scholarly journals Fertility sparing surgery in malignant ovarian germ cell tumors (MOGCTs): 15 years experiences

2021 ◽  
Author(s):  
Shima Alizadeh ◽  
Narges Zamani ◽  
Mohadese Rezaei Poor ◽  
Sedigheh Ghasemian Dizajmehr ◽  
Mitra Modares Gilani
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

scholarly journals Treatment outcomes in malignant ovarian germ cell tumors

2017 ◽  
Vol 6 (12) ◽  
pp. 5256
Author(s):  
Ram Kumar B.
Keyword(s):  
Germ Cell ◽  
Chemotherapy Regimen ◽  
Primordial Germ Cells ◽  
Germ Cell Tumour ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Germ Cell Tumours ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Yolk Sac Tumour

Background: Malignant ovarian germ cell tumours are rare group of ovarian neoplasms derived from primordial germ cells of the ovary. Objective of present study was to evaluate the outcome of treatment in malignant germ cell tumours.Methods: 21 Patients of malignant ovarian germ cell tumours registered at Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Chennai for the period from January 2012 to December 2015 were retrospectively analyzed for treatment outcomes.Results: The median age at presentation was 21 years with age range between 14 and 40 years. 9patients (43%) presented with mixed germ cell tumour, 6 patients (29%) with dysgerminoma, 3 patients (14%) with yolk sac tumour and 3 patients (14%)with mature cystic teratoma. 13 patients (62%) presented with Stage I disease, 5 patients (24%) with Stage III and 3 patients (14%) with Stage II. Fertility sparing surgery was done in 15 patients (71%), and 4 patients (19%) who completed family had TAH with BSO done. Adjuvant Chemotherapy was given for 16 patients (76%) and as Neoadjuvant in 2patients (10%) who had biopsy alone performed. 4patients (19%) developed recurrence and was taken for salvage PVI chemotherapy.Conclusions: Malignant ovarian germ cell tumours are relatively uncommon neoplasms characterized by high chemo sensitivity. This study confirms that malignant ovarian germ cell tumours have excellent prognosis and the effectiveness of BEP chemotherapy regimen. Fertility sparing surgery is feasible in most cases. Advanced Stage configured as an important risk factor for survival. The chemotherapy regimen was associated with significant but manageable toxicity.

scholarly journals Reproductive Outcomes and Fertility Preservation Strategies in Women with Malignant Ovarian Germ Cell Tumors after Fertility Sparing Surgery

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 554
Author(s):  
Francesca Maria Vasta ◽  
Miriam Dellino ◽  
Alice Bergamini ◽  
Giulio Gargano ◽  
Angelo Paradiso ◽  
...  
Keyword(s):  
Germ Cell ◽  
Fertility Preservation ◽  
Therapeutic Option ◽  
Germ Cell Tumors ◽  
Oncological Outcome ◽  
Reproductive Age ◽  
Premature Menopause ◽  
Reproductive Outcomes ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Malignant ovarian germ cell tumors are rare tumors that mainly affect patients of reproductive age. The aim of this study was to investigate the reproductive outcomes and fertility preservation strategies in malignant ovarian germ cell tumors after fertility-sparing surgery. Data in literature support that fertility-sparing surgery is associated with an excellent oncological outcome not only in early stages malignant ovarian germ cell tumors but also in advanced stages. Moreover, the possibility of performing conservative treatment should be considered even in case of relapse or advanced disease, given the high chemosensitivity. Indeed, available data have shown that menstrual function is maintained after platinum-based regimens in over 85–95% of patients with malignant ovarian germ cell tumors and rate of premature menopause reported in literature ranges between 3% and 7.4%, while premature ovarian failure rates are between 3.4% and 5%. Moreover, reproductive outcomes are about 80% with no increase in the risk of teratogenicity compared to general population. Therefore, conservative surgery for malignant ovarian germ cell tumors currently may represent a therapeutic option in patients who wish to preserve fertility but must be available for extended follow-up and after subscribing to informed consent.

Analysis of outcomes and prognostic factors after fertility-sparing surgery in malignant ovarian germ cell tumors

2017 ◽  
Vol 145 (3) ◽  
pp. 513-518 ◽  
Author(s):  
Jeong-Yeol Park ◽  
Dae-Yeon Kim ◽  
Dae-Shik Suh ◽  
Jong-Hyeok Kim ◽  
Yong-Man Kim ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Management of Ovarian Germ Cell Tumors

2007 ◽  
Vol 25 (20) ◽  
pp. 2938-2943 ◽  
Author(s):  
David M. Gershenson
Keyword(s):  
Prognostic Factors ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Reproductive Function ◽  
Advanced Stage ◽  
Early Stage Disease ◽  
Fertility Sparing Surgery ◽  
Stage Disease ◽  
Fertility Sparing ◽  
Cure Rates

Purpose To review contemporary management of malignant ovarian germ cell tumors (MOGCT). Design The literature on the topic of MOGCT is reviewed, including pathology, prognostic factors, surgical strategies, postoperative therapy, late effects of therapy, and treatment of recurrence. Results Prognostic factors for MOGCT include the International Federation of Gynecology and Obstetrics staging system's stage, residual disease, histologic type, and elevation of serum tumor markers. Fertility-sparing surgery is possible in a large proportion of patients. The importance of comprehensive surgical staging is somewhat controversial. For patients with advanced-stage disease, maximum cytoreductive surgery appears to be beneficial. Although second-look surgery is not recommended routinely, selected patients may benefit from secondary cytoreduction. For those patients who require postoperative chemotherapy, standard therapy consists of the combination of bleomycin, etoposide, and cisplatin. However, there is a growing trend toward surveillance; this strategy continues to be studied. Although premature menopause may occur in a small proportion of patients, at least 80% of those who undergo fertility-sparing surgery and chemotherapy may expect to preserve reproductive function. For patients with early-stage disease, cure rates approach 100%. For those with advanced-stage disease, cure rates are reportedly at least 75%. Conclusion MOGCT is a rare malignancy that principally affects girls and young women. With optimal therapy, the prognosis is excellent, and most patients may retain reproductive function.

Fertility-Sparing Surgery Should Be the Standard Treatment in Patients with Malignant Ovarian Germ Cell Tumors

2017 ◽  
Vol 6 (2) ◽  
pp. 270-276 ◽  
Author(s):  
Osman Turkmen ◽  
Alper Karalok ◽  
Derman Basaran ◽  
Gunsu Comert Kimyon ◽  
Tolga Tasci ◽  
...  
Keyword(s):  
Germ Cell ◽  
Standard Treatment ◽  
Germ Cell Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing
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