scholarly journals DIAGNOSIS AND TREATMENT IN GASTROESOPHAGEAL REFLUX DISEASE – POSSIBILITIES AND LIMITATIONS

2016 ◽  
Vol 65 (3) ◽  
pp. 249-253
Author(s):  
Gabriela Ciubotariu ◽  
◽  
Smaranda Diaconescu ◽  
Angelica Cristina Marin ◽  
Claudia Olaru ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Surgical Intervention ◽  
Pharmacologic Therapy ◽  
First Year ◽  
Endoscopic Myotomy ◽  
The Common ◽  
One Year ◽  
First Year Of Life

In children’s first year of life it is mandatory to make a difference between physiological gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD), in order to avoid an aggressive pharmacologic therapy. All ages of childhood benefit from modern criteria of clinical evaluation, by corroborating the digestive or extra digestive symptoms with the results of modern investigations. The dietary measures (sufficient in GER but mandatory in all cases) together with proton pump inhibitors administration after one year of age induce remission in majority of GER cases. The chronic and recurrent evolution of the disease or failure of the common treatment require surgical intervention, recently enriched in children with peroral endoscopic myotomy (POEM).

scholarly journals Association of Treated and Untreated Gastroesophageal Reflux Disease in the First Year of Life with the Subsequent Development of Asthma

2021 ◽  
Vol 18 (18) ◽  
pp. 9633
Author(s):  
Anna Cantarutti ◽  
Claudio Barbiellini Amidei ◽  
Camilla Valsecchi ◽  
Antonio Scamarcia ◽  
Giovanni Corrao ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Subsequent Development ◽  
First Year ◽  
Risk Increase ◽  
Hazard Ratios ◽  
Increased Risk ◽  
First Year Of Life ◽  
Clinical Asthma

Introduction: Gastroesophageal reflux disease (GERD) as well as its treatment with acid-suppressive medications have been considered possible risk factors for the development of asthma, but few studies have disentangled the role of GERD with that of its treatment. The present study aimed at estimating the association of treated and untreated GERD in the first year of life with the risk of asthma. Methods: Retrospective cohort study including all children born between 2004 and 2015 registered in Pedianet, an Italian primary care database. We analyzed the association of children exposed to GERD (both treated and untreated) in the first year of life with the risk of developing clinically assessed asthma (clinical asthma) after 3 years. Secondary outcomes included asthma identified by anti-asthmatic medications (treated asthma) and wheezing after 3 years. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated comparing children with and without GERD, stratifying by treatment with acid-suppressive medications. Results: Out of 86,381 children, 1652 (1.9%) were affected by GERD in the first year of life, of which 871 (53%) were treated with acid-suppressive medications. Compared with controls, children with GERD were at increased risk of clinical asthma (HR: 1.40, 95% CI 1.15–1.70). Risks were similar between treated and untreated GERD (p = 0.41). Comparable results were found for treated asthma, but no risk increase was seen for wheezing. Discussion: Early-life GERD was associated with subsequent childhood asthma. Similar risks among children with treated and untreated GERD suggest that acid-suppressive medications are unlikely to play a major role in the development asthma.

New Endoscopic Techniques

2018 ◽  
Author(s):  
Phillip S Ge ◽  
Christopher C Thompson
Keyword(s):  
Radiofrequency Ablation ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Endoscopic Submucosal Dissection ◽  
Endoscopic Mucosal Resection ◽  
Reflux Disease ◽  
Endoscopic Management ◽  
Endoscopic Techniques ◽  
Endoscopic Myotomy ◽  
Pseudocyst Drainage

Major advancements in endoscopic techniques have allowed for the minimally invasive endoscopic management of many diseases that previously required surgical intervention. This review briefly describes major advances in endoscopic resection, including endoscopic mucosal resection and endoscopic submucosal dissection; endoscopic ablation, including radiofrequency ablation and cryotherapy; submucosal endoscopy, including peroral endoscopic myotomy and submucosal tunneling endoscopic resection; endoscopic access, including biliary access, pseudocyst drainage and direct endoscopic necrosectomy, and endoscopic gastrojejunostomy; endoscopic management of gastroesophageal reflux disease; and endoscopic management of obesity. Owing to the broad range of topics covered, extensive primary literature is provided for further reference for the interested reader. This review contains 8 figures and 55 references Key words: bariatric endoscopy, direct biliary access, endoscopic mucosal resection, endoscopic submucosal dissection, gastroesophageal reflux disease, gastrojejunostomy, peroral endoscopic myotomy, pseudocyst drainage, radiofrequency ablation, submucosal tumors

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