scholarly journals Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats

2003 ◽  
Vol 9 (12) ◽  
pp. 2742 ◽  
Author(s):  
Tao-Tao Liu
1975 ◽  
Vol 53 (4) ◽  
pp. 433-437 ◽  
Author(s):  
J. U. Bell ◽  
D. J. Ecobichon

The development of the apparent kinetic parameters Km and Vmax was studied in perinatal Wistar rats for three functionally diverse, hepatic enzymes (p-nitroanisole O-demethylase, carboxylesterase and bromosulphophthalein–glutathione conjugating enzyme), the period studied being from 3 days prepartum to 35 days postpartum. The kinetic parameters underwent marked quantitative changes during development, which appeared to be independent of sex for the first 5 weeks postpartum.


1998 ◽  
Vol 95 ◽  
pp. 195-196
Author(s):  
C. Lerche-Langrand ◽  
V. Moronvalle-Halley ◽  
J.P. Sarsat ◽  
V. Létang ◽  
D. Leroy ◽  
...  

2008 ◽  
Vol 172 (3) ◽  
pp. 224-234 ◽  
Author(s):  
Periasamy Srinivasan ◽  
Subramaniyan Suchalatha ◽  
Pon Velayutham Anandh Babu ◽  
Rethinam Sundaresan Devi ◽  
Shoba Narayan ◽  
...  

2017 ◽  
Vol 108 ◽  
pp. 194-202 ◽  
Author(s):  
Jae Kyeom Kim ◽  
Noemia Strapazzon ◽  
Cynthia M. Gallaher ◽  
Dwight R. Stoll ◽  
William Thomas ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Le Lv ◽  
Chenshu Xu ◽  
Xiaoye Mo ◽  
Hai-Yan Sun ◽  
Huichang Bi

Green tea polyphenols (GTPs) have been shown to exhibit diverse beneficial effects against a variety of diseases. Acetaminophen (APAP) overdose is one of the most frequent causes of drug-induced liver injury. In the current study, we aimed to investigate the protective effect of GTP on APAP-induced liver injury in mice and the underlying mechanisms involved. Male C57BL/6J mice were treated orally with different doses of GTP (37.5, 75, or 150 mg/kg) 4 h after APAP overdose (400 mg/kg) and continuously given every 8 h until sacrificed at 4, 12, 20, and 48 h after the first treatment of GTP. Survival rate and histological and biochemical assessments were performed to evaluate the APAP-induced liver injury. Protein expression of multiple drug metabolizing enzymes and transporters was measured to demonstrate the possible mechanisms involved. Our results revealed that administration of different doses of GTP significantly alleviated APAP-induced liver injury by improving the survival rate, hepatocellular necrosis, and ALT/AST/GSH levels after APAP overdose (400 mg/kg). The protein expression of APAP-induced drug transporters and metabolizing enzymes was mostly induced by GTP treatment, which was followed by reduction in drug transporters at the later time points. The current study collectively demonstrated that GTP protects against APAP-induced liver injury, possibly through regulating drug metabolizing enzymes and transporters after APAP overdose.


1994 ◽  
Vol 22 (2) ◽  
pp. 124S-124S ◽  
Author(s):  
MAY AKRAWI ◽  
VERA ROGIERS ◽  
ANTOINNE VERCRUYSSE ◽  
IAN R. PHILLIPS ◽  
ELIZABETH A. SHEPHARD

2001 ◽  
Vol 53 (4) ◽  
pp. 569-577 ◽  
Author(s):  
Pius P. Maliakal ◽  
Peter F. Coville ◽  
Sompon Wanwimolruk

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