scholarly journals A simple effective method for frailty in Heart Failure with impact on clinical outcomes in north Indian population

2021 ◽  
Vol 33 (3) ◽  
pp. 213-220
Author(s):  
Gurbhej Singh ◽  
Rohit Tandon ◽  
Neelesh C Pandey ◽  
Namita Bansal ◽  
Abhishek Goyal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcomes ◽  
Indian Population ◽  
North Indian Population

scholarly journals MUTATIONAL ANALYSIS OF MYBPC3 GENE IN DILATED CARDIOMYOPATHY PATIENTS IN NORTH INDIAN POPULATION

2018 ◽  
Vol 26 (1) ◽  
Author(s):  
Rubi Bhola ◽  
Om Shankar ◽  
Rashmi Gupta ◽  
Preeti Kumari ◽  
Royana Singh
Keyword(s):  
Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Indian Population ◽  
Clinical Medicine ◽  
Mutational Analysis ◽  
Cardiac Contraction ◽  
North Indian Population ◽  
Coding Region ◽  
Salting Out ◽  
Mybpc3 Gene

Introduction: Today, molecular cardiology is characterized by the integration of high-technology laboratory studies and clinical medicine. Molecular genetics has redefined the etiology and diagnostic criteria for numerous diseases and has led to the development of new, individualized treatment regimens for several cardiovascular diseases. Amongst all, dilated cardiomyopathy is the commonest cause of heart failure. This study was conducted to identify the possible genetic change in dilated cardiomyopathy in North Indian population. Material & Methods: Blood samples of dilated cardiomyopathy patients were collected from Cardiology OPD, Sir Sunderlal Hospital, Banaras Hindu University. DNA was isolated using salting out method. PCR was done to amplify exons 32, 33 and 34 of MYBPC3 gene. The PCR product was sequenced to detect the mutational changes in Exons 32-34 of MYBPC 3 gene. Results: There were 65 control samples and 65 DCM samples were collected. Total 76 intronic variations were reported. In three (BHU/15/425, BHU/15/450, BHU/16/89) patients, disease causing pathogenic variant c3624_3625insC (rs397516029, HMGD CD0910628) was reported in MYBPC3 gene. Insertion of G at 47354119_47354120 position was reported that lead to a frameshift mutation in three subjects. Several Missence variants were also reported 47354121G>C, 47353899C>T, 47353715C>A, 47353647A>C, 47353626G>T that are present in coding region and may lead to alteration in protein structure and function. Conclusion: Evidence from previous study reported that MYBPC3 play important role in cardiac contraction and responsible for pathogenesis of dilated cardiomyopathy. Therefore, the identification of frequent genetic transmission of dilated cardiomyopathy provides an important tool for the study of pathogenesis of this disease, which is a frequent cause of admission to the hospital and of heart failure

scholarly journals IMPACT OF HEALTH LITERACY ON KNOWLEDGE, SELF-CARE AND CLINICAL OUTCOMES IN HEART FAILURE PATIENTS

2018 ◽  
Vol 34 (10) ◽  
pp. S93
Author(s):  
J. McConnery ◽  
F. Foroutan ◽  
A. Alba ◽  
H. Ross ◽  
J. MacIver
Keyword(s):  
Heart Failure ◽  
Health Literacy ◽  
Clinical Outcomes ◽  
Self Care ◽  
Heart Failure Patients
Sign in / Sign up

Export Citation Format

Share Document