scholarly journals Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides

2016 ◽  
Vol 12 ◽  
pp. 1772-1777 ◽  
Author(s):  
Lena Huck ◽  
Juan F González ◽  
Elena de la Cuesta ◽  
J Carlos Menéndez
Keyword(s):  
Single Step ◽  
Side Chain ◽  
One Pot ◽  
Aziridine Ring ◽  
Component Process ◽  
Mild Conditions ◽  
One Step

A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of an aziridine ring. This method allows the preparation of N-unprotected, trisubstituted aziridines bearing a peptide side chain under mild conditions. Their transformation into β-trifluoroacetamido-α-ketoamide and α,β-diketoamide frameworks was also achieved in a single step.

One-step chemoselective conversion of tetrahydropyranyl ethers to silyl-protected alcohols

RSC Advances ◽  
2014 ◽  
Vol 4 (28) ◽  
pp. 14475-14479 ◽  
Author(s):  
Julián Bergueiro ◽  
Javier Montenegro ◽  
Carlos Saá ◽  
Susana López
Keyword(s):  
Single Step ◽  
Protecting Groups ◽  
Reaction Conditions ◽  
One Pot ◽  
Silyl Ethers ◽  
Triple Bonds ◽  
Mild Conditions ◽  
Silyl Groups ◽  
One Step ◽  
Optimal Reaction

A novel chemoselective one-pot transformation of acetals to silyl ethers is reported. Free hydroxyls, double bonds and triple bonds are unaffected in optimal reaction conditions. This practical, inexpensive protocol allows the selective replacement of acetal-forming protecting groups with silyl groups in a single step under mild conditions.

One-step Synthesis of β-lactams Using Cyanuric Fluoride

2013 ◽  
Vol 37 (1) ◽  
pp. 25-27 ◽  
Author(s):  
Maaroof Zarei
Keyword(s):  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
One Step ◽  
Acetic Acids

Cyanuric fluoride works as an efficient acid activator reagent for the direct [2+2] ketene–imine cycloaddition of substituted acetic acids and imines in a one-pot synthesis under mild conditions. The yields are good to excellent and the reaction conditions are mild, simple and efficient.

Progress in One-Pot Synthesis of Methyl Isobutyl Ketone Using Multifunctional Layered Based Catalysts

2013 ◽  
Vol 571 ◽  
pp. 169-196
Author(s):  
Nigamananda Das
Keyword(s):  
Methyl Isobutyl Ketone ◽  
Single Step ◽  
Methyl Isobutyl ◽  
Isobutyl Ketone ◽  
One Pot ◽  
Catalytic Systems ◽  
Step Process ◽  
One Pot Synthesis ◽  
Multifunctional Catalysts ◽  
One Step

Methyl isobutyl ketone (MIBK) is one of the most widely produced and used aliphatic ketones worldwide. The one-step MIBK process with no intermediate separation steps using multifunctional catalysts is an important development towards greener organic synthesis and generates tremendous interest among the researcher across the globe. The single step process is facile and more economically viable and has provided opportunity to develop new and improved catalyst systems capable of operating under mild conditions. A widely variety of catalytic systems have been used in one-step process during last three to four decades. The progress in one-pot synthesis of MIBK using different multifunctional catalysts with special reference to layered based catalysts was critically reviewed in this article.

scholarly journals Efficient and mild synthesis of pyrano-pyrimidines catalyzed by decorated multi-walled carbon nanotubes bearing cobalt, nickel and copper metals in water

2021 ◽  
Author(s):  
Nasrin Saberi Harouni ◽  
Hossein Naeimi
Keyword(s):  
Reaction Times ◽  
Single Step ◽  
High Yield ◽  
One Pot ◽  
H Nmr ◽  
Multi Walled Carbon Nanotubes ◽  
Nmr Techniques ◽  
One Step ◽  
Ft Ir ◽  
Walled Carbon Nanotubes

Abstract Multicomponent reactions are reactions in which three or more are agreeable of raw interests, composed in a one-step chemical process and the product is formed they give. Since multivariate reactions are monovalent reactions and Single-step conversions to ideal synthesis are very close. In this research, one pot three components reaction was carried out between 1, 3-dimethylbarbituric acid, malononitrile and different aldehydes in the attendance of Cu/Co/Ni/MWCNTs as a recyclable catalyst. This catalyst indicated high catalytic actuality with good proficiency and reusable under mild reservation. This reaction is performed fine at ambient temperature. This method proposed numerous materials such as being environmentally amicable for short reaction times and creating high yield products. The catalysts were collected and specified with diversity spectroscopic, such as techniques, such as FT-IR, X-ray fracture, and scanning electron microscopy. After finalization of the reaction, the vintage was obsolete, purified and identified by the melting points, infrared spectroscopy (FT-IR) and the magnetic resonance of the hydrogen nucleus (1H NMR) techniques.

Single-Step Dual Functionalization: One-Pot Bromination-Cross-Dehydrogenative Esterification of Hydroxy Benzaldehydes with CCl3Br – A Comparison with Selectfluor

Synlett ◽  
2019 ◽  
Vol 30 (14) ◽  
pp. 1713-1718 ◽  
Author(s):  
Ranadeep Talukdar
Keyword(s):  
Phenolic Compounds ◽  
Aldehyde Group ◽  
Single Step ◽  
Molecular Bromine ◽  
One Pot ◽  
Blue Led ◽  
Aryl Ring ◽  
Mild Conditions ◽  
Reaction Proceeds ◽  
Phenolic Esters

Bromination of phenolic compounds without directly using molecular bromine possesses much importance. In this article an IrIII/CCl3Br-assisted single-step double functionalization of hydroxy benzaldehydes is reported. It involves simultaneous esterification of the aldehyde group and bromination of the aryl ring of phenolic aldehydes in one-pot. The reaction proceeds under mild conditions in the presence of 445 nm blue LED light to obtain highly functionalized bromo hydroxy benzoates in moderate to good yields. In comparison, Selectfluor as an oxidant gives only non-bromo phenolic esters.

One-step synthesis of high-quality N-doped graphene/Fe3O4 hybrid nanocomposite and its improved supercapacitor performances

RSC Advances ◽  
2014 ◽  
Vol 4 (49) ◽  
pp. 25658-25665 ◽  
Author(s):  
Li Li ◽  
Yuanyun Dou ◽  
Lifeng Wang ◽  
Min Luo ◽  
Jun Liang
Keyword(s):  
Hydrothermal Method ◽  
Hybrid Nanocomposite ◽  
High Quality ◽  
One Pot ◽  
Mild Conditions ◽  
Doped Graphene ◽  
One Step

A series of high-quality N-doped graphene (N-graphene)/Fe3O4 nanocomposites were readily obtained by a simple one-pot hydrothermal method under mild conditions.

Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2675-2679 ◽  
Author(s):  
Chenghui Sun ◽  
Honggang Liang ◽  
Lingxiang Bao ◽  
Yao Du ◽  
Yiying Zhang ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Cyanogen Bromide ◽  
New Method ◽  
Nucleophilic Substitution Reaction ◽  
Tertiary Amines ◽  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
One Step

Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan­amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

scholarly journals Side-chain opening of steroidal sapogenins to form 22-oxocholestanic skeletons. An approach to analogues of the aglycone of the potent anticancer agent OSW-1

2019 ◽  
Vol 53 (3) ◽  
Author(s):  
María A. Fernández-Herrera ◽  
Jesús Sandoval-Ramírez ◽  
Socorro Meza-Reyes ◽  
Sara Montiel-Smith
Keyword(s):  
Anticancer Agent ◽  
2D Nmr ◽  
Starting Material ◽  
Side Chain ◽  
One Pot ◽  
Mild Conditions ◽  
High Yields

The side-chain opening of 25R and 25S steroidal sapogenins to form 22-oxocholestanic skeletons is described. The transformation was produced under mild conditions providing high yields (70-87%), in a one pot procedure (some acetylated starting material is recovered). This methodology yields 17-deoxy-26-oxy analogues of the aglycone of the potent anticancer agent OSW-1. All products were fully characterized by 1D and 2D NMR; the most representative displacements are briefly discussed.    

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