scholarly journals Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8–DMSO: application to the synthesis of vernakalant

2015 ◽  
Vol 11 ◽  
pp. 1008-1016 ◽  
Author(s):  
Dnyaneshwar N Garad ◽  
Subhash D Tanpure ◽  
Santosh B Mhaske
Keyword(s):  
Dimethyl Sulfoxide ◽  
Ammonium Persulfate ◽  
Primary Amines ◽  
Radical Mechanism ◽  
Forming Process ◽  
One Pot ◽  
Practical Synthesis ◽  
Cyclic Imides ◽  
Cyclic Anhydrides ◽  
High Yields

Ammonium persulfate–dimethyl sulfoxide (APS–DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.

scholarly journals Synthesis of Bis-2,3-dihydroquinazolin-4(1H)-ones and 2,3-Dihydroquinazolin-4(1H)-ones Derivatives with the Aid of Silica-Supported Preyssler Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Ali Gharib ◽  
Bibi Robabeh Hashemipour Khorasani ◽  
Manouchehr Jahangir ◽  
Mina Roshani ◽  
Reza Safaee
Keyword(s):  
Primary Amine ◽  
Ammonium Carbonate ◽  
Aromatic Aldehydes ◽  
Product Yield ◽  
Primary Amines ◽  
Isatoic Anhydride ◽  
One Pot ◽  
High Yields ◽  
First Time

One-pot three-component condensation of isatoic anhydride with primary amines or ammonium carbonate and aromatic aldehydes in refluxing ethanol in the presence of catalytic amounts of silica-supported preyssler nanoparticles (SPNP) afforded the corresponding 2,3-dihydroquinazolin-4(1H)-ones in high yields, and bis-dihydroquinazolinones were synthesized for the first time by a novel pseudo-five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. The catalyst is reusable and can be applied several times without any decrease in product yield.

scholarly journals One-Pot Synthesis of Tetrasubstituted Imidazoles Catalyzed by Preyssler-Type Heteropoly Acid

2011 ◽  
Vol 8 (2) ◽  
pp. 547-552 ◽  
Author(s):  
Ali Javid ◽  
Majid M. Heravi ◽  
F. F. Bamoharram ◽  
Mohsen Nikpour
Keyword(s):  
Heteropoly Acid ◽  
Ammonium Acetate ◽  
Reaction Times ◽  
Acid Catalyst ◽  
Aromatic Aldehydes ◽  
Primary Amines ◽  
One Pot ◽  
High Yields ◽  
Work Up ◽  
Tetrasubstituted Imidazoles

A simple one-pot four-component synthetic method was reported for the preparation of tetrasubstituted imidazole derivatives from benzil, aromatic aldehydes, primary amines and ammonium acetate in the presence of Preyssler-type heteropoly acid catalyst. This method was proved to be eco-benign, easy work-up, convenient, relatively short reaction times and the products were isolated with high yields.

T3P® – A Benign Desulfurating Reagent in the Synthesis of Isothiocyanates

Synthesis ◽  
2017 ◽  
Vol 50 (05) ◽  
pp. 1141-1151 ◽  
Author(s):  
Tadeusz Gajda ◽  
Łukasz Janczewski ◽  
Anna Gajda ◽  
Sebastian Frankowski ◽  
Tomasz Goszczyński
Keyword(s):  
Carbon Disulfide ◽  
Phosphonic Acid ◽  
Acid Anhydride ◽  
Primary Amines ◽  
One Pot ◽  
Alkyl Aryl ◽  
High Yields

A number of alkyl, aryl and bifunctional isothiocyanates are obtained in moderate to high yields (41–94%) in a two-step, one-pot reaction of the parent primary amines or their salts with carbon disulfide, followed by reaction of the thus formed dithiocarbamates with T3P® (propane phosphonic acid anhydride) as a new and efficient desulfurating agent.

Solvent-free synthesis of functionalised indenothiazoles using four-component reactions of ninhydrin

2017 ◽  
Vol 41 (7) ◽  
pp. 403-405 ◽  
Author(s):  
Ali Varasteh Moradi
Keyword(s):  
Experimental Work ◽  
Ammonium Thiocyanate ◽  
Solvent Free ◽  
Primary Amines ◽  
Acid Chlorides ◽  
One Pot ◽  
One Pot Synthesis ◽  
High Yields ◽  
Work Up ◽  
Solvent Free Synthesis

A one-pot synthesis of indenothiazole derivatives via four-component reactions of ninhydrin, acid chlorides, ammonium thiocyanate and primary amines at 70 °C is described. The method offers several advantages including high yields of products and an easy experimental work-up procedure.

scholarly journals Multicomponent Reactions, Solvent-Free Synthesis of 2-Amino-4-aryl-6-substituted Pyridine-3,5-dicarbonitrile Derivatives, and Corrosion Inhibitors Evaluation

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Naglaa F. H. Mahmoud ◽  
Ahmed El-Sewedy
Keyword(s):  
Aromatic Aldehydes ◽  
Primary Amines ◽  
One Pot ◽  
Multicomponent Condensation ◽  
Wide Range ◽  
Elemental Analyses ◽  
High Yields ◽  
New Compounds ◽  
First Time ◽  
Solvent Free Synthesis

A number of 2-amino-4-aryl-6-substituted pyridine-3,5-dicarbonitrile derivatives were synthesized via one-pot multicomponent condensation reactions of different aromatic aldehydes with malononitrile and different primary amines, using different molecular ratios and different reaction conditions to achieve considerable product yields. Moreover, we succeed, for the first time to develop a new method to synthesize the aforementioned under the fusion condition without using solvent and catalysts. With this method, a wide range of novel 2-amino-3,5-dicyano-4-aryl-6-substituted aminopyridine derivatives were synthesized with high yields and board substrate of functional groups. The synthesized pyridine derivatives were found to have a corrosion inhibition efficiency, the rate of which increased with the increasing concentration of the derivatives. The structures of the new compounds were elucidated by spectroscopic data and elemental analyses.

A One-Pot Synthesis of Functionalised 3-pyrolin-2-ones by a four-component reaction between Triphenylphosphine, Primary Amines, Dimethyl Acetylenedicarboxylate and Ethyl Chlorooxoacetate

2007 ◽  
Vol 2007 (10) ◽  
pp. 574-576 ◽  
Author(s):  
Mohammad Anary-Abbasinejad ◽  
Hossein Anaraki-Ardakani ◽  
Alimohammad Dehghan ◽  
Alireza Hassanabadi ◽  
Mohammad Reza Seyedmir
Keyword(s):  
Primary Amines ◽  
Dimethyl Acetylenedicarboxylate ◽  
One Pot ◽  
One Pot Synthesis ◽  
High Yields

Reaction between triphenylphosphine, dimethy acetylenedicarboxylate and amines produces phosphorus ylids which undergo a smooth reaction with ethyl chlorooxoacetate and triethylamine to produce dimethyl N-aryl-(or alkyl)-4-ethoxy-5-oxo-2,5-dihydro-1 H-pyrole-2,3-dicarboxylates in high yields.

scholarly journals Catalyst-Free, One-Pot, Three-Component Synthesis of Pyrimido[4,5-b] Quinoline-4-Amines under Microwave Irradiation

2018 ◽  
Vol 42 (10) ◽  
pp. 525-528
Author(s):  
Jiao Xu ◽  
Li Hong Zhang ◽  
Xiu Bo Liu ◽  
Wei Ma ◽  
Ling Ma ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Dimethyl Acetal ◽  
Primary Amines ◽  
One Pot ◽  
Catalyst Free ◽  
High Yields

An efficient and facile one-pot, three-component protocol for the synthesis of pyrimido[4,5-b]quinoline-4-amines from the condensation of 2-aminoquinoline-3-carbonitrile, N,N-dimethylformamide dimethyl acetal and primary amines under microwave irradiation is reported. This efficient, straightforward procedure led to the desired products in high yields without the need for a catalyst or for a tandem addition–elimination–cyclisation reaction.

Three-Component One-Pot Reactions of 2-Trifluoromethyl-N-nosylaziridine, Primary Amines, and Vinylsulfonium Salts for Convenient Access to CF3-Containing Piperazines

Synthesis ◽  
2017 ◽  
Vol 49 (11) ◽  
pp. 2488-2494 ◽  
Author(s):  
Kensuke Hirotaki ◽  
Akiko Irie ◽  
Yuki Nakamura ◽  
Takeshi Hanamoto
Keyword(s):  
Primary Amines ◽  
One Pot ◽  
Sequential Reaction ◽  
Vinylsulfonium Salts ◽  
High Yields ◽  
Convenient Access

Trifluoromethylated piperazines were readily synthesized with excellent regioselectivity in high yields by the sequential reaction of 2-trifluoromethylated N-nosylaziridine (2-CF3-N-Ns-aziridine) with various primary amines, followed by treatment with vinylsulfonium salts, in one pot.

scholarly journals An Approach to the Diastereoselective Synthesis of Cyclohexane-1,3-dicarboxamide Derivatives via a Pseudo Five-Component ­Reaction Based on Diketene

Synlett ◽  
2017 ◽  
Vol 29 (02) ◽  
pp. 225-229 ◽  
Author(s):  
Bahareh Talaei ◽  
Majid Heravi ◽  
Hossein Oskooie ◽  
Atieh Rezvanian
Keyword(s):  
Aromatic Aldehydes ◽  
Primary Amines ◽  
Diastereoselective Synthesis ◽  
One Pot ◽  
High Yields

A one-pot pseudo five-component reaction for the synthesis of 2-aryl-4-hydroxy-4-methyl-6-oxo-N 1,N 3-dialkylcyclohexane-1,3-dicarboxamide derivatives involving different primary amines, various aromatic aldehydes, and diketene in the presence of triethylamine with high yields is achieved.

One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole

RSC Advances ◽  
2014 ◽  
Vol 4 (29) ◽  
pp. 15007-15010 ◽  
Author(s):  
Wei Yang ◽  
Yu Zhou ◽  
Haifeng Sun ◽  
Lei Zhang ◽  
Fei Zhao ◽  
...  
Keyword(s):  
Activated Carbon ◽  
Michael Addition ◽  
Primary Amines ◽  
Cascade Process ◽  
One Pot ◽  
Metal Free ◽  
Oxidative Aromatization ◽  
Substituted Pyrroles ◽  
Substrate Tolerance ◽  
High Yields

A metal-free cascade process for the synthesis of highly substituted pyrroles with high yields and broad substrate tolerance via enamine, aza-Michael addition and TBHP, activated carbon oxidative aromatization is reported.

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