Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm

Combined measurements of meltwater discharge from the portal and of water level in a borehole drilled to the bed of Findelengletscher, Switzerland, were obtained during the later part of the 1993 ablation season. A severe storm, lasting from 22 through 24 September, produced at least 130 mm of precipitation over the glacier, largely as rain. The combined hydrological records indicate periods during which the basal drainage system became constricted and water storage in the glacier increased, as well as phases of channel growth. During the storm, water pressure generally increased as water backed up in the drainage network. Abrupt, temporary falls in borehole water level were accompanied by pulses in portal discharge. On 24 September, whilst borehole water level continued to rise, water started to escape under pressure with a resultant increase in discharge. As the drainage network expanded, a large amount of debris was flushed from a wide area of the bed. Progressive growth in channel capacity as discharge increased enabled stored water to drain and borehole water level to fall rapidly. Possible relationships between observed borehole water levels and water pressures in subglacial channels are influenced by hydraulic conditions at the base of the hole, distance between the hole and a channel, and the nature of the substrate.

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Sustainable Regional Economic Development: Analysis and Management Methods

Economics and Management ◽

10.35854/1998-1627-2020-1-23-34 ◽

2020 ◽

Vol 26 (1) ◽

pp. 23-34

Author(s):

B. M. Grinchel’ ◽

E. A. Nazarova

Keyword(s):

Economic Development ◽

Mathematical Treatment ◽

Mathematical Tool ◽

Russian Regions ◽

Regional Economic ◽

Management Scheme ◽

Progressive Growth ◽

Sustainable Regional Development ◽

High Level ◽

Development Analysis

The presented study examines methods for analyzing and managing sustainable economic development of Russian regions and possible criteria for assessing and improving sustainability.Aim. The study aims to provide a theoretical and empirical justification for the use of regional competitive attractiveness assessment to manage economic development and improve its sustainability.Tasks. Based on the measurement and analysis of economic competitive attractiveness indicators and their mathematical treatment, the authors assess the sustainability of development of Russian regions in 2013–2017 and the causes of deviations from progressive growth.Methods. This study proposes a mathematical tool for measuring the sustainability of Russian regions by assessing their competitive attractiveness and develops a typology of sustainability in the mathematical space of two variables.Results. Methods for analyzing and managing the sustainability of economic development of Russian regions under the influence of political and economic challenges and risks are proposed. The level and dynamics of regional competitive attractiveness are taken as a criterion of sustainability of economic development. The authors provide methods and indicators for assessing economic competitive attractiveness and criteria for measuring the sustainability of development, which allow them to draw conclusions about the reaction of different regions to the challenges and risks of development in 2013–2017. The study proposes a management scheme for sustainable regional development with a focus on the comprehensive improvement of regional economic competitive attractiveness and potential ways to improve it, including training of municipal and regional managers in crisis management associated with economic and political challenges and risks.Conclusions. Based on the proposed criterion of economic development sustainability and assessment of the competitive attractiveness of regions and their rankings, it is shown that in 2013–2017 45 out of 83 regions were developing sustainably; by 2017, 19 regions out of the 32 that suffered losses in the competitive attractiveness level and rankings in 2015–2016 have managed to restore the sustainability of economic development and their rankings. This study proves that regions with a high level of economic competitive attractiveness show increased sustainability of development.

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Analysis of age distribution of advanced colorectal neoplasm in average-risk Chinese

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2012.00368 ◽

2013 ◽

Vol 32 (4) ◽

pp. 368-373

Author(s):

Rong LIANG ◽

En-da YU ◽

Wei ZHU ◽

Jie GAO ◽

Zhao-shen LI ◽

...

Keyword(s):

Colorectal Neoplasm ◽

Age Distribution ◽

Average Risk

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Visceral obesity as a risk factor for colorectal neoplasm

Journal of Gastroenterology and Hepatology ◽

10.1111/j.1440-1746.2007.05125.x ◽

2008 ◽

Vol 23 (3) ◽

pp. 411-417 ◽

Cited By ~ 55

Author(s):

Tae-Hoon Oh ◽

Jeong-Sik Byeon ◽

Seung-Jae Myung ◽

Suk-Kyun Yang ◽

Kwi-Sook Choi ◽

...

Keyword(s):

Risk Factor ◽

Colorectal Neoplasm ◽

Visceral Obesity

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Immunohistochemical Characterization of Canine Transmissible Venereal Tumor

Veterinary Pathology ◽

10.1177/030098589603300301 ◽

1996 ◽

Vol 33 (3) ◽

pp. 257-263 ◽

Cited By ~ 64

Author(s):

E. Mozos ◽

A. Méndez ◽

J. C. Gómez-Villamandos ◽

J. Martín de las Mulas ◽

J. Pérez

Keyword(s):

Light Chain ◽

B Lymphocyte ◽

Protein S ◽

Lambda Light Chain ◽

Formalin Fixed Paraffin ◽

S 100 ◽

Formalin Fixed Paraffin Embedded ◽

Progressive Growth ◽

Staining Techniques ◽

Alpha 1 Antitrypsin

The collective immunohistochemical expression of human lysozyme, human alpha-1-antitrypsin, human CD3 antigen, calf vimentin, human keratins, human lambda light chains, canine immunoglobulins IgG, IgM, and bovine protein S-100 has been analyzed on formalin-fixed, paraffin-embedded tissue sections of 25 spontaneous canine transmissible venereal tumors (CTVT) from both genital and extragenital locations using the avidin-biotin-peroxidase complex technique. Lysozyme immunoreactivity was detected in 10/25 CTVT, alpha-1-antitrypsin in 14/25 CTVT, and vimentin in 25/25 CTVT. All CTVT cells were negative to keratins 5 + 8 of the Moll catalogue (RCK-102), S-100 protein, lambda light-chain immunoglobulins, IgG, IgM, and CD3 antigen. The intratumoral T- and B-lymphocyte infiltrate was differentiated using CD3 antigen, lambda light-chain immunoglobulins, IgG, and IgM, and this technique could be useful to evaluate the regressive or progressive growth stage of venereal tumors. Our findings support the hypothesis of a histiocytic immunophenotype for CTVT, and these staining techniques could be used in the differential diagnosis with lymphomas.

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T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites.

Journal of Experimental Medicine ◽

10.1084/jem.145.2.275 ◽

1977 ◽

Vol 145 (2) ◽

pp. 275-292 ◽

Cited By ~ 54

Author(s):

R J North ◽

D P Kirstein

Keyword(s):

T Cell ◽

Cell Mediated Immunity ◽

Microbial Infection ◽

Nonspecific Resistance ◽

Normal Test ◽

Concomitant Immunity ◽

Progressive Growth ◽

Concomitant Resistance ◽

Growth Of Tumor ◽

Syngeneic Tumors

Progressive growth of the SA1 sarcoma was shown to result in the generation of a state of concomitant resistance to growth of a second implant of the same tumor. The responding lymph nodes of concomitantly immune mice were shown to contain theta-positive T cells that could specifically neutralize the growth of tumor cells in a normal test recipient. Nevertheless, the concomitantly immune host itself was capable to a limited extent of suppressing the growth of unrelated tumors. The generation of immunity, moreover, was associated with the generation of a powerful state of macrophage-mediated, nonspecific resistance to the bacterial parasite, Listeria monocytogenes. It was concluded that systemic macrophage activation was the consequence of the generation of T-cell-mediated immunity to the progressively growing tumor, and that this not only gave the host the capacity to inhibit the growth of unrelated tumors, but also to protect itself against microbial infection. The results gives credence to the view that macrophages play a central role in defense against microbial and neoplastic growth.

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Mapping the Functional Assessment of Cancer Therapy-General or -Colorectal to SF-6D in Chinese Patients with Colorectal Neoplasm

Value in Health ◽

10.1016/j.jval.2011.12.009 ◽

2012 ◽

Vol 15 (3) ◽

pp. 495-503 ◽

Cited By ~ 23

Author(s):

Carlos K.H. Wong ◽

Cindy L.K. Lam ◽

Donna Rowen ◽

Sarah M. McGhee ◽

Ka-Ping Ma ◽

...

Keyword(s):

Cancer Therapy ◽

Functional Assessment ◽

Colorectal Neoplasm ◽

Chinese Patients

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Cellular and Chemical Events During Enamel Maturation

Critical Reviews in Oral Biology & Medicine ◽

10.1177/10454411980090020101 ◽

1998 ◽

Vol 9 (2) ◽

pp. 128-161 ◽

Cited By ~ 489

Author(s):

C.E. Smith

Keyword(s):

Crystal Growth ◽

Driving Forces ◽

Morphological Changes ◽

Matrix Proteins ◽

Secretory Product ◽

Water Matrix ◽

Mineralized Tissues ◽

Progressive Growth ◽

Chemical Events ◽

Protein Rich

This review focuses on the process of enamel maturation, a series of events associated with slow, progressive growth in the width and thickness of apatitic crystals. This developmental step causes gradual physical hardening and transformation of soft, newly formed enamel into one of the most durable mineralized tissues produced biologically. Enamel is the secretory product of specialized epithelial cells, the ameloblasts, which make this covering on the crowns of teeth in two steps. First, they roughly "map out" the location and limits (overall thickness) of the entire extracellular layer as a protein-rich, acellular, and avascular matrix filled with thin, ribbon-like crystals of carbonated hydroxyapatite. These initial crystals are organized spatially into rod and interrod territories as they form, and rod crystals are lengthened by Tomes' processes in tandem with appositional movement of ameloblasts away from the dentin surface. Once the full thickness of enamel has been formed, ameloblasts initiate a series of repetitive morphological changes at the enamel surface in which tight junctions and deep membrane infoldings periodically appear (ruffle-ended), then disappear for short intervals (smooth-ended), from the apical ends of the cells. As this happens, the enamel covered by these cells changes rhythmically in net pH from mildly acidic (ruffle-ended) to near-physiologic (smooth-ended) as mineral crystals slowly expand into the "spaces" (volume) formerly occupied by matrix proteins and water. Matrix proteins are processed and degraded by proteinases throughout amelogenesis, but they undergo more rapid destruction once ameloblast modulation begins. Ruffle-ended ameloblasts appear to function primarily as a regulatory and transport epithelium for controlling the movement of calcium and other ions such as bicarbonate into enamel to maintain buffering capacity and driving forces optimized for surface crystal growth. The reason ruffle-ended ameloblasts become smooth-ended periodically is unknown, although this event seems to be crucial for sustaining long-term crystal growth.

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