Nhiều ung thư nguyên phát trên một bệnh nhân

Journal of Clinical Medicine- Hue Central Hospital ◽

10.38103/jcmhch.2021.74.16 ◽

2021 ◽

Author(s):

Hoa Tran

Keyword(s):

Cancer Patients ◽

Relevant Literature ◽

Case Series ◽

Critical Factor ◽

Diagnostic Techniques ◽

Malignant Neoplasms ◽

Primary Malignancy ◽

Term Survival ◽

Multiple Primary ◽

Gynecologic Tumors

TÓM TẮT Đặt vấn đề: Bệnh cảnh một bệnh nhân mắc nhiều ung thư nguyên phát đã được coi là hiếm gặp, tuy nhiên trong thời gian gần đây cho thấy tần suất mắc bệnh nhiều ung thư nguyên phát (MPMN) trên một bệnh nhân ngày có xu hướng gia tăng. Qua 17 trường hợp được thông báo nhằm mục đích rút kinh nghiệm chẩn đoán để có hướng xử lý kịp thời và tốt hơn trong điều trị và tiên lượng; tạo điều kiện triển khai các nghiên cứu có giá trị hơn trong tương lai Báo cáo các trường hợp: Trong 17 trường hợp: 10 nữ và 7 nam: 4/17 (23,5%) MPMN cùng lúc, 13/17 (76,5%) MPMN phát triển sau đó. Hầu hết bệnh nhân trên 60 tuổi,các ung thư nguyên phát thứ 1 thường thấy ở các vị trí đường tiêu hóa: GIST 4/17 (23,5%) đại trực tràng 2/17 (11,8%), vú 6/17 (35,3%), phổi 2/117 (11,8 %) và ung thư thứ 2 và thứ 3 thường thấy ở đường tiêu hóa 6/17 (35,3 %), phụ khoa 5/17 (29,4%) vú 2/17 (11,8%) và phổi 3/17 (17,6%), 15/17 (88,2%) trường hợp mắc ung thư ở 2 vị trí và 2/17 (11,8 %) trường hơp mắc bệnh ở 3 vị trí. Kết luận: Bệnh cảnh mắc nhiều ung thư trên một bệnh nhân không còn là hiếm gặp. Việc chẩn đoán bệnh cần phải được lưu ý trong thời gian theo dõi bệnh. ABSTRACT A CASE SERIES OF MULTIPLE PRIMARY MALIGNANT NEOPLASMS Background: The development of improved diagnostic techniques, increased incidence of long term survival and life expectancy of cancer patients lead to the higher frequency of multiple primary malignant neoplasms (MPMN). This article aims to report series of cases our observed trend of increasing, in prevalence of both synchronously and metachronously second and third primary malignancy. Among the patients have been diagnosed with a cancer and reviewed in the relevant literature. Case series: Among 17 cases of MPMN that have been reported, 4/17 were synchronous (23.5%) and 13/17 were metachronous (76.5%), out of 17 patients, 10 were femals and 7 were males. The majority of the cases were over 60 years of age. In this report, the most common types of cancer were GIST (Stomach, Small intestine): 4/17 (23.5%); Breast: 6/17 (35.3%), Adenocarcinome of lung and colorectal: 2/17 (11.8%) as the first primary and Adenocarcinoma of gastrointestinal tract: 6/17 (35.3%), lung: 2/17 (11.8%), gynecologic tumors: 5/17 (29.4%), Breast: 2/17 (11.8%), lung: 3/17 (17,6%) as the second or the third primary cancer.Among 17 such patients, 15 and 2 primary malignant lessions occured at 2 sites and 3 sites respectively. Conclusion: The incidence of MPMN has not been rare at all. The diagnosis of MPMN should not be overlooked during follow - up. The doctor - patient relationship remains a critical factor in management. The clinicians should be aware of cases that cancer patients have metastasis in unusual sites and inconsistent clinical progression. Keywords: Multiple malignant neoplasms, primary.

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Multiple primary cancers: An enigma

South Asian Journal of Cancer ◽

10.4103/2278-330x.179698 ◽

2016 ◽

Vol 05 (01) ◽

pp. 29-32 ◽

Cited By ~ 15

Author(s):

Amitabh Jena ◽

Rashmi Patnayak ◽

Amancharla Yadagiri Lakshmi ◽

Banoth Manilal ◽

Mandyam Kumaraswamy Reddy

Keyword(s):

Cancer Patients ◽

Surgical Oncology ◽

Diagnostic Techniques ◽

Multiple Primary Cancers ◽

Primary Malignancy ◽

Term Survival ◽

Multiple Primary Malignancies ◽

Multiple Primary ◽

Synchronous Malignancies ◽

Age Range

Abstract Background: Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients. Materials and Methods: This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months. Results: A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma. Conclusion: Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.

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Rare heterochronous liver and pancreatic multiple primary cancers: a case report and literature review

Zeitschrift für Gastroenterologie ◽

10.1055/a-1160-6082 ◽

2020 ◽

Vol 58 (11) ◽

pp. 1094-1098

Author(s):

Wangjun Zhang ◽

Fan Xiao ◽

Jie Li ◽

Xiaoyu Guo ◽

Zhitao Lin ◽

...

Keyword(s):

Diagnostic Techniques ◽

Multiple Primary Cancers ◽

Second Primary ◽

Second Primary Malignancy ◽

Primary Malignancy ◽

Liver Malignancy ◽

Term Survival ◽

Pancreatic Cancers ◽

Multiple Primary ◽

Medical Diagnostic

AbstractIn recent years, with the continuous improvement of medical diagnostic techniques, the incidence of multiple primary carcinoma (MPC) has increased gradually. Elderly patients are at high risk of MPC. However, the risk of developing a second primary malignancy is 1 % for primary liver malignancy 1. The risk of pancreatic cancers as secondary malignancies with primary liver malignancy is very rare. Here, we report a rare case of heterochronous liver and pancreatic MPCs and review the related literature. We report this case to raise the clinician’s attention to the disease because the long-term survival rate can be effectively improved by timely diagnosis and appropriate treatment. For patients with HCV-positive primary cancers, active antiviral therapy should be simultaneously provided with antitumor therapy, thereby effectively reducing the incidence of MPC.

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Involvement of the genitourinary system in multiple primary malignant neoplasms: a review.

Journal of Clinical Oncology ◽

10.1200/jco.1983.1.9.574 ◽

1983 ◽

Vol 1 (9) ◽

pp. 574-581 ◽

Cited By ~ 30

Author(s):

P Ray ◽

R Sharifi ◽

V Ortolano ◽

P Guinan

Keyword(s):

Cancer Patients ◽

Malignant Neoplasms ◽

Genitourinary System ◽

Multiple Primary

A case is presented of a patient with separate primaries of the cervix, breast, bladder, and kidney. In a review of 352,073 cancer patients in the literature, the genitourinary system appears to be at a greater risk of this phenomenon. The entity of multiple primary malignant neoplasms is reviewed with an analysis of the involvement of the genitourinary system.

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Metachronous Multiple Primary Malignant Neoplasms of the Stomach and the Breast: Report of Two Cases With Review of Literature

International Surgery ◽

10.9738/intsurg-d-13-00056.1 ◽

2014 ◽

Vol 99 (1) ◽

pp. 52-55 ◽

Cited By ~ 4

Author(s):

Vilvapathy Senguttuvan Karthikeyan ◽

Sarath Chandra Sistla ◽

Ramachandran Srinivasan ◽

Debdatta Basu ◽

Lakshmi C. Panicker ◽

...

Keyword(s):

Malignant Neoplasm ◽

Second Primary ◽

Malignant Neoplasms ◽

Rare Occurrence ◽

Review Of Literature ◽

Second Primary Malignancy ◽

Carcinoma Of The Breast ◽

Primary Malignancy ◽

Multiple Primary ◽

Second Primary Malignancies

Abstract Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly.

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A case series report of cancer patients undergoing group body psychotherapy

F1000Research ◽

10.12688/f1000research.12262.2 ◽

2018 ◽

Vol 6 ◽

pp. 1646

Author(s):

Astrid Grossert ◽

Gunther Meinlschmidt ◽

Rainer Schaefert

Keyword(s):

Cancer Patients ◽

Case Series ◽

Patient Reported Outcome ◽

Unintended Consequences ◽

Post Treatment ◽

Malignant Neoplasms ◽

Oncological Treatment ◽

Body Psychotherapy ◽

Outpatient Group ◽

Patient Reported

Background: Disturbances in bodily wellbeing represent a key source of psychosocial suffering and impairment related to cancer. Therefore, interventions to improve bodily wellbeing in post-treatment cancer patients are of paramount importance. Notably, body psychotherapy (BPT) has been shown to improve bodily wellbeing in subjects suffering from a variety of mental disorders. However, how post-treatment cancer patients perceive and subjectively react to group BPT aiming at improving bodily disturbances has, to the best of our knowledge, not yet been described. Methods: We report on six patients undergoing outpatient group BPT that followed oncological treatment for malignant neoplasms. The BPT consisted of six sessions based on a scientific embodiment approach, integrating body-oriented techniques to improve patients’ awareness, perception, acceptance, and expression regarding their body. Results: The BPT was well accepted by all patients. Despite having undergone different types of oncological treatment for different cancer types and locations, all subjects reported having appreciated BPT and improved how they perceived their bodies. However, individual descriptions of improvements showed substantial heterogeneity across subjects. Notably, most patients indicated that sensations, perceptions, and other mental activities related to their own body intensified when proceeding through the group BPT sessions. Conclusion: The findings from this case series encourage and inform future studies examining whether group BPT is efficacious in post-treatment cancer patients and investigating the related mechanisms of action. The observed heterogeneity in individual descriptions of perceived treatment effects point to the need for selecting comprehensive indicators of changes in disturbances of bodily wellbeing as the primary patient-reported outcome in future clinical trials. While increases in mental activities related to their own body are commonly interpreted as important mechanisms of therapeutic action in BPT, follow-up assessments are needed to evaluate intended and unintended consequences of these changes in cancer patients.

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Clinical Features and Outcome of Thrombotic Microangiopathies: Comparison between Patients with and without Malignancy

Thrombosis and Haemostasis ◽

10.1055/s-0040-1720974 ◽

2020 ◽

Author(s):

Andry Van de Louw ◽

Austin Cohrs ◽

Douglas Leslie

Keyword(s):

Hospital Mortality ◽

Cancer Patients ◽

Case Series ◽

Large Data ◽

Sensitivity Analyses ◽

Cell Transplant ◽

Term Survival ◽

Hematopoietic Stem ◽

Long Term Survival

AbstractThrombotic microangiopathy (TMA) is an uncommon complication of cancers, related to the malignancy itself, antineoplastic drugs, or hematopoietic stem cell transplant. It was reported mostly as case series but large data are lacking. We used the large U.S. MarketScan database to compare TMA between patients with and without malignancy. Adult patients hospitalized between 2005 and 2014 with a diagnosis of TMA were included; cancer patients were defined by a diagnosis of cancer within 1 year prior to or during the admission with TMA. Associated inpatient diagnoses, procedures, hospital mortality, and long-term survival were collected. We included 3,227 patients; 617 (19.1%) had cancer (age 54 [44–60] years, 58% female), which was a new diagnosis for 23% of patients. Two-thirds of cancer patients had solid tumors (mostly pancreas, lung, breast, colorectal, and hepatobiliary, half of them metastatic) and one-third had hematological malignancies (lymphoma, acute leukemia, and multiple myeloma); TMA patients with cancer were older, more often men, had more noncancer-related comorbidities, and developed more sepsis and coagulopathy than TMA patients without cancer. Hospital mortality was significantly higher in cancer patients (16.6% vs. 6.1%, p < 0.001) and reached 30% in transplant recipients; malignancy was an independent risk factor for hospital mortality in multivariate analysis and sensitivity analyses excluding patients with metastases or patients who did not undergo plasmapheresis led to similar results. Malignancy was also associated with decreased long-term survival.

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Propensity score matching analysis of ovarian cancer patients with multiple primary malignant neoplasms using multicenter real-world data.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e17501 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e17501-e17501

Author(s):

Qing-lei Gao ◽

Xiaofei Jiao ◽

Ruyuan Li ◽

Shaoqing Zeng ◽

Yingjun Zhao ◽

...

Keyword(s):

Breast Cancer ◽

Ovarian Cancer ◽

Overall Survival ◽

Propensity Score ◽

Propensity Score Matching ◽

Cancer Patients ◽

Cox Regression ◽

Malignant Neoplasms ◽

Cox Regression Analysis ◽

Multiple Primary

e17501 Background: Multiple primary malignant neoplasms (MPMNs) in patients with ovarian cancer is rare and has not attracted enough attention. It is unclear how the MPMNs affect the prognosis of ovarian cancer (OC) patients. Methods: This is a multicenter retrospective analysis of 5, 268 ovarian cancer patients from six centers who was diagnosed with ovarian cancer from January 1, 1989 to August 21, 2020. Propensity score matching was used to balance the baseline characteristics between patients with and without MPMNs. Cox regression analysis was utilized to analyze the influence of MPMNs on overall survival (OS). Results: After excluding unqualified medical record, totally 4, 848 patients were analyzed and 240 were concurrent at least one MPMNs other than OC. Ten patients had two MPMNs and one patient had three. The most common concurrent cancer was breast cancer (111/240, 46.25%), followed by endometrial cancer (37/240, 15.42%), and cervical cancer (30/240, 12.50%). Patients with MPMNs were elder than those without MPMNs (52 vs. 51, P = 0.03) when ovarian cancer was diagnosed. And the proportion of early-stage cases was lower in patients with MPMNs (25.8% vs. 27.2%, P < 0.001). Patients with breast cancer had a higher proportion of high-grade serous ovarian cancer (HGSOC) than those without MPMNs. After using the propensity score matching method adjusting age, pathological type, grade, and stage, concurrent MPMNs, including breast cancer, had no effect on OS of ovarian cancer patients. Among 240 patients with MPMNs, patients with breast cancer shared similar age and stage compared with the rest patients, while their proportion of HGSOC was higher than patients with other cancer (68.4% vs. 51.1%, P = 0.028). However, the median OS of those two groups were similar (27.3 m vs.27.1 m, P = 0.744). In addition, 94 patients were diagnosed with breast cancer prior to ovarian cancer, seven diagnosed posteriorly to ovarian cancer, four diagnosed simultaneously, and six had no precise diagnosed dates. There was no remarkable difference in clinical characteristics between the prior and posterior groups, however, the median OS of those seven patients was significantly longer than the prior group (76.0 m vs. 25.4 m, P = 0.002). Conclusions: The MPMNs showed no influence on the overall survival of ovarian cancer patients. The order of diagnosis of ovarian cancer and breast cancer might affect the prognosis.

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