functional factors
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2021 ◽  
pp. 17-27
Author(s):  
Hennadiy Haiko ◽  
Іllia Savchenko ◽  
Nataliya Pankratova

Purpose: Determining construction priorities of underground transport infrastructure objects by evaluating morphological models of car tunnels considering the impact on the ecological and technogenic safety of urbanized territories. Methodology: modified morphological analysis of geological environment, urbanized territories and transport infrastructure of sites in a metropolis, expert estimation method. Findings: a morphological model was tested as a tool set for determining construction priorities of underground transport infrastructure objects; inter-related morphological tables for geological environment and structural-functional factors of urbanized territories in a tunnel area were constructed; an estimation of models regarding development of underground infrastructure was conducted using the planned car tunnels in Kyiv as an example; the impact of tunnels on reducing the ecological and technogenic risks of urbanized space was justified, and the priority construction object was chosen according to these criteria. Originality: for the first time the reduction of ecological and technogenic risks of urbanized space was chosen as a goal function in morphological models for the development of underground transport infrastructure in metropolises; the systemic characteristics of urban territories were obtained that describe the favorability of the geological environment and structural-functional factors for car tunnel construction in center metropolis areas; an impact ratio was proposed for synthesizing morphological analysis results and determining the priorities of underground transport infrastructure objects by influence on the ecological and technogenic risks. Practical implications: the created methodology and tool set for determining priorities of underground object construction at the pre-project stage, the opportunity to consider the ecological and technogenic risks of urban space development by consecutive construction of underground transport infrastructure objects and identifying an order for this sequence.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Qing-Lan Li ◽  
Xiang Lin ◽  
Ya-Li Yu ◽  
Lin Chen ◽  
Qi-Xin Hu ◽  
...  

AbstractColorectal cancer is one of the most common cancers in the world. Although genomic mutations and single nucleotide polymorphisms have been extensively studied, the epigenomic status in colorectal cancer patient tissues remains elusive. Here, together with genomic and transcriptomic analysis, we use ChIP-Seq to profile active enhancers at the genome wide level in colorectal cancer paired patient tissues (tumor and adjacent tissues from the same patients). In total, we sequence 73 pairs of colorectal cancer tissues and generate 147 H3K27ac ChIP-Seq, 144 RNA-Seq, 147 whole genome sequencing and 86 H3K4me3 ChIP-Seq samples. Our analysis identifies 5590 gain and 1100 lost variant enhancer loci in colorectal cancer, and 334 gain and 121 lost variant super enhancer loci. Multiple key transcription factors in colorectal cancer are predicted with motif analysis and core regulatory circuitry analysis. Further experiments verify the function of the super enhancers governing PHF19 and TBC1D16 in regulating colorectal cancer tumorigenesis, and KLF3 is identified as an oncogenic transcription factor in colorectal cancer. Taken together, our work provides an important epigenomic resource and functional factors for epigenetic studies in colorectal cancer.


2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi155-vi155
Author(s):  
Mitsutoshi Nakada ◽  
Riho Nakajima ◽  
Hirokazu Okita ◽  
Masashi Kinoshita

Abstract In glioma surgeries, cognitive outcomes for the dominant hemisphere have gained much attention compared to the non-dominant hemisphere. For non-dominant hemispheric glioblastomas, we previously observed decreased independence level following glioblastoma resection of the posterior temporal to the parietal lobes. Here, we investigated the reason for the poor Karnofsky Performance Status (KPS) in such glioblastomas. A total of 41 patients with resection of the right cerebral hemispheric primary glioblastoma were enrolled for the study. Several kinds of neuropsychological functions and KPS of the brain regions were evaluated at pre- and postoperative 3 months by performing the Spearman’s correlation analysis and voxel-based lesion symptom mapping (VLSM). Additionally, the correlation between the resected volume of each gyrus or white matter tract and neuropsychological function score was analyzed. KPS at chronic phase (73.6) declined significantly compared with preoperation (81.0, p = 0.020). Functional factors influencing the KPS were general cognitive function, visuospatial cognition, emotion recognition, executive function, and apathy. The VLSM analysis revealed that the resection of the ventral parietal lobe and supramarginal gyrus (VPL-SMG) resulted in significantly poor KPS. Among the functional factors affecting KPS, VPL-SMG resection contributed to significantly lower scores in visuospatial cognition, emotion recognition, and apathy than those without resection (p = 0.0045, 0.047, and 0.0002, respectively). Further, we investigated whether the damage of the VPL-SMG could result in KPS related functional deficit. We found visuospatial cognition related to the posterior occipital lobe, SMG, arcuate fasciculus (AF), and dorsal superior longitudinal fasciculus, emotion recognition to the middle to inferior occipital gyrus and AF, and apathy to the inferior parietal lobe and middle temporal gyrus. We concluded that deficits of visuospatial cognition, emotion recognition, and apathy due to the damage of the cortical and white matter areas, including the VPL-SMG, were responsible for KPS of the non-dominant hemispheric glioblastomas.


2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi186-vi187
Author(s):  
Riho Nakajima ◽  
Masashi Kinoshita ◽  
Hirokazu Okita ◽  
Mitsutoshi Nakada

Abstract Awake surgery is performed aiming for maintaining postoperative quality of life (QOL) by preserving brain function. Nowadays, it is not known whether QOL is certainly maintained in gliomas who underwent awake surgery, and which brain functions contribute to maintain their postoperative QOL. Here we investigated QOL following awake surgery, and to determine their background and functional factors influencing on QOL. Totally 80 patients with gliomas were matched our inclusion criteria. SF-36 was performed for assessment of QOL. Three component scores including physical component summary (PCS), mental component summary (MCS), and role/social component summary (RCS) were calculated, and were compared them with that of normal healthy controls. Additionally, neurological/neuropsychological functions were evaluated at pre- and post-operative six months. Multiple regression analyses were used to investigate functional and sociodemographic/clinical factors influencing on SF-36. RCS but not PCS and MCS in patient group was significantly lower than that of normal controls (p< .0001). Then, we investigated sociodemographic/clinical factors influencing on RCS, and found two significant factors, returning to social life and malignancy grade (p=0.011 and 0.022, respectively). The primary reasons for difficulty in returning to social life were functional deficits including aphasia and paresis. Among functional factors, RCS significantly related to motor function and verbal fluency (p= 0.0042 and 0.040, respectively). To support the results, RCS in deficit group for movement and verbal fluency was significantly low than in non-deficit group (Wilcoxon test, p=0.037 and 0.044, respectively). Among factors influencing on RCS, sociodemographic/clinical factors were returning to social life and malignancy grade, while functional factors were motor function and verbal fluency.


2021 ◽  
Vol 2 (6) ◽  
pp. 199-205
Author(s):  
Lyudmila P. Dianova ◽  
◽  
Nina V. Shchennikova ◽  
Elena V. Polyakova

The purpose of this article is a dynamic analysis of the transformations taking place in the speech culture of bilingual students of the post-Soviet space. Russian-foreign bilingualism, as our survey shows, has undergone a certain reconfiguration over the past decade. Previous experiments convincingly proved that the Russian language is dominant in the speech culture of bilingual students, which was due to a number of estralinguistic and linguistic-functional factors. Autochthonous languages in the cognitive structure of students occupied a less stable position and were communicatively limited even in conditions of microdiscursive functioning. It was safe to say that Russian was the core of the linguistic consciousness of bilingual students. Today the situation has changed. The role of autochthonous languages is signified. The Russian language still remains a communicative dominant, providing the basic communicative needs of the individual (including the need for training and the formation of professional competencies), however, it is gradually shifting from the core towards the center, which may indicate that linguo-constructive functions in the future may be lost, and new ones associated with the ethnically primary language have not yet been formed (taking into account the small historical time), which will entail the phenomenon of mass semilingualism.


Glottotheory ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mayowa Akinlotan

Abstract Syntactic alternation allows us to understand how structural variation, including crucial factors relevant to their meaning and interpretation, operates linguistic varieties. Empirical evidence from such syntactic alternation study can provide insights into how new varieties differ from the established ones. The present study aims at increasing contributions that show the nature of syntactic alternation from new Englishes such as Nigerian English, and how they differ from established varieties such as British English. Taking when adverbial construction in Nigerian English as a reference point (When Trump realised his reelection loss, he changed his political expectations versus Trump changed his political expectations when he realised his reelection loss), the study shows the extent to which previously tested factors influence the ordering of the construction and how they differ from findings reported in British English. Relying on corpus data, together with descriptive distributional analysis, the study shows that, unlike British English in which functional and cognitive factors strongly influence structural patterning, functional factors outweigh cognitive factors in Nigerian English.


Author(s):  
Juliana M. M. Barbosa ◽  
Juleimar S. C. Amorim ◽  
Fabianna R. Jesus Moraleida ◽  
Vitor T. M. Rocha ◽  
Juscelio P. da Silva ◽  
...  

2021 ◽  
pp. 239448112110203
Author(s):  
Koustubh Kanti Ray

Numerous studies are available in the academic literature that investigates the customer perception under different contexts. In the present research the researcher tries to investigate the customer perception towards the Indian Government-sponsored social programme from the slum dwellers’ prospective. The author believes that the customer perception towards the government-lead liquefied petroleum gas intervention programme is influenced by multiple functional factors. The functional factors include both process or delivery variables and the outcome factors. In order to test the hypothesis, machine learning binary classifiers like logit, support vector machine, linear discriminant analysis, quadratic discriminant analysis and artificial neural network models are adopted. The binary classifier model efficiencies are analysed with multiple performance measurement parameters like accuracy rate, error rate, F-score, precision, kappa coefficient, Matthews correlation coefficient and area under receiver operating characteristic. While evaluating between the degree of accuracy between actual and predicted cases, the model efficiency results indicate a better predictive power of the classifier models. In relative performance of classifier models, artificial neural network outperformed the other models adopted in the empirical research.


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