scholarly journals Clinical and functional evaluation in patients with upper limb disability following traumatic peripheral nerve injury. Part I

2015 ◽  
Vol 62 (3) ◽  
pp. 243-248
Author(s):  
Mariana-Isabela Moise (Constantinovici) ◽  
◽  
Adriana Sarah Nica ◽  
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Biomedical Literature ◽  
Motor Dysfunction ◽  
Functional Evaluation ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Upper Limb Function ◽  
Neurologic Impairment

Background. Current studies regarding the consequences of upper limb traumatic peripheral nerve injuries adresses both sensory-motor dysfunction and functioning, disability and pain issues. Aims. This article presents an overview of the biomedical literature regarding the available assessment methodologies and outcome measures used in research and clinical practice for the evaluation of upper limb function in the therapeutic management of posttraumatic upper limb peripheral nerve injuries and disability and their impact on patient’s functioning, health and quality of life. Design. Systematic review of the international biomedical literature. Methods. We used PubMedCentral database searches (PMC) of the last 10 years published literature. There were excluded scientific abstracts and articles that did not match to our search criteria, such as studies on brachial plexus injury, diabetic neuropathy, upper limb neurologic impairment due to Stroke, TBI or SCI, etc. Results and discussion. We selected 20 studies from the identified articles. We presented an overview of the main assessment methodologies and functional parameteres investigated in these studies.

scholarly journals Clinical and functional evaluation in patients with upper limb disability following traumatic peripheral nerve injury. Part II

2015 ◽  
Vol 62 (4) ◽  
pp. 367-370
Author(s):  
Mariana-Isabela Moise (Constantinovici) ◽  
◽  
Adriana Sarah Nica ◽  
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Biomedical Literature ◽  
Motor Dysfunction ◽  
Functional Evaluation ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Upper Limb Function ◽  
Neurologic Impairment

Background. Current studies regarding the consequences of upper limb traumatic peripheral nerve injuries adresses both sensory-motor dysfunction and functioning, disability and pain issues. Aims. This article presents an overview of the biomedical literature regarding the available assessment methodologies and outcome measures used in research and clinical practice for the evaluation of upper limb function in the therapeutic management of posttraumatic upper limb peripheral nerve injuries and disability and their impact on patient’s functioning, health and quality of life. Design. Systematic review of the international biomedical literature. Methods. We used PubMedCentral database searches (PMC) of the last 10 years published literature. There were excluded scientific abstracts and articles that did not match to our search criteria, such as studies on brachial plexus injury, diabetic neuropathy, upper limb neurologic impairment due to Stroke, TBI or SCI, etc. Results and discussion. We selected 20 studies from the identified articles. We presented an overview of the main assessment methodologies and functional parameters investigated in these studies.

scholarly journals Stabilization, Rolling, and Addition of Other Extracellular Matrix Proteins to Collagen Hydrogels Improve Regeneration in Chitosan Guides for Long Peripheral Nerve Gaps in Rats

Neurosurgery ◽  
2017 ◽  
Vol 80 (3) ◽  
pp. 465-474 ◽  
Author(s):  
Francisco Gonzalez-Perez ◽  
Stefano Cobianchi ◽  
Claudia Heimann ◽  
James B. Phillips ◽  
Esther Udina ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Standard Technique ◽  
Biologically Active ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Critical Gap ◽  
The Right

Abstract BACKGROUND: Autograft is still the gold standard technique for the repair of long peripheral nerve injuries. The addition of biologically active scaffolds into the lumen of conduits to mimic the endoneurium of peripheral nerves may increase the final outcome of artificial nerve devices. Furthermore, the control of the orientation of the collagen fibers may provide some longitudinal guidance architecture providing a higher level of mesoscale tissue structure. OBJECTIVE: To evaluate the regenerative capabilities of chitosan conduits enriched with extracellular matrix-based scaffolds to bridge a critical gap of 15 mm in the rat sciatic nerve. METHODS: The right sciatic nerve of female Wistar Hannover rats was repaired with chitosan tubes functionalized with extracellular matrix-based scaffolds fully hydrated or stabilized and rolled to bridge a 15 mm nerve gap. Recovery was evaluated by means of electrophysiology and algesimetry tests and histological analysis 4 months after injury. RESULTS: Stabilized constructs enhanced the success of regeneration compared with fully hydrated scaffolds. Moreover, fibronectin-enriched scaffolds increased muscle reinnervation and number of myelinated fibers compared with laminin-enriched constructs. CONCLUSION: A mixed combination of collagen and fibronectin may be a promising internal filler for neural conduits for the repair of peripheral nerve injuries, and their stabilization may increase the quality of regeneration over long gaps.

Traumatic peripheral nerve injuries: epidemiological findings, neuropathic pain and quality of life in 158 patients

2010 ◽  
Vol 15 (2) ◽  
pp. 120-127 ◽  
Author(s):  
Palma Ciaramitaro ◽  
Mauro Mondelli ◽  
Francesco Logullo ◽  
Serena Grimaldi ◽  
Bruno Battiston ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Neuropathic Pain ◽  
Peripheral Nerve ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries

Cervical and Upper Limb Peripheral Nerve Injuries in Adults: Electrodiagnostic Studies and Symptoms

2017 ◽  
Vol 23 (3) ◽  
Author(s):  
Bina Eftekharsadat ◽  
Arash Babaei-Ghazani ◽  
Bahram Samadirad ◽  
Vida Mamaghany
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries

Electroactive nanomaterials in the peripheral nerve regeneration

2021 ◽  
Author(s):  
Xiangyun Yao ◽  
Yun Qian ◽  
Cunyi Fan
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Life Quality ◽  
Peripheral Nerve Injuries ◽  
Human Beings ◽  
Nerve Injuries

Severe peripheral nerve injuries are threatening the life quality of human beings.

Quality of Life and Psychosocial Factors as Predictors of Pain Relief Following Nerve Surgery

Hand ◽  
2020 ◽  
pp. 155894472091121 ◽  
Author(s):  
Kartemus O. Heary ◽  
Alex W. K. Wong ◽  
Stephen C. L. Lau ◽  
Jana Dengler ◽  
Madeline R. Thompson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Peripheral Nerve ◽  
Psychosocial Factors ◽  
Self Report ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Peripheral Nerve Surgery ◽  
Nerve Surgery ◽  
The Impact

Background: Peripheral nerve injuries may result in pain, disability, and decreased quality of life (QoL). Pain is an incompletely understood experience and is associated with emotional and behavioral qualities. We hypothesized that pain following peripheral nerve surgery could be predicted by changes in emotions or QoL postoperatively. Methods: Using prospectively collected data, a retrospective study design was used to evaluate the relationships among pain, QoL, and psychosocial factors in patients who underwent peripheral nerve surgery. Patients completed questionnaires rating pain; impact of pain on QoL, sadness, depression, frustration, anger, and hopefulness before surgery; and each postoperative follow-up visit. Multilevel modeling was used to assess the concurrent and lagged relationships between pain and psychosocial factors. Results: Increased pain was concurrently associated with decreased hopefulness ( P = .001) and increased the impact on QoL, sadness, depression, and anger ( P < .001). In lagged analyses, the impact on QoL and anger prospectively predicted pain ( P < .001 and P = .02, respectively). Pain predicted subsequent scores of QoL, sadness, depression, anger, and hopefulness ( P < .01). Having an upper limb nerve injury and self-report of “no comment for childhood trauma” were predictors of postsurgical pain. Conclusion: Psychosocial measures and pain are reciprocally related among patients who underwent surgery for peripheral nerve injuries or compression. Our study provides evidence of the important relationships among psychosocial factors, pain, and outcome and identifies treatment targets following nerve surgery.

Tendon transfers after peripheral nerve injuries: my preferred techniques

2019 ◽  
Vol 44 (8) ◽  
pp. 775-784 ◽  
Author(s):  
Vincent R. Hentz
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Hand Function ◽  
Nerve Transfer ◽  
Peripheral Nerve Injuries ◽  
Reconstructive Procedure ◽  
Nerve Injuries ◽  
Postoperative Rehabilitation ◽  
Tendon Transfers ◽  
To Come

While there is now keen interest in restoring function lost through irreparable nerve injury by performing nerve-to-nerve transfer, for some time to come, tendon transfers will remain the primary reconstructive procedure for paralytic injuries of the upper limb. A career spanning more than 50 years has permitted the author to try many tendon transfers promoted by past and present colleagues for the three common nerve injuries (median, radial and ulnar) affecting hand function and, eventually, to settle upon those which have provided the most predictable and consistent outcomes. This article describes the author’s preferred tendon transfers for high radial and low median and ulnar palsies, providing the rationale behind these choices, operative details supplemented with illustrations, technical tips and advice regarding postoperative rehabilitation.

The Epidemiology and Management of Upper Limb Peripheral Nerve Injuries in Modern Practice

1996 ◽  
Vol 21 (1) ◽  
pp. 4-13 ◽  
Author(s):  
R. M. R. McALLISTER ◽  
S. E. A. GILBERT ◽  
J. S. CALDER ◽  
P. J. SMITH
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Upper Limb ◽  
Primary Repair ◽  
Nerve Repair ◽  
Peripheral Nerve Injuries ◽  
Nerve Injuries ◽  
Frequency Distributions ◽  
South East England ◽  
Delayed Referral

This paper reports an epidemiological and clinical study of 813 patients with 1,111 peripheral nerve injuries who were treated for upper limb trauma, which included nerve injury, at two plastic surgery units in south-east England, predominantly between the years 1982 and 1991. The frequency distributions of the levels of nerve injury, and the causes of nerve injury in the sample, are presented, together with the surgical management and timing of nerve repair in these patients. 1,018 clinically suspected nerve injuries in 730 patients (91.6% of nerves, 89.8% of patients) were treated by primary nerve repair, elective delayed nerve repair or primary surgical exploration alone. Divisions of 93 nerves in 83 patients (8.3% of nerves, 10.2% of patients) were treated other than by primary repair or elective delayed repair, due to delayed referral from accident and emergency departments, resulting from missed or uncertain diagnosis at presentation or otherwise unaccounted delay in the initial referral.

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