scholarly journals A concise assessment of salivary modifications in patients with chronic hepatitis

2017 ◽  
Vol 12 (3) ◽  
pp. 152-157
Author(s):  
Daniela-Gabriela BADITA ◽  
◽  
Dan PIPEREA-SIANU ◽  
Andra-Elena BALCANGIU-STROESCU ◽  
Bogdan CALENIC ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Healthy Subjects ◽  
Alcoholic Hepatitis ◽  
Biological Fluid ◽  
Statistical Significance ◽  
Chronic Viral Hepatitis ◽  
Systemic Diseases ◽  
Chronic Alcoholic ◽  
Alt Alanine Aminotransferase

Background. Saliva is a complex biological fluid that has great potential as a diagnosis fluid for both oral and systemic diseases. At the same time, chronic hepatitis affects millions of people worldwide and can lead to liver cirrhosis and hepatocellular carcinoma. In this context, our research group aimed to evaluate the modifications produced in the saliva of patients with chronic hepatitis compared to healthy subjects. Material and method. The present work included 88 subjects that were divided into 4 groups, each consisting of 22 people. Saliva samples were collected for each participant to the study. Salivary levels of total protein (TP), IgA, IgG and aminotransferases AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were determined. Results. Our results showed significantly increased salivary levels of TP, IgA, AST and ALT for patients with chronic viral hepatitis (CHV) and chronic alcoholic hepatitis (CAH) compared to controls. IgG salivary levels were also higher in patients with hepatitis versus controls, however while statistical significance could be found for patients with chronic hepatitis C (CHC) and CAH, this was not the case for the patients with chronic hepatitis B (CHB). Conclusions. The results of our study showed significantly increased salivary levels of the determined parameters in hepatitis patients compared to the healthy subjects, hence promoting the use of saliva as a diagnosis and monitoring fluid for chronic hepatitis.

scholarly journals Serum Zonulin in HBV-Associated Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Xin Wang ◽  
Ming-ming Li ◽  
Ye Niu ◽  
Xin Zhang ◽  
Ji-bin Yin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Diagnostic Accuracy ◽  
Roc Curve ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Curve Analysis ◽  
Advanced Stage ◽  
Roc Curve Analysis

Background. The gut microbiota is involved in the occurrence and development of chronic liver diseases. Zonulin is considered a marker of intestinal permeability. The purpose of this study was to assess zonulin levels in patients with chronic hepatitis B (CHB), HBV-associated liver cirrhosis (LC), and HBV-associated hepatocellular carcinoma (HCC). Materials and Methods. The study population consisted of 90 HBV-associated HCC patients, 90 HBV-associated LC patients, 90 CHB patients, and 90 healthy subjects. Serum levels of zonulin and AFP were determined. The diagnostic accuracy of each marker was evaluated using receiver operating characteristic (ROC) curve analysis (AUC). Results. Serum zonulin levels were significantly higher in patients with HCC than in patients with LC or CHB or healthy subjects (p<0.001). Moreover, the zonulin levels were increased in the advanced stage of LC and HCC. ROC curve analysis revealed that serum zonulin could be used to differentiate CHB from cirrhosis. In addition, the combination of zonulin and AFP exhibited a significantly larger AUC compared with zonulin or AFP alone. Conclusions. Serum zonulin levels were significantly increased both in LC and in HCC and correlated with the advanced stage of LC and HCC. Moreover, the combination of zonulin and AFP confers significant benefit to diagnostic accuracy in differentiating LC from HCC.

scholarly journals Comparative evaluation of various strategies medical care for chronic hepatitis С in the Republic of Sakha (Yakutia)

2021 ◽  
Vol 13 (1) ◽  
pp. 88-96
Author(s):  
S. S. Sleptsova ◽  
S. S. Sleptsov ◽  
V. K. Semenova
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Medical Care ◽  
Viral Hepatitis ◽  
Chronic Hepatitis C ◽  
Public Health Problem ◽  
Chronic Viral Hepatitis ◽  
Decompensated Cirrhosis ◽  
Major Public Health Problem

Hepatitis C is a major public health problem and measures against it require the development of a national strategy and concept of a prognostic model. This is relevant for Yakutia, as a tremendous region with extremely specific and severe climatic and social conditions that cause a high incidence of hepatitis C.Objective: to evaluate the effectiveness of various scenarios for the development of the epidemiological situation of hepatitis C in RS (Y) depending on the strategy for providing medical care to people with chronic hepatitis C.Material and Methods. The work uses the materials of official statistics of the Federal State Institution of Rospotrebnadzor for RS (Y) and information from the register «Chronic viral hepatitis in RS (Y). To assess the burden of disease, the main scenarios were analyzed using the dynamic Excel model.Results and discussion. RS (Y) is a disadvantaged territory of the Russian Federation for parenteral viral hepatitis, including hepatitis C. According to the register «Chronic viral hepatitis in RS (Y)», 14643 people are registered, of which with chronic hepatitis C — 7395, which amounted to 50,5%. The proportion of HCV infection in the group of people with cirrhosis is 44.1%, with hepatocellular carcinoma 59,3%, and 76% in the total structure of the dead. Implementation of the WHO scenario for hepatitis C will reduce mortality by 65%, the number of people with hepatocellular carcinoma by 66%, decompensated cirrhosis by 66% and reduce the overall incidence by 34% by 2030.Conclusion. Achieving the WHO goals by 2030 seems realistic when creating a regional strategy to eliminate HCV in RS (Y), which includes increasing access to therapy with modern drugs with direct antiviral effects, an interdisciplinary approach to the diagnosis and management of patients with chronic hepatitis C, specialties about the problem of chronic hepatitis C and the possibility of curing it.

scholarly journals Liver cirrhosis and hepatocellular carcinoma in patients with chronic viral hepatitis c: some epidemiologic and molecular-genetic aspects

2014 ◽  
Vol 19 (2) ◽  
pp. 40-51
Author(s):  
L. I Nikolaeva ◽  
E. A Leybman ◽  
G. V Sapronov ◽  
A. N Yudin
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Molecular Genetic ◽  
Genetic Data ◽  
Chronic Viral Hepatitis ◽  
Molecular Genetic Data ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

The aim of this review is to analyze the modern epidemiological and molecular-genetic data concerning development of liver cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis C. There were considered peculiarities of the occurrence of this pathology in adult patients and children with hepatitis C.

Effect of human galanin on the response of circulating catecholamines to hypoglycemia in man

1995 ◽  
Vol 133 (6) ◽  
pp. 723-728 ◽  
Author(s):  
Ettore C degli Uberti ◽  
Maria R Ambrosio ◽  
Marta Bondanelli ◽  
Giorgio Transforini ◽  
Alberto Valentini ◽  
...  
Keyword(s):  
Heart Rate ◽  
Healthy Subjects ◽  
Sympathetic Nerve Activity ◽  
Heart Rate Response ◽  
Statistical Significance ◽  
Inhibitory Effect ◽  
Amino Acid Residues ◽  
Nerve Activity ◽  
Receptor Stimulation

degli Uberti EC, Ambrosio MR, Bondanelli M, Trasforini G, Valentini A, Rossi R, Margutti A, Campo M. Effect of human galanin on the response of circulating catecholamines to hypoglycemia in man. Eur J Endocrinol 1995;133:723–8. ISSN 0804–4643 Human galanin (hGAL) is a neuropeptide with 30 amino acid residues that has been found in the peripheral and central nervous system, where it often co-exists with catecholamines. In order to clarify the possible role of hGAL in the regulation of sympathoadrenomedullary function, the effect of a 60 min infusion of hGAL (80 pmol·kg−1 · min−1) on plasma epinephrine and norepinephrine responses to insulin-induced hypoglycemia in nine healthy subjects was investigated. Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Human GAL significantly increased the heart rate in resting conditions and clearly exaggerated the heart rate response to insulin-induced hypoglycemia, whereas it had no effect on the blood pressure. We conclude that GAL receptor stimulation exerts an inhibitory effect on basal and insulin-induced hypoglycemia-stimulated release of norepinephrine. These findings provide further evidence that GAL may modulate sympathetic nerve activity in man but that it does not play an important role in the regulation of adrenal medullary function. Ettore C degli Uberti, Chair of Endocrinology, University of Ferrara, Via Savonarola 9, I-44100 Ferrara, Italy

Sign in / Sign up

Export Citation Format

Share Document