scholarly journals DNA polymerase ζ: new insight into eukaryotic mutagenesis and mammalian embryonic development

2003 ◽  
Vol 9 (6) ◽  
pp. 1165 ◽  
Author(s):  
Feng Zhu
Keyword(s):  
Embryonic Development ◽  
Dna Polymerase ◽  
Mammalian Embryonic Development ◽  
Insight Into

scholarly journals Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation

2006 ◽  
Vol 26 (23) ◽  
pp. 8880-8891 ◽  
Author(s):  
Linda Panić ◽  
Sanda Tamarut ◽  
Melanie Sticker-Jantscheff ◽  
Martina Barkić ◽  
Davor Solter ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Embryonic Development ◽  
Ribosomal Protein ◽  
Ribosome Biogenesis ◽  
Fetal Liver ◽  
Genetic Inactivation ◽  
Developmental Program ◽  
Ribosomal Protein S6 ◽  
M Phase ◽  
Insight Into

ABSTRACT Nascent ribosome biogenesis is required during cell growth. To gain insight into the importance of this process during mouse oogenesis and embryonic development, we deleted one allele of the ribosomal protein S6 gene in growing oocytes and generated S6-heterozygous embryos. Oogenesis and embryonic development until embryonic day 5.5 (E5.5) were normal. However, inhibition of entry into M phase of the cell cycle and apoptosis became evident post-E5.5 and led to perigastrulation lethality. Genetic inactivation of p53 bypassed this checkpoint and prolonged development until E12.5, when the embryos died, showing decreased expression of D-type cyclins, diminished fetal liver erythropoiesis, and placental defects. Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program.

scholarly journals A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5847
Author(s):  
Satheesh Gujarathi ◽  
Maroof Khan Zafar ◽  
Xingui Liu ◽  
Robert L. Eoff ◽  
Guangrong Zheng
Keyword(s):  
Natural Product ◽  
Dna Polymerase ◽  
Activity Relationship ◽  
Synthetic Method ◽  
Valuable Insight ◽  
Dna Polymerase Β ◽  
Sar Studies ◽  
Human Dna ◽  
Structure Activity ◽  
Insight Into

Garcinoic acid has been identified as an inhibitor of DNA polymerase β (pol β). However, no structure-activity relationship (SAR) studies of garcinoic acid as a pol β inhibitor have been conducted, in part due to the lack of an efficient synthetic method for this natural product and its analogs. We developed an efficient semi-synthetic method for garcinoic acid and its analogs by starting from natural product δ-tocotrienol. Our preliminary SAR studies provided a valuable insight into future discovery of garcinoic acid-based pol β inhibitors.

scholarly journals Features of DNA Repair in the Early Stages of Mammalian Embryonic Development

Genes ◽  
2020 ◽  
Vol 11 (10) ◽  
pp. 1138 ◽  
Author(s):  
Evgenia V. Khokhlova ◽  
Zoia S. Fesenko ◽  
Julia V. Sopova ◽  
Elena I. Leonova
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Embryonic Development ◽  
Somatic Cells ◽  
Genomic Integrity ◽  
Embryonic Period ◽  
Early Stages ◽  
Mammalian Embryos ◽  
Disparate Data ◽  
Mammalian Embryonic Development

Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to dysfunction in certain tissues or organs, while a violation of genomic integrity during the embryonic period often leads to death. A mammalian embryo’s ability to respond to damaged DNA and repair it, as well as its sensitivity to specific lesions, is still not well understood. In this review, we combine disparate data on repair processes in the early stages of preimplantation development in mammalian embryos.

The Role of Autophagy in Early Mammalian Embryonic Development

2013 ◽  
Vol 30 (3) ◽  
pp. 86-94 ◽  
Author(s):  
Satoshi Tsukamoto ◽  
Atsushi Yamamoto
Keyword(s):  
Embryonic Development ◽  
Mammalian Embryonic Development

Mechanics of Embryonic Head Fold Morphogenesis

2008 ◽  
Author(s):  
Victor D. Varner ◽  
Dmitry A. Voronov ◽  
Larry A. Taber
Keyword(s):  
Embryonic Development ◽  
Incubation Period ◽  
Neural Plate ◽  
Vitelline Membrane ◽  
Heart Tube ◽  
Germ Layers ◽  
Embryonic Tissues ◽  
Anterior Extent ◽  
Insight Into ◽  
Embryonic Head

Head fold morphogenesis constitutes the first discernible epithelial folding event in the embryonic development of the chick. It arises at Hamburger and Hamilton (HH) stage 6 (approximately 24 hours into a 21-day incubation period) and establishes the anterior extent of the embryo [1]. At this stage, the embryonic blastoderm is composed of three germ layers (endoderm, mesoderm, and ectoderm), which are organized into a flat layered sheet that overlies the fibrous vitelline membrane (VM). Within this blastodermal sheet, a crescent-shaped head fold develops just anterior to the elongating notochord, spanning across the embryonic midline at the rostral end of neural plate. At the crest of this fold, the bilateral precardiac plates fuse in a cranial to caudal direction and give rise to the primitive heart tube and foregut [2, 3]. An understanding of head fold morphogenesis may thus offer insight into how embryonic tissues are arranged to make ready for proper cardiac formation.

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