scholarly journals New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism

2020 ◽  
Vol 26 (40) ◽  
pp. 6224-6240
Author(s):  
Xian-Wan Jiang ◽  
Ya-Ting Li ◽  
Jian-Zhong Ye ◽  
Long-Xian Lv ◽  
Li-Ya Yang ◽  
...  
2020 ◽  
Vol 75 ◽  
pp. 104278
Author(s):  
Fengfeng Mei ◽  
Zhouwei Duan ◽  
Muxue Chen ◽  
Jinfeng Lu ◽  
Meihui Zhao ◽  
...  

2020 ◽  
Vol 11 (9) ◽  
pp. 8369-8379
Author(s):  
Wei Xu ◽  
Ling Lin ◽  
An Liu ◽  
Tuo Zhang ◽  
Sheng Zhang ◽  
...  

LTA regulates SCFA metabolism and improves intestinal mucosal immunity by improving cholesterol synthesis in the liver and inhibiting gluconeogenesis in the colon.


1967 ◽  
Vol 70 (1) ◽  
pp. 8-15 ◽  
Author(s):  
J.B. Sidbury ◽  
Elizabeth K. Smith ◽  
William Harlan

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Catharina M. C. Mels ◽  
Peet Jansen van Rensburg ◽  
Francois H. van der Westhuizen ◽  
Pieter J. Pretorius ◽  
Elardus Erasmus

Acetylsalicylic acid and/or its metabolites are implicated to have various effects on metabolism and, especially, on mitochondrial function. These effects include both inhibitory and stimulatory effects. We investigated the effect of both combined and separate oral acetylsalicylic acid and acetaminophen administration at therapeutic doses on the urinary metabolite profile of human subjects. In this paper, we provided in vivo evidence, in human subjects, of a statistically significant increase in isobutyrylcarnitine after the administration of a therapeutic dose of acetylsalicylic acid. We, therefore, propose an inhibitory effect of acetylsalicylic acid on the short-chain fatty acid metabolism, possibly at the level of isobutyryl-CoA dehydrogenase.


PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166161 ◽  
Author(s):  
Evelien P. J. G. Neis ◽  
Johanne G. Bloemen ◽  
Sander S. Rensen ◽  
Joost R. van der Vorst ◽  
Maartje A. van den Broek ◽  
...  

2017 ◽  
Vol 66 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Izabela Sitkiewicz ◽  
James M. Musser

Group A Streptococcus (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression analyses have yielded extensive new information regarding the regulation of genes encoding known and putative virulence factors in GAS. A microarray analysis found that transcription of the GAS gene M5005_Spy_1343 was significantly increased in response to interaction with human polymorphonuclear leukocytes. M5005_Spy_1343 is predicted to encode a member of the LysR family of transcriptional regulators and is located upstream of a putative operon containing six genes. Five of these genes have sequence similarity to genes involved in short-chain fatty acid metabolism, whereas the sixth gene (luxS) is found in many bacterial species and is involved in quorum sensing. Unexpectedly, inactivation of the M5005_Spy_1343 gene resulted in hypervirulence in an intraperitoneal mouse model of infection. Increased virulence was not due to changes in luxS gene expression. We postulate that short-chain fatty acid metabolism is involved in GAS pathogenesis.


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