scholarly journals Treatment outcomes in malignant ovarian germ cell tumors

2017 ◽  
Vol 6 (12) ◽  
pp. 5256
Author(s):  
Ram Kumar B.
Keyword(s):  
Germ Cell ◽  
Chemotherapy Regimen ◽  
Primordial Germ Cells ◽  
Germ Cell Tumour ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Germ Cell Tumours ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Yolk Sac Tumour

Background: Malignant ovarian germ cell tumours are rare group of ovarian neoplasms derived from primordial germ cells of the ovary. Objective of present study was to evaluate the outcome of treatment in malignant germ cell tumours.Methods: 21 Patients of malignant ovarian germ cell tumours registered at Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Chennai for the period from January 2012 to December 2015 were retrospectively analyzed for treatment outcomes.Results: The median age at presentation was 21 years with age range between 14 and 40 years. 9patients (43%) presented with mixed germ cell tumour, 6 patients (29%) with dysgerminoma, 3 patients (14%) with yolk sac tumour and 3 patients (14%)with mature cystic teratoma. 13 patients (62%) presented with Stage I disease, 5 patients (24%) with Stage III and 3 patients (14%) with Stage II. Fertility sparing surgery was done in 15 patients (71%), and 4 patients (19%) who completed family had TAH with BSO done. Adjuvant Chemotherapy was given for 16 patients (76%) and as Neoadjuvant in 2patients (10%) who had biopsy alone performed. 4patients (19%) developed recurrence and was taken for salvage PVI chemotherapy.Conclusions: Malignant ovarian germ cell tumours are relatively uncommon neoplasms characterized by high chemo sensitivity. This study confirms that malignant ovarian germ cell tumours have excellent prognosis and the effectiveness of BEP chemotherapy regimen. Fertility sparing surgery is feasible in most cases. Advanced Stage configured as an important risk factor for survival. The chemotherapy regimen was associated with significant but manageable toxicity.

Reproductive outcomes of fertility sparing surgeries in germ cell tumours

2017 ◽  
Vol 6 (2) ◽  
pp. 5266
Author(s):  
Ujwala Prakash Wakpaijan
Keyword(s):  
Overall Survival ◽  
General Population ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Young Patients ◽  
Age Group ◽  
Germ Cell Tumours ◽  
Reproductive Outcome ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

The main aim of the study is to observe the reproductive outcome in patient of germ cell tumour after fertility preserving surgery. In which retrospective records of patients diagnosed with malignant GCT in young patients treated with fertility sparing surgery and chemotherapy for ten years from 2000 to 2009. From the careful observations concluded the overall survival with the patients treated with fertility sparing surgery is excellent and the reproductive outcome is more or less equivalent to the general population of same age group.

scholarly journals Clinical presentation and management of malignant germ cell ovarian tumours in BPKMCH

2016 ◽  
Author(s):  
Jitendra Pariyar ◽  
Binuma Shrestha
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Germ Cell ◽  
Clinical Presentation ◽  
Early Stage ◽  
Germ Cell Tumour ◽  
Cystic Teratoma ◽  
Germ Cell Tumours ◽  
Early Stage Disease ◽  
Cancer Hospital ◽  
Disseminated Disease

Background: Germ cell malignancies account for about 5% of all ovarian cancers. These tumours grow rapidly and often produce symptoms quicker than the slow growing epithelial tumour. Commonly seen in the first two decades of life germ cell malignancies are highly chemosensitive and are potentially curable with surgery and chemotherapy. This study is the first of its kind regarding the epidemiology, management and outcome of patients with malignant germ cell tumour in Nepal. Objective: To analyze the clinical presentation and management outcomes of malignant germ cell tumours managed in B.P. Koirala Memorial Cancer Hospital, Nepal. Methodology: Descriptive study conducted in B.P. Koirala Memorial Cancer Hospital, Nepal. Case records of malignant germ cell tumours attending the hospital from January 1999 to December 2009 were analyzed regarding their illness history, clinical examination, investigations, treatment, follow-up and outcomes measured. Observations: Total 65 cases of malignant germ cell tumours with age range from 2 to 58 years (mean 21.7 years) were received. 42% cases were Tibeto-Burmese; 30% were Indo-Aryans. There were 15 cases (23%) of dysgeminoma, 21 endodermal sinus tumor (32%), 16 Immature Cystic Teratoma (24.5%), 9 (14%) Mixed Germ Cell, 2 unclassified GCT (3.5%) and 2 malignant transformation in teratoma (3.5%). 33 (49.5%) patients had early stage disease, 37 (57%) underwent fertility preserving surgery. 4 cases (9%) due to disseminated disease, underwent neoadjuvant chemotherapy followed by debulking surgery. 51 cases (78.5%) received adjuvant chemotherapy (BEP or EP regimen). The overall survival was 70%. Conclusion: Early stage germ cell malignancies can be safely managed by fertility preserving surgery followed by, chemotherapy if indicated. For advanced diseases, neoadjuvant chemotherapy followed by surgery can be undertaken with curable intent.

scholarly journals Yolk sac tumour of ovary with fever and overt hypothyroidism: rare clinical presentation

2020 ◽  
Vol 13 (1) ◽  
pp. e232114
Author(s):  
Megha Kansara ◽  
Garima Yadav ◽  
Meenakshi Gothwal ◽  
Pratibha Singh
Keyword(s):  
Germ Cell ◽  
Clinical Presentation ◽  
Early Stage ◽  
Yolk Sac ◽  
Gravid Uterus ◽  
Overt Hypothyroidism ◽  
Germ Cell Tumours ◽  
High Grade Fever ◽  
Fertility Sparing ◽  
Yolk Sac Tumour

Yolk sac tumours of the ovary are rare and highly malignant germ cell tumours, which comprise of only 10%–15% of all malignant germ cell tumours. They have various clinical presentations most common being subacute pelvic pain and feeling of lump but sometimes high-grade fever can be one of the rare presentations. Here, we present a case report of a 26-year-old nulliparous woman with 36 weeks gravid uterus size advanced stage yolk sac tumour of one ovary with fever as main clinical presentation and overt hypothyroidism. We did staging laparotomy with total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy with multiple peritoneal biopsies. Postoperatively, we had started adjuvant chemotherapy. Since yolk sac tumours are highly aggressive tumours as they rapidly increase in size, their early diagnosis and appropriate surgical management is required particularly in young women where fertility sparing surgery is possible in early stage with good prognosis.

scholarly journals Spectrum of ovarian tumors in a referral hospital in Nepal

2014 ◽  
Vol 4 (7) ◽  
pp. 539-543 ◽  
Author(s):  
S Vaidya ◽  
P Sharma ◽  
S KC ◽  
SA Vaidya
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Age Distribution ◽  
Germ Cell Tumors ◽  
Clinical Manifestations ◽  
Cystic Teratoma ◽  
Ovarian Tumors ◽  
Serous Carcinoma ◽  
Benign Tumors ◽  
Malignant Germ Cell Tumors

Background: Ovarian tumors are common forms of neoplasia in women. Among cancers of the female genital tract, it ranks only below carcinoma of the cervix and the endometrium, but is responsible for approximately 50% of the deaths. They arise from different cell lineages and hence constitute a wide variety of neoplastic entities with diverse morphological and clinical manifestations. Materials and Methods: A descriptive study of 363 cases of ovarian tumors was carried out during a three year period from January 2011 to December 2013. Results: Of the 363 ovarian tumors, 293 (80.72%) cases were benign, 57 (15.70%) were malignant and 13 (3.58%) were borderline. Germ cell tumour was the most common class of tumour and seen in 187 (51.52%) cases, followed by surface epithelial in 158 (43.53%) cases. The age distribution of the patients ranged from 10-82 years with a median age of 33 years. Benign tumors were more common than malignant ones in all age groups. Conclusion: Most of the ovarian tumors in this study were of germ cell origin. The incidence of malignant germ cell tumors was also significantly higher than in other studies. Mature cystic teratoma was the most common benign tumour while serous carcinoma was the most common malignancy. The incidence of malignant germ cell tumors was higher compared to other studies. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10295 Journal of Pathology of Nepal (2014) Vol. 4, 539-543

scholarly journals A study of ovarian tumors at Kathmandu medical college teaching hospital

2017 ◽  
Vol 7 (2) ◽  
pp. 1188-1191 ◽  
Author(s):  
Sailesh Bahadur Pradhan ◽  
Sanat Chalise ◽  
Binita Pradhan ◽  
Sailuja Maharjan
Keyword(s):  
Germ Cell ◽  
Hospital Admissions ◽  
Germ Cell Tumour ◽  
Malignant Neoplasm ◽  
Cystic Teratoma ◽  
College Teaching ◽  
Cell Tumour ◽  
Germ Cell Tumours ◽  
Cross Sectional ◽  
Epithelial Tumours

Background: Ovarian cysts, which present as neoplastic and non-neoplastic lesions, are the most common gynecological cause of hospital admissions. This study was conducted to know the spectrum of ovarian tumors.Materials and methods: A cross sectional study was carried out among all the ovarian specimens sent for histopathological examination.Results: Forty two cases were Surface epithelial tumours and 49 cases were germ cell tumour. Among Surface epithelial tumours, 34 (80.95%) were benign neoplasm, 2(4.76%) were borderline and 6 including one Krukenberg tumour (14.29%) were malignant neoplasm. Among all Germ cell tumours, 45 (91.84%) were Mature cystic teratoma, 1 (4.08%) was Immature cystic teratoma and 2 (4.08%) were Dysgerminoma. Conclusion: Incidence of Surface epithelial tumours and germ cell tumours were found to be almost equal with mild predominance of Germ cell tumour.

scholarly journals Fertility sparing surgery in malignant ovarian germ cell tumors (MOGCTs): 15 years experiences

2021 ◽  
Author(s):  
Shima Alizadeh ◽  
Narges Zamani ◽  
Mohadese Rezaei Poor ◽  
Sedigheh Ghasemian Dizajmehr ◽  
Mitra Modares Gilani
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

scholarly journals RARE CASES OF MIXED GERM CELL TUMOUR OF TESTIS- A REPORT OF TWO CASES WITH UNCOMMON COMBINATIONS AND REVIEW OF LITERATURE.

2021 ◽  
pp. 41-42
Author(s):  
Anshu Jamaiyar ◽  
Joyeeta Mandal ◽  
Anupriya Anupriya
Keyword(s):  
Germ Cell ◽  
Embryonal Carcinoma ◽  
Germ Cell Tumour ◽  
Immature Teratoma ◽  
Cell Tumour ◽  
Germ Cell Tumours ◽  
Review Of Literature ◽  
Different Types ◽  
Yolk Sac Tumour ◽  
Rare Category

Mixed germ cell tumours of testis represent a comparatively rare category of testicular tumour where different types of both seminomatous and non-seminomatous tumours can be present in varied proportions. We report two cases of mixed germ cell tumours, one consisting of seminoma, embryonal carcinoma and post-pubertal teratoma in the testis of a 22-year-old male and second consisting of a yolk sac tumour and immature teratoma in the testis of a 19-year-old male. We report theses case due to the rare combination and for documentation

Sign in / Sign up

Export Citation Format

Share Document