scholarly journals FORMULATION, DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHES OF ANTIPSYCHOTIC DRUG OLANZAPINE

2021 ◽  
Vol 10 (4) ◽  
pp. 101
Author(s):  
Sailesh Kumar Ghatuary ◽  
Abhishek Kumar ◽  
Satkar Prasad ◽  
Kalpana Badoniya
Keyword(s):  
Antipsychotic Drug ◽  
Formulation Development ◽  
Transdermal Patches

scholarly journals Transdermal patches: Design and current approaches to painless drug delivery

2019 ◽  
Vol 69 (2) ◽  
pp. 197-215 ◽  
Author(s):  
Othman A. Al Hanbali ◽  
Haji Muhammad Shoaib Khan ◽  
Muhammad Sarfraz ◽  
Mosab Arafat ◽  
Shakeel Ijaz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Hepatic Metabolism ◽  
Enzymatic Digestion ◽  
Assessment Tools ◽  
Oral Drug ◽  
Formulation Development ◽  
Transdermal Patches ◽  
Cardiac Disorders

Abstract Use of transdermal patches can evade many issues associated with oral drug delivery, such as first-pass hepatic metabolism, enzymatic digestion attack, drug hydrolysis and degradation in acidic media, drug fluctuations, and gastrointestinal irritation. This article reviews various transdermal patches available in the market, types, structural components, polymer role, and the required assessment tools. Although transdermal patches have medical applications for smoking cessation, pain relief, osteoporosis, contraception, motion sickness, angina pectoris, and cardiac disorders, advances in formulation development are ongoing to make transdermal patches capable of delivering more challenging drugs. Transdermal patches can be tailored and developed according to the physicochemical properties of active and inactive components, and applicability for long-term use. Therefore, a number of chemical approaches and physical techniques for transdermal patch development are under investigation.

Formulation development of matrix type transdermal patches containing mefenamic acid: physicochemical characterization and in vitro release evaluation

2017 ◽  
Vol 148 (7) ◽  
pp. 1215-1222 ◽  
Author(s):  
Jirapornchai Suksaeree ◽  
Kotchakorn Piamsap ◽  
Supawan Paktham ◽  
Tichakorn Kenprom ◽  
Chaowalit Monton ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
In Vitro Release ◽  
Physicochemical Characterization ◽  
Formulation Development ◽  
Matrix Type ◽  
Transdermal Patches ◽  
Vitro Release

scholarly journals Formulation development and investigation of domperidone transdermal patches

2011 ◽  
Vol 1 (4) ◽  
pp. 240 ◽  
Author(s):  
Samip Shah ◽  
Prabhakar Prabhu ◽  
Shankar Gundad
Keyword(s):  
Formulation Development ◽  
Transdermal Patches

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF CLOZAPINE TRANSDERMAL PATCHES

2021 ◽  
pp. 204-207
Author(s):  
Pratik P. Patel ◽  
Priyal M. Raval
Keyword(s):  
Clinical Study ◽  
Schizoaffective Disorder ◽  
Suicidal Behaviour ◽  
Therapeutic Interventions ◽  
Positive Symptoms ◽  
Keywords Schizophrenia ◽  
Formulation Development ◽  
Transdermal Patches ◽  
Experimental Process ◽  
Second Generation Antipsychotic

The Clozapine is available in the form of 25 Yellow Tablets of 100mg. Clozapine is very famous in now-a-days due to its use of optimisation in transdermal metric basically for experimental process and design.it is used for the improvement of bioavailability. The medications are demonstrated for mitigating the risk of recurrent suicidal behaviour in schizophrenia patients or schizoaffective disorder who really are evaluated to be at persistent risk of convolutional suicidal behaviour in a historical and controlled experimental state. The paper provides a brief analysis of Clozapine drugs Usage, Formulation and Evaluation. The drugs were used upon animals at first to test the effects. There are several side effects of Clozapine that includes High fever and also symptoms like flu, Weakness and dizziness, allergy in skin and red spots, Sometimes itching problems in vaginal, in serious problems it can also create breathing problems and worsening cough. This is known as the Second Generation Antipsychotic that helps in balancing the dopamine and serotonin that improves the cognitive functions like mood, thinking and behaviour of an individual. Clozapine is restricted to use however it is used under one particular condition i.e. when the person suffering from Schizophrenia does not respond to other medications, have suicidal incidents or have positive symptoms. Furthermore, considerable clinical study has proven that clozapine seems to be more efficacious than just about any other antipsychotic drug throughout therapeutic interventions and therefore it clearly outperforms some other antipsychotics with in treatment of recurrent schizoaffective disorder. KEYWORDS: schizophrenia, transdermal, clozapine, antipsychotic

scholarly journals FORMULATION DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCHES OF FENOPROFEN

2021 ◽  
Vol 10 (4) ◽  
pp. 109
Author(s):  
Murli Anon ◽  
Kaushelendra Mishra ◽  
A. K. Singhai ◽  
Prabhat Jain
Keyword(s):  
Formulation Development ◽  
Transdermal Patches

scholarly journals Novel insight into Potential Leishmanicidal Activities of Transdermal Patches of Nigella Sativa: Formulation Development, Physical Characterizations and In vitro In vivo Assays

2021 ◽  
Author(s):  
Barkat Ali Khan ◽  
Yasmin Asmat ◽  
Tariq Hayat Khan ◽  
Mughal Qayum ◽  
Sultan Muhammad Alshahrani ◽  
...  
Keyword(s):  
Drug Release ◽  
Nigella Sativa ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
Formulation Development ◽  
Standard Drug ◽  
Drug Permeation ◽  
Transdermal Patches

Abstract Cutaneous Leishmaniasis (CL) is the most common type of Leishmaniasis which annually affects 1.5 million people worldwide. About 90% of cases are reported from countries such as Iran, Afghanistan, Pakistan, Iraq, and Saudi Arabia. The purpose of the present study was to fabricate transdermal patches of Nigella sativa (NS), characterize and to check its in vitro in vivo anti-Lieshmanial activity. Hydroalcohlic extract was analyzed for preliminary phytochemicals. Five formulations of transdermal patches (NS1, NS2, NS3, NS4 and NS5) were prepared by solvent evaporation method. The optimized formulation NS5 was characterized for FTIR, smoothness, brittleness, clarity, thickness, folding endurance, uniformity of weight, percent moisture content, in-vitro drug release, release kinetics, ex vivo drug permeation and in-vitro anti-Lieshmanial activity. In vivo anti-Lieshmanial activity was assessed in 30 patients (n = 30) suffering from CL. The FTIR studies showed no incompatibility among the active extract and polymers. In vitro anti-Lieshmanial assay was 194.6 ± 1.88 % as compared to standard drug (p > 0.05) and in vivo anti-Lieshmanial activity was 75 %. The drug release after 24 hours was 87.0 ± 0.94% in NS5 which showed non-Fickian diffusion mechanism while drug permeation across rabbit skin after 24 hours was up to 80.0 ± 0.91%. The results concluded that problems related to the medications parenterally used for Lieshmanial treatment can be managed by applying extract of Nigella sativa seeds in the form of transdermal patch.

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