Anti-N-Methyl-D-Aspartate receptor encephalitis in a child

2021 ◽  
Author(s):  
Huu Son Nguyen
Keyword(s):  
Behavioral Problems ◽  
Pediatric Patients ◽  
Psychiatric Symptoms ◽  
Psychomotor Development ◽  
Behavioral Symptoms ◽  
Speech Impairment ◽  
Aspartate Receptor ◽  
And Behavior ◽  
Receptor Antibodies ◽  
Pediatric Center

Background: Anti-N-methyl-D-aspartate receptor encephalitis is a rare autoimmune disease characterized by severe neurological and psychiatric symptoms and difficult to diagnose. We report a case of Anti-N-methyl-D-aspartate receptor encephalitis diagnosed at the Pediatric Center of Hue Central Hospital. Case report: A 3½ - year - old girl with previously normal psychomotor development developed behavioral problems and speech impairment 2 week ago. From the onset of symptoms, choreic movements gradually appeared. Hematological, neuroradiological, and neurological examinations were negative; however, her symptoms worsened and treatment with methylprednisone was started. Although her choreic movements improved, her neuropsychological and behavioral symptoms still continued. Anti-N-methyl-Dspartate receptor antibodies in cerebrospinal fluid were detected. The second dose of methylprednisone and then immunoglobulins was administered. After several weeks of treatment, she was well recovered with a progressive improvement in language and behavior. Conclusions: Anti-N-methyl-D-aspartate receptor encephalitis in pediatric patients can present initially with neuropsychological and behavioral symptoms.

Human N-methyl-d-aspartate receptor antibodies alter memory and behavior in a passive ventricular murine infusion model

2014 ◽  
Vol 275 (1-2) ◽  
pp. 119
Author(s):  
Frank Leypoldt ◽  
Jesus Planaguma ◽  
Francesco Mannara ◽  
Javier Gutierrez Cuesta ◽  
Elena Martin-Garcia ◽  
...  
Keyword(s):  
Aspartate Receptor ◽  
And Behavior ◽  
Receptor Antibodies

scholarly journals Neuropsychological Evaluations in Limbic Encephalitis

2021 ◽  
Vol 11 (5) ◽  
pp. 576
Author(s):  
Juri-Alexander Witt ◽  
Christoph Helmstaedter
Keyword(s):  
Behavioral Problems ◽  
Limbic Encephalitis ◽  
Psychiatric Symptoms ◽  
Therapy Response ◽  
Long Term Memory ◽  
Evidence Based ◽  
Defect States ◽  
Neuropsychological Evaluations ◽  
And Behavior

Limbic encephalitis (LE) can cause dynamic and permanent impairment of cognition and behavior. In clinical practice, the question arises as to which cognitive and behavioral domains are affected by LE and which assessment is suited to monitor the disease progress and the success of treatment. Current findings on cognition and behavior in LE are reviewed and discussed based on current guidelines and consensus papers. In addition, we outline approaches for the neuropsychological monitoring of LE and its treatment. Dependent on disease acuity and severity, LE leads to episodic long-term memory dysfunction in different variants (e.g., anterograde memory impairment, accelerated long-term forgetting, and affection of autobiographical memory) and executive deficits. In addition, affective disorders are very common. More severe psychiatric symptoms may occur as well. In the course of the disease, dynamic phases with functional recovery must be differentiated from residual defect states. Evidence-based neuropsychological diagnostics should be conducted ideally before treatment initiation and reassessments are indicated when any progress is suggested, and when decisive anti-seizure or immunomodulatory treatment changes are made. Cognition and behavior may but must not run in synchrony with seizures, MRI pathology, or immune parameters. Cognitive and behavioral problems are integral aspects of LE and represent important biomarkers of disease acuity, progress, and therapy response beyond and in addition to parameters of immunology, neurological symptoms, and brain imaging. Thus, evidence-based neuropsychological assessments are essential for the diagnostic workup of patients with suspected or diagnosed limbic encephalitis, for treatment decisions, and disease and treatment monitoring.

scholarly journals Managing severe behavioral symptoms of a patient with anti-NMDAR encephalitis: case report and findings in current literature

2015 ◽  
Vol 37 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Vanina Lima Monteiro ◽  
Felipe José Nascimento Barreto ◽  
Paulo Marcos Brasil Rocha ◽  
Paulo Henrique Teixeira do Prado ◽  
Frederico Duarte Garcia ◽  
...  
Keyword(s):  
Psychiatric Symptoms ◽  
Behavioral Symptoms ◽  
Healthcare Team ◽  
Liaison Psychiatry ◽  
Neuropsychiatric Complications ◽  
Aspartate Receptor ◽  
Nmdar Encephalitis ◽  
Consultation Liaison Psychiatry ◽  
High Doses

Objective: Psychiatric symptoms emerge in the early stages of anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, and patients often seek treatment in psychiatric departments before visiting any other general medical services. Numerous articles about anti-NMDAR encephalitis have been published in the scientific community worldwide, but few emphasize the role of psychiatry in symptom management.Case description: We describe the case of a patient with anti- -NMDAR encephalitis seen in our service and discuss the management of behavioral symptoms based on current scientific literature. High doses of atypical antipsychotics and benzodiazepines were used to control agitation, and trazodone was administered to treat insomnia.Comments: Consultation-liaison psychiatry may help the healthcare team adjust the management of neuropsychiatric complications that might affect inpatients with anti-NMDAR encephalitis.

scholarly journals DDAA and Maternal Reflective Functions

2021 ◽  
Author(s):  
Alessandro Frolli ◽  
Antonella Cavallaro ◽  
Stephen Oduro ◽  
Antonia Bosco ◽  
Agnese Lombardi ◽  
...  
Keyword(s):  
Social Cognition ◽  
Parent Training ◽  
Old Age ◽  
School Children ◽  
Behavioral Problems ◽  
Behavioral Symptoms ◽  
Slight Reduction ◽  
Central Idea ◽  
Regulatory Functions ◽  
Age Range

AbstractIn this study, we propose to examine two types of Parent Training (PT) under DDAA —behavioral and reflective types of PT. The central idea of our work is that the development of parenting educational skills cannot ignore the development of reflective and regulatory functions, which promote pre-mentalization, social cognition, and empathic skills. Because of the lack of studies on the efficacy of behavioral PT addressed to the parents of subjects with DDAA, this work took place. This study included 90 families whose children were diagnosed with the disorder of dysregulated anger and aggression (DDAA) according to criteria of CD 0–5 (2016). The sample included pre-school children aged between 2 and 3 years old (age range 2–3 years), who were equally divided into two groups based on the type of PT administered to the parents or caregivers. Our results indicate that the PT intervention, which is focused on the improvement of parental reflexive functions, helps in obtaining greater results even in the reduction of the externalizing behavioral symptoms. Additionally, results show that the intervention of PT with a behavioral matrix does not improve parental reflexive functions even if it guarantees a slight reduction of children’s behavioral problems.

Pure ataxia associated with N-methyl-d-aspartate receptor antibodies

2014 ◽  
Vol 20 (5) ◽  
pp. 568-569 ◽  
Author(s):  
Diana Aguiar de Sousa ◽  
Patrícia Pita Lobo ◽  
Ana Castro Caldas ◽  
Miguel Coelho ◽  
Luísa Albuquerque
Keyword(s):  
Aspartate Receptor ◽  
Receptor Antibodies

WDR45 Gene and Its Role in Pediatric Epilepsies

2021 ◽  
Author(s):  
Federica Filosco ◽  
Sebastiano Billone ◽  
Ausilia Collotta ◽  
Tiziana Timpanaro ◽  
Monica Tosto ◽  
...  
Keyword(s):  
Language Impairment ◽  
Pediatric Patients ◽  
De Novo ◽  
Somatic Mosaicism ◽  
Brain Magnetic Resonance Imaging ◽  
Iron Accumulation ◽  
Psychomotor Development ◽  
Specific Gene ◽  
Brain Iron ◽  
De Novo Mutations

AbstractWD repeat domain 45 (WDR45) gene has been increasingly found in patients with developmental delay (DD) and epilepsy. Previously, WDR45 de novo mutations were reported in sporadic adult and pediatric patients presenting iron accumulation, while heterozygous mutations were associated with β-propeller protein-associated neurodegeneration (BPAN), a subtype of neurodegeneration with brain iron accumulation disorders, characterized by extrapyramidal movement disorders and abnormal accumulation of iron in the basal ganglia. Overall, people harboring WDR45 mutations have moderate to severe DD and different types of seizures. The phenotype of adult patients is characterized by extrapyramidal movement, dystonia, parkinsonism, language impairment, and involvement of the substantia nigra and in the globus pallidus at brain magnetic resonance imaging. Importantly, there are no findings of brain iron accumulation in brain in BPAN patients in the first decade of life, thus suggesting a progressive course of the disease. Comparatively, the main phenotype of pediatric patients is epilepsy with early onset, most of which present infantile spasms and arrest or regression of psychomotor development. The phenotype of patients with WDR45 mutations is variable, being different if caused by somatic mosaicism or germline mutations, and presenting with a different spectrum of manifestations in males and females. The treatment of affected individuals is symptomatic. Regarding the seizures, specific, gene-based approaches with specific antiepileptic drugs are not currently available. The early diagnosis of BPAN could be useful in some aspects, such as providing families a supportive treatment to their affected children.

585 The Relationship between Napping and Behavioral Problems among Vocational High School Students in China

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A231-A231
Author(s):  
Jing Han ◽  
Rendong Huang ◽  
Lei Yue ◽  
Naixue Cui ◽  
Fenglin Cao
Keyword(s):  
High School ◽  
High School Students ◽  
Behavior Problems ◽  
Behavioral Problems ◽  
Internalizing Behavior ◽  
Individual Development ◽  
Vocational High School ◽  
School Students ◽  
And Behavior ◽  
The Relationship

Abstract Introduction Although napping is very common and related to the outcome of individual development, the relationship between napping and health is not the same in different social and cultural contexts. In China, napping is considered as a healthy lifestyle and is often associated with better adolescent development outcomes. As a special group of teenagers (the academic level does not meet the requirements of ordinary high school), vocational high school students have a higher incidence of behavioral problems than ordinary high school students. Therefore, the purpose of this study is to explore the characteristics of napping and its relationship with behavioral problems in vocational high school students. Methods The napping questionnaire, Youth Self Report (YSR), general information questionnaire and other tools for covariates were used to measure 2505 high school students (62.04% boys, 37.96% girls, 16.71±0.02 years), recruited by convenient sampling. The relationship between nappingand behavioral problems was analyzed by multiple linear regression. Results 72.58% of the participants reported taking a midday nap at least three days per week during the past month, and 55.79% of our sample reported naps more than 30 minutes. Multiple regression analysis showed that nap frequency was negatively associated with high school students’ behavior problems after controlling for general characteristics and other important covariates. Compared with high school students who did not nap or napped less than 1 time/week, high school students who napped 1–2 times/week or 3–4 times/week had lower level of both internalizing behavior problems and externalizing behavior problems. There was no statistically significant association between nap duration and behavior problems. Conclusion This study finds that when napping is allowed, moderate frequency of napping is associated with lower level of internalizing and externalizing behavioral problems in vocational high school students, while nap duration is not significantly associated with behavioral problems. Further research is needed to explore the mechanism of the relationship between napping and behavior problems. Support (if any):

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