associated ◽  
Kwazulu Natal ◽  
Modern Contraceptive Use

Introduction: Unplanned pregnancy continues to be a global reproductive and public health concern among women. This study aimed to investigate whether factors associated with modern contraceptive use differ by age-group among young and older women of reproductive age. Methods: This was a cross-sectional study conducted among 433 women of reproductive age, with the median age of 25 years (interquartile range: 21–28), and aged between 18 and 49. Data were collected from 10 public health care clinics in Umlazi Township, KwaZulu-Natal, using a structured questionnaire. Data were coded, entered into Epi Data Manager and exported to Stata for analysis. A Pearson’s chi-square test and logistic regression models were employed to assess the level of the association between the predictor and outcome variables, and the p-value of 0.05 or lower was considered statistically significant. Results: Most women in the sample (n = 351, 81%) had obtained a secondary level of education, while 53% (n = 230) were unemployed and 89% (n = 387) were single. We found that women with secondary level of education (AOR: 2.89, 95% CI: 0.99–5.38) or a tertiary level of education (AOR 3.80, 95% CI: 1.07–3.53) were more likely to use contraceptive methods compared to women with lower education. Women who experienced unplanned pregnancy (AOR 0.51, 95% CI: 0.22–3.79) were more likely to use contraceptives. Women aged 25–49 years who experienced pregnancy, whether planned (AOR 3.87, 95% CI: 1.08–3.89) or unplanned (AOR 3.60, 95% CI: 2.15–4.19), were more likely to use a contraceptive method. Results showed that the level of education (p = 0.942) and whether one experienced unplanned pregnancy (p = 0.913) were not significant predictors of contraceptive use among women aged 18–24 years. Conclusion: Concerted educational efforts to addressing existing barriers deterring women from accessing contraception among young women are necessary. Different groups of women should be targeted with family planning interventions specific to their needs.

scholarly journals Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age

JAMA ◽  
2017 ◽  
Vol 318 (14) ◽  
pp. 1367 ◽  
Author(s):  
Anne Z. Steiner ◽  
David Pritchard ◽  
Frank Z. Stanczyk ◽  
James S. Kesner ◽  
Juliana W. Meadows ◽  
...  
Keyword(s):  
Older Women ◽  
Ovarian Reserve ◽  
Reproductive Age ◽  
Women Of Reproductive Age

scholarly journals Multilevel analysis of factors associated with HIV among women of reproductive age (15–49 years old) in Ethiopia: Bayesian approach

2021 ◽  
Vol 17 ◽  
pp. 174550652110676
Author(s):  
Yilkal Negesse ◽  
Gosa Mankelkl ◽  
Melsew Setegn ◽  
Gossa Fetene
Keyword(s):  
Multilevel Analysis ◽  
Health Facility ◽  
Bayesian Approach ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Reproductive Age ◽  
Rural Resident ◽  
Women Of Reproductive Age ◽  
Long Distance ◽  
Factors Associated

Background: Human immunodeficiency virus remains the leading cause of morbidity and mortality throughout the world. Sub-Saharan Africa regions are the most affected regions and accounted for 67% of HIV infections worldwide, and 72% of the world’s AIDS-related deaths. Objective: To estimate the prevalence of HIV and identify factors associated with it among women of reproductive age in Ethiopia. Methods: This study was conducted based on the 2016 Ethiopian Demographic and Health Surveys data. The data were weighted using sampling weight for probability sampling and non-response to restore the representativeness of the data and get valid statistical estimates. Then, a total of 14,161 weighted sample women were used to investigate the study. Finally, a multilevel analysis was done based on the Bayesian approach to identify factors associated with HIV among women of reproductive age in Ethiopia. Results: This study showed the prevalence of HIV among reproductive age group women was 0.85%. Being rural resident (adjusted odds ratio = 0.20; 95% CrI = 0.1–0.4), secondary education level (adjusted odds ratio = 0.20; 95% CrI = 0.1–0.4), rich wealth status (adjusted odds ratio = 4; 95% CrI = 3–6), married women but living separately (adjusted odds ratio = 2.3; 95% CrI = 1.2–4.5), long distance from the health facility (adjusted odds ratio = 0.4; 95% CrI = 0.3–0.5), and exposure to media (adjusted odds ratio = 2.9; 95% CrI = 1.8–4.7) were significantly associated with HIV. Conclusion: Being rural residents, women whose marital status is separated, wealthy, travel a long distance to get health facility, and are exposed to media are risky to be infected by HIV. Whereas being a rural resident and educated are preventive factors for HIV. Therefore, the government of Ethiopia and the ministry of health should consider those factors when they design HIV prevention and control strategies.

scholarly journals Prevalence of modern contraceptive utilization and associated factors among women of reproductive age from 36-49 years in Ethiopia, 2018: Community based cross-sectional survey

2019 ◽  
Author(s):  
Dereje Zena ◽  
Anemaw Asrat ◽  
Agumas Fentahun
Keyword(s):  
Odds Ratio ◽  
Associated Factors ◽  
Adjusted Odds Ratio ◽  
Reproductive Age ◽  
Modern Contraceptive ◽  
Women Of Reproductive Age ◽  
Community Based ◽  
Cross Sectional ◽  
Number Of Children ◽  
Contraceptive Utilization

Abstract IIntroduction: Modern Contraceptive use allows people to attain their desired number of children and determine the spacing of pregnancies. Objective: The main objective of this study is to assess the Prevalence of modern contraceptive utilization and associated factors among women of reproductive age from 36-49 years in Ethiopia. Methodology: A community based, cross-sectional study was employed from January 1 to June 30, 2016, among women of reproductive age from 36-49 years in all regions of Ethiopia. A bivariate, multivariable logistic regression model was fit and statistical significance was determined with odds ratios and 95 % confidence level. Result: The overall modern contraceptive prevalence rate was found to be 17%. Being wealthy (Adjusted Odds Ratio=4.120 95%CI (2.853, 5.949), higher educated (Adjusted Odds Ratio =3.329, 95%CI (2.065, 5.368) and having more numbers of living children (Adjusted Odds Ratio =1.714, 95% (1.328, 2.212) was significantly associated with use of modern contraceptive methods. Conclusion: The utilization of modern contraceptive method was low. Contraceptive utilization was associated with some socio-economic and socio-demographic factors like age, educational status, women wealth index and number of children. Keywords: modern Contraceptives use, Associated Factors and Women

Evaluation of concomitant gynecological pathology in group of patients of reproductive age with tumors and tumor formations

2020 ◽  
pp. 10-14
Author(s):  
N. V. Spiridonova ◽  
A. A. Demura ◽  
V. Yu. Schukin
Keyword(s):  
Diagnostic Errors ◽  
Ovarian Tumors ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Predisposing Factor ◽  
Ovarian Tumours ◽  
Preoperative Diagnostic ◽  
Neoplastic Process ◽  
History Of ◽  
The Moment

According to modern literature, the frequency of preoperative diagnostic errors for tumour-like formations is 30.9–45.6%, for malignant ovarian tumors is 25.0–51.0%. The complexity of this situation is asymptomatic tumor in the ovaries and failure to identify a neoplastic process, which is especially important for young women, as well as ease the transition of tumors from one category to another (evolution of the tumor) and the source of the aggressive behavior of the tumor. The purpose of our study was to evaluate the history of concomitant gynecological pathology in a group of patients of reproductive age with ovarian tumors and tumoroid formations, as a predisposing factor for the development of neoplastic process in the ovaries. In our work, we collected and processed complaints and data of obstetric and gynecological anamnesis of 168 patients of reproductive age (18–40 years), operated on the basis of the Department of oncogynecology for tumors and ovarian tumours in the Samara Regional Clinical Oncology Dispensary from 2012 to 2015. We can conclude that since the prognosis of neoplastic process in the ovaries is generally good with timely detection and this disease occurs mainly in women of reproductive age, doctors need to know that when assessing the parity and the presence of gynecological pathology at the moment or in anamnesis, it is not possible to identify alarming risk factors for the development of cancer in the ovaries.

Sign in / Sign up

Export Citation Format

Share Document