scholarly journals Coronary Artery Calcification Score as a Predictor of All-Cause Mortality and Cardiovascular Outcome in Peritoneal Dialysis Patients

2015 ◽  
Vol 36 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Qionghong Xie ◽  
Xiaolin Ge ◽  
Da Shang ◽  
Yun Li ◽  
Huanqing Yan ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Coronary Artery ◽  
Cardiovascular Mortality ◽  
Coronary Artery Calcification ◽  
Cardiovascular Events ◽  
Cox Regression ◽  
Independent Predictor ◽  
Coronary Artery Calcification Score ◽  
Calcification Score ◽  
All Cause Mortality

Background This study aimed to examine whether the coronary artery calcification score (CaCS) was associated with the prognosis of peritoneal dialysis (PD) patients. Methods Adult PD patients who were clinically stable for at least 2 months were recruited for this prospective, observational cohort study. Coronary artery calcification was assessed using multislice spiral computed tomography and was recorded according to the Agatston score. The end-points including all-cause mortality, cardiovascular events, and cardiovascular mortality were assessed. Multivariate Cox regression was used to identify independent predictors of all-cause mortality, cardiovascular events (CVEs), and cardiovascular mortality. Results A total of 179 PD patients (86 men) with a mean age of 63.5 ± 14.8 years were recruited for this study. Coronary artery calcification scores ranging from 0 to 5,257 were stratified as follows: no (CaCS = 0, n = 54), low (0 < CaCS < 400, n = 72), and high (CaCS ≥ 400, n = 53) calcification. The follow-up duration was 30.6 ± 16.2 (24 – 63) months. Compared with the no calcification group, patients with a higher CaCS were older and had lower diastolic blood pressure, residual renal function, and serum albumin, and higher HbA1C and serum insulin. Multivariate Cox regression revealed that the CaCS was an independent predictor for all the 3 endpoints after adjustment in PD patients. Conclusions CaCS was an independent predictor of all-cause mortality, cardiovascular events, and cardiovascular mortality in patients receiving peritoneal dialysis.

scholarly journals Association of Ambulatory Blood Pressure with All-Cause Mortality and Cardiovascular Outcomes in Peritoneal Dialysis Patients

2020 ◽  
Vol 45 (6) ◽  
pp. 890-899
Author(s):  
Shuqi Dai ◽  
Yun Chen ◽  
Da Shang ◽  
Xiaolin Ge ◽  
Qionghong Xie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peritoneal Dialysis ◽  
Clinical Outcomes ◽  
Ambulatory Blood Pressure ◽  
Cardiovascular Mortality ◽  
Cardiovascular Events ◽  
Independent Predictor ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring ◽  
All Cause Mortality

<b><i>Background:</i></b> Ambulatory blood pressure monitoring is the gold standard for the diagnosis of hypertension, but its effects on all-cause mortality and cardiovascular outcomes in peritoneal dialysis (PD) patients remain uncertain. We aimed to investigate the association between ambulatory blood pressure and clinical outcomes in PD patients. <b><i>Methods:</i></b> A prospective, observational cohort study was conducted in PD patients enrolled from March 2001 to July 2018 and followed until October 2019. Blood pressure was evaluated using 24-h ambulatory blood pressure monitoring. The endpoints included all-cause mortality, cardiovascular mortality, and cardiovascular events. Multivariable Cox regression was used to identify the associations between ambulatory blood pressure and endpoints. Subsequently, multivariable logistic regression was conducted to identify factors associated with elevated pulse pressure (PP). <b><i>Results:</i></b> A total of 260 PD patients (154 men, 59.2%) were recruited. The median follow-up duration was 40.7 months. Our studies revealed that PP was an independent predictor of all-cause mortality (hazard ratio [HR], 1.018; 95% CI, 1.001–1.034; <i>p</i> = 0.032), cardiovascular mortality (HR, 1.039; 95% CI, 1.017–1.061; <i>p</i> &#x3c; 0.001), and cardiovascular events (HR, 1.028; 95% CI, 1.011–1.046; <i>p</i> = 0.001). Systolic blood pressure was an independent predictor of cardiovascular mortality (HR, 1.023; 95% CI, 1.007–1.040; <i>p</i> = 0.005) and cardiovascular events (HR, 1.018; 95% CI, 1.006–1.030; <i>p</i> = 0.003). Vascular calcification was significantly associated with elevated PP (OR, 3.069; 95% CI, 1.632–5.772; <i>p</i> = 0.001). <b><i>Conclusion:</i></b> 24-h ambulatory PP was the most significant predictor of all blood pressure indicators for clinical outcomes in PD patients.

Predictive Value of Osteoprotegerin for Detecting Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients in Correlation with Extent of Calcification Detected by Multidetector Computed Tomography

2019 ◽  
Vol 19 (6) ◽  
pp. 845-851 ◽  
Author(s):  
Sahar Ahmed ◽  
Rasha Sobh
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Coronary Artery Calcification Score ◽  
Type 2 Diabetic Patients ◽  
Duration Of Diabetes ◽  
Calcification Score ◽  
Type 2 Diabetic

Background:Osteoprotegerin (OPG) is a tumor necrosis factor receptor super-family member. It specifically acts on bone by increasing bone mineral density and bone volume. Recent studies have evidenced its close relation to the development of atherosclerosis and plaque destabilization. Elevated OPG level has also been associated with the degree of coronary calcification in the general population and it has been considered to be a marker of coronary atherosclerosis.Objective:The aim of this study was to determine the relation between OPG levels and Coronary Artery Calcification score (CACs) in Type 2 diabetic patients in comparison to healthy controls.Methods:Our study included 45 type 2 diabetic patients (mean age 51.7 years; 51.1% male) without evidence of previous CVD and 45 healthy age and sex matched subjects as control. All participants were subjected to full history, full examination and lab investigations. Serum OPG concentration was measured by an enzyme-linked immunosorbent assay (ELISA) and CAC imaging was performed using non contrast Multi detector CT of the heart.Results:Significant CAC (<10 Agatston units) was seen in 23 patients (51.11 %).:OPG was significantly high in diabetic patients in comparison to controls with mean 12.9±5.7 pmol/l in cases, and 8.6±0.5 pmol/l in controls (P value < 0.001).:The Coronary Artery Calcification Score (CACS) was positively correlated with age and duration of diabetes. The OPG was positively correlated with age, fasting blood sugar and duration of diabetes. The CACS showed a significantly positive correlation with OPG.Conclusion:Findings suggested that increasing in serum OPG was consistent with CAC and could be used for the early diagnosis of subclinical atherosclerosis.

The role of Coronary Artery Calcification Score in lung cancer patients

2021 ◽  
pp. 110140
Author(s):  
Valerio Nardone ◽  
Alfonso Reginelli ◽  
Giuseppina De Marco ◽  
Teresa Di Pietro ◽  
Roberta Grassi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Coronary Artery ◽  
Cancer Patients ◽  
Coronary Artery Calcification ◽  
Coronary Artery Calcification Score ◽  
Lung Cancer Patients ◽  
Calcification Score

Poster 17 Spinal Cord Injury Increases Risk for Coronary Artery Disease as Determined by Coronary Artery Calcification Score

PM&R ◽  
2015 ◽  
Vol 7 ◽  
pp. S97-S97
Author(s):  
Cristin McKenna ◽  
Christopher Cirnigliaro ◽  
Michael LaFountaine ◽  
Kristen Swonger ◽  
Steven Kirshblum ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Artery Calcification Score ◽  
Calcification Score ◽  
Cord Injury ◽  
Artery Disease

Abstract 6023: The Need for Blood Transfusion Is an Independent Predictor of Incident Cardiovascular Events and All-Cause Mortality among Patients Undergoing Percutaneous Coronary Intervention

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Jasper Jan Brugts ◽  
Nestor Mercado ◽  
Joachim Ix ◽  
Michael G Shlipak ◽  
Simon R Dixon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Transfusion ◽  
Cardiovascular Events ◽  
Cox Regression ◽  
Independent Predictor ◽  
P Value ◽  
Transfusion Rate ◽  
Cox Regression Analysis ◽  
Increased Risk ◽  
All Cause Mortality

Periprocedural bleeding is one of the most frequent complications of percutaneours coronary interventions. We assessed the relation between blood transfusion and all-cause mortality or incident cardiovascular events (death, MI, stroke) among 6103 patients of the Evaluation of Oral Xemilofiban in Controlling Thrombotic Events (EXCITE)-trial. Subjects were followed for 7 months after enrollment for the occurrence of events. Multivariate Cox-regression analysis evaluated the independent association of blood transfusion with each outcome adjusted for age, gender, race, diabetes mellitus, hypertension, hypercholesterolemia, history of MI, PCI, CABG, heart failure, LVEF<30%, use of beta-blockers, statins, ACE-inhibitors, platelet inhibitors and allocation to treatment with xemolifiban. In addition, propensity score analyses were performed (ROC 0.80). Mean age was 59.2 years, 21.7% were female, and 18.9% had diabetes mellitus. Of the169 patients who received blood transfusion, 14 (8.3%) died and 42 (24.9%) experienced a CVD event. Of the 5934 patients without transfusion, 65 (1.1%) died (p-value: <0.001) and 555 (9,4%) experienced a CVD event (p-value: <0.001) In multivariate analysis, blood transfusion was associated with a 5.3 fold increased risk of mortality (HR 5.3; 95% CI 2.8 –10.2), and a 2.5 fold increased risk of incident CVD (HR 2.5; 95% CI 1.7–3.4.) Noteworthy, patients who were US citizens had a higher transfusion rate then non-US citizens (OR 1.45, 95%CI 1.02–2.06) The need of blood transfusion is a strong and independent predictor of all-cause mortality and incident CVD events among patients undergoing PCI.

Sign in / Sign up

Export Citation Format

Share Document