Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery
2014 ◽
Vol 10
◽
pp. 2903-2911
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Keyword(s):
Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole–HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.
2013 ◽
Vol 110
(6)
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pp. 1654-1662
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Keyword(s):
2013 ◽
Vol 176
◽
pp. 1176-1182
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Keyword(s):
2011 ◽
Vol 51
(10)
◽
pp. 2024-2034
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2011 ◽
Vol 13
(11)
◽
pp. 1209-1212
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Keyword(s):
Acrylamide inverse miniemulsion polymerization: in situ, real-time monitoring using nir spectroscopy
2014 ◽
Vol 31
(4)
◽
pp. 925-933
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Keyword(s):