scholarly journals Multiple primary cancers: An enigma

2016 ◽  
Vol 05 (01) ◽  
pp. 29-32 ◽  
Author(s):  
Amitabh Jena ◽  
Rashmi Patnayak ◽  
Amancharla Yadagiri Lakshmi ◽  
Banoth Manilal ◽  
Mandyam Kumaraswamy Reddy
Keyword(s):  
Cancer Patients ◽  
Surgical Oncology ◽  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Primary Malignancy ◽  
Term Survival ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Synchronous Malignancies ◽  
Age Range

Abstract Background: Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients. Materials and Methods: This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months. Results: A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma. Conclusion: Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.

Rare heterochronous liver and pancreatic multiple primary cancers: a case report and literature review

2020 ◽  
Vol 58 (11) ◽  
pp. 1094-1098
Author(s):  
Wangjun Zhang ◽  
Fan Xiao ◽  
Jie Li ◽  
Xiaoyu Guo ◽  
Zhitao Lin ◽  
...  
Keyword(s):  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Liver Malignancy ◽  
Term Survival ◽  
Pancreatic Cancers ◽  
Multiple Primary ◽  
Medical Diagnostic

AbstractIn recent years, with the continuous improvement of medical diagnostic techniques, the incidence of multiple primary carcinoma (MPC) has increased gradually. Elderly patients are at high risk of MPC. However, the risk of developing a second primary malignancy is 1 % for primary liver malignancy 1. The risk of pancreatic cancers as secondary malignancies with primary liver malignancy is very rare. Here, we report a rare case of heterochronous liver and pancreatic MPCs and review the related literature. We report this case to raise the clinician’s attention to the disease because the long-term survival rate can be effectively improved by timely diagnosis and appropriate treatment. For patients with HCV-positive primary cancers, active antiviral therapy should be simultaneously provided with antitumor therapy, thereby effectively reducing the incidence of MPC.

Nhiều ung thư nguyên phát trên một bệnh nhân

2021 ◽  
Author(s):  
Hoa Tran
Keyword(s):  
Cancer Patients ◽  
Relevant Literature ◽  
Case Series ◽  
Critical Factor ◽  
Diagnostic Techniques ◽  
Malignant Neoplasms ◽  
Primary Malignancy ◽  
Term Survival ◽  
Multiple Primary ◽  
Gynecologic Tumors

TÓM TẮT Đặt vấn đề: Bệnh cảnh một bệnh nhân mắc nhiều ung thư nguyên phát đã được coi là hiếm gặp, tuy nhiên trong thời gian gần đây cho thấy tần suất mắc bệnh nhiều ung thư nguyên phát (MPMN) trên một bệnh nhân ngày có xu hướng gia tăng. Qua 17 trường hợp được thông báo nhằm mục đích rút kinh nghiệm chẩn đoán để có hướng xử lý kịp thời và tốt hơn trong điều trị và tiên lượng; tạo điều kiện triển khai các nghiên cứu có giá trị hơn trong tương lai Báo cáo các trường hợp: Trong 17 trường hợp: 10 nữ và 7 nam: 4/17 (23,5%) MPMN cùng lúc, 13/17 (76,5%) MPMN phát triển sau đó. Hầu hết bệnh nhân trên 60 tuổi,các ung thư nguyên phát thứ 1 thường thấy ở các vị trí đường tiêu hóa: GIST 4/17 (23,5%) đại trực tràng 2/17 (11,8%), vú 6/17 (35,3%), phổi 2/117 (11,8 %) và ung thư thứ 2 và thứ 3 thường thấy ở đường tiêu hóa 6/17 (35,3 %), phụ khoa 5/17 (29,4%) vú 2/17 (11,8%) và phổi 3/17 (17,6%), 15/17 (88,2%) trường hợp mắc ung thư ở 2 vị trí và 2/17 (11,8 %) trường hơp mắc bệnh ở 3 vị trí. Kết luận: Bệnh cảnh mắc nhiều ung thư trên một bệnh nhân không còn là hiếm gặp. Việc chẩn đoán bệnh cần phải được lưu ý trong thời gian theo dõi bệnh. ABSTRACT A CASE SERIES OF MULTIPLE PRIMARY MALIGNANT NEOPLASMS Background: The development of improved diagnostic techniques, increased incidence of long term survival and life expectancy of cancer patients lead to the higher frequency of multiple primary malignant neoplasms (MPMN). This article aims to report series of cases our observed trend of increasing, in prevalence of both synchronously and metachronously second and third primary malignancy. Among the patients have been diagnosed with a cancer and reviewed in the relevant literature. Case series: Among 17 cases of MPMN that have been reported, 4/17 were synchronous (23.5%) and 13/17 were metachronous (76.5%), out of 17 patients, 10 were femals and 7 were males. The majority of the cases were over 60 years of age. In this report, the most common types of cancer were GIST (Stomach, Small intestine): 4/17 (23.5%); Breast: 6/17 (35.3%), Adenocarcinome of lung and colorectal: 2/17 (11.8%) as the first primary and Adenocarcinoma of gastrointestinal tract: 6/17 (35.3%), lung: 2/17 (11.8%), gynecologic tumors: 5/17 (29.4%), Breast: 2/17 (11.8%), lung: 3/17 (17,6%) as the second or the third primary cancer.Among 17 such patients, 15 and 2 primary malignant lessions occured at 2 sites and 3 sites respectively. Conclusion: The incidence of MPMN has not been rare at all. The diagnosis of MPMN should not be overlooked during follow - up. The doctor - patient relationship remains a critical factor in management. The clinicians should be aware of cases that cancer patients have metastasis in unusual sites and inconsistent clinical progression. Keywords: Multiple malignant neoplasms, primary.

scholarly journals Double synchronous primary gastric and thyroid cancer

2020 ◽  
Vol 7 (8) ◽  
pp. 2728
Author(s):  
Abdulhakeem Almasood ◽  
Mohammed Hussain ◽  
Mohammed Aljabali ◽  
Bandar Idrees Ali
Keyword(s):  
Thyroid Gland ◽  
Diagnostic Techniques ◽  
Multiple Primary Cancers ◽  
Invasive Adenocarcinoma ◽  
Primary Tumors ◽  
Cancer Of The Stomach ◽  
Multiple Primary Malignancies ◽  
Number Of Patients ◽  
Short Period ◽  
Multiple Primary

Second or multiple primary malignancies is very rare and the number of patients diagnosed with multiple primary cancers has recently been increasing due to the improved diagnostic techniques. Herein we report a very rare case of synchronous double primary cancer of the stomach and thyroid gland for the 39 years old lady who presented with a short period of abdominal pain were diagnosed to have an invasive adenocarcinoma with signet ring differentiation of the stomach by gastroscopy and biopsy. Computed tomography and positron emission tomography scan showed high fludeoxyglucose uptake of the thyroid gland were biopsied to confirm the malignancy. underwent initially for radical distal gastrectomy followed by adjuvant chemotherapy and interval total thyroidectomy. Although Synchronous tumors are defined as ≥2 primary tumors occurring within 6 months of diagnosis of the first primary tumor, our case was discovered concomitantly at the first presentation of the patient. The prognosis of patients with multiple primary cancers can be determined independently by the stage of each cancer.

Inherited mutations in breast cancer patients with and without multiple primary cancers.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 1503-1503
Author(s):  
Kara Noelle Maxwell ◽  
Joseph Vijai ◽  
Jenna Lilyquist ◽  
Thomas Paul Slavin ◽  
Abha Kulkarni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Multiple Primary Cancers ◽  
Breast Cancer Patients ◽  
Multiple Primary ◽  
Inherited Mutations

Esophageal Cancer Associated with Multiple Primary Cancers: Surgical Approaches and Long-term Survival

2013 ◽  
Vol 20 (13) ◽  
pp. 4260-4266 ◽  
Author(s):  
Geun Dong Lee ◽  
Yong-Hee Kim ◽  
Joon Bum Kim ◽  
Se Hoon Choi ◽  
Hyeong Ryul Kim ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Surgical Approaches ◽  
Multiple Primary Cancers ◽  
Term Survival ◽  
Long Term Survival ◽  
Multiple Primary

scholarly journals Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Michele L. Santangelo ◽  
Carmen Criscitiello ◽  
Andrea Renda ◽  
Stefano Federico ◽  
Giuseppe Curigliano ◽  
...  
Keyword(s):  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Predisposing Factor ◽  
Multiple Cancers ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Second Tumor ◽  
Tumor Types

Immunodeficiency is associated with higher cancer incidence. However, it is unknown whether there is a link between immunodeficiency and development of multiple primary malignancies. In the present study we analyse this link focusing on kidney-transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppressants. We followed up 1200 patients who underwent kidney transplantation between 1980 and 2012. A total of 77/1200 kidney-transplanted patients developed cancer and 24 of them developed multiple cancers. Most multiple cancers were synchronous with a nonsignificant association between cancer and rejection episodes. In the general cancer population, one-ninth of patients are at higher risk of developing a second tumor over a lifetime; hence it would be reasonable to conclude that, from a merely theoretical and statistical viewpoint, long-term transplanted patients potentially have a higher risk of developing MPMs. However, data did not confirm this assumption, probably because these patients die before a second primary malignancy appears. Despite many observations on the increased incidence of different tumor types in immunodeficient patients and despite immunosuppression certainly being a predisposing factor for the multicancer syndrome, data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients.

scholarly journals Multiple primary cancers among lung or laryngeal cancer patients.

1988 ◽  
Vol 39 (2) ◽  
pp. 113-119
Author(s):  
Shaw Watanabe ◽  
Yumiko Kobayashi ◽  
Isamu Ono
Keyword(s):  
Cancer Patients ◽  
Laryngeal Cancer ◽  
Multiple Primary Cancers ◽  
Multiple Primary

scholarly journals Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and 2018

2020 ◽  
Vol 184 (1) ◽  
pp. 221-228
Author(s):  
Jenny Nyqvist ◽  
Toshima Z. Parris ◽  
Khalil Helou ◽  
Elisabeth Kenne Sarenmalm ◽  
Zakaria Einbeigi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Registry ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Gastrointestinal Malignancies ◽  
Screening Programs ◽  
Multiple Primary Malignancies ◽  
Multiple Primary ◽  
Swedish Cancer Registry

Abstract Purpose Multiple primary malignancies (MPMs) caused by breast cancer treatment are well described, but only few studies to date describe which other previous primary malignancies (OPPMs) occur before breast cancer. The purpose of the present study was to evaluate the prevalence of OPPMs in patients with breast cancer between 2007 and 2018 in Western Sweden. Methods Patient selection was performed using both pathology reports at Sahlgrenska University Hospital (Sweden) and the Swedish Cancer Registry. All newly diagnosed breast cancer patients were screened for presence of OPPM. Results In total, 8031 breast cancer patients were diagnosed at Sahlgrenska University Hospital between 2007 and 2018. The prevalence of breast cancer patients with OPPMs (n = 414) increased from on average 2.6% to 8.2% during this 12-year period and ranged from 17 to 59 patients annually. The most striking increase in prevalence was found among the gynecological tumors (endometrium and ovarian adenocarcinomas), malignant melanomas and gastrointestinal malignancies. These findings were validated using data of the Swedish Cancer Registry. Conclusions The overall survival rates for cancer patients have improved tremendously during the past 40 years, in part due to individually tailored therapies and screening programs. Our study revealed an increasing trend of OPPMs in breast cancer patients.

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