scholarly journals Cyclodextrin–polysaccharide-based, in situ-gelled system for ocular antifungal delivery

2014 ◽  
Vol 10 ◽  
pp. 2903-2911 ◽  
Author(s):  
Anxo Fernández-Ferreiro ◽  
Noelia Fernández Bargiela ◽  
María Santiago Varela ◽  
Maria Gil Martínez ◽  
Maria Pardo ◽  
...  

Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole–HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.

2013 ◽  
Vol 176 ◽  
pp. 1176-1182 ◽  
Author(s):  
Yuki Aonuma ◽  
Yasuhiko Kondo ◽  
Ayumi Hirano-Iwata ◽  
Atena Nishikawa ◽  
Yasuo Shinohara ◽  
...  

2018 ◽  
Vol 2 (4) ◽  
pp. 1-4 ◽  
Author(s):  
Marios Sophocleous ◽  
Pericles Savva ◽  
Michael F. Petrou ◽  
John K. Atkinson ◽  
Julius Georgiou

2014 ◽  
Vol 31 (4) ◽  
pp. 925-933 ◽  
Author(s):  
M. M. E. Colmán ◽  
D. L. Chicoma ◽  
R. Giudici ◽  
P. H. H. Araújo ◽  
C. Sayer

2014 ◽  
Vol 87 (1) ◽  
pp. 372-375 ◽  
Author(s):  
Renaud Boisseau ◽  
Ugo Bussy ◽  
Patrick Giraudeau ◽  
Mohammed Boujtita

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