IL-17A in COVID-19 Cases: a meta-analysis

Introduction: Numerous reviews, commentaries and opinion pieces have suggested targeting IL-17A as part of managing Coronavirus disease 2019 (COVID-19), the notorious pandemic caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IL-17A is a proinflammatory cytokine attributed with homeostatic roles but that is also involved in autoimmune disease pathogenesis. While some studies have reported an increase in IL-17A in COVID-19 cases, no significant associations were found by others. Hence, we undertook this meta-analysis to study serum IL-17A levels in COVID-19 patients in relation to disease severity. Methodology: Multiple databases were systematically reviewed for literature published on the topic from January 1, 2019 to April 30, 2021. A random effects model was used to calculate weighted mean differences (WMDs) and 95% confidence interval (CIs) as well as the

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Exploring the Relationships Between Problem Gambling and ADHD: A Meta-Analysis

Journal of Attention Disorders ◽

10.1177/1087054715626512 ◽

2016 ◽

Vol 23 (12) ◽

pp. 1427-1437 ◽

Cited By ~ 8

Author(s):

Jennifer Theule ◽

Kylee E. Hurl ◽

Kristene Cheung ◽

Michelle Ward ◽

Brenna Henrikson

Keyword(s):

Confidence Interval ◽

Problem Gambling ◽

Random Effects ◽

Meta Analysis ◽

Random Effects Model ◽

Adhd Symptoms ◽

Weighted Mean ◽

Problem Gamblers ◽

Gambling Severity ◽

Meta Analyses

Objective: At present, there are inconsistencies in the literature pertaining to the association between ADHD and problem gambling. This study utilized meta-analytic techniques to clarify the association between symptoms of problem gambling and symptoms of ADHD. Method: Several meta-analyses were conducted using a random effects model. PsycINFO, PubMed, ProQuest Dissertations & Theses, and Google Scholar were searched for relevant studies. Results: The weighted mean correlation between ADHD symptomology and gambling severity was r = .17, 95% confidence interval (CI) = [0.12, 0.22], p < .001. Mean age of the sample was the only moderator to approach significance, with greater age being linked to a stronger relationship between symptoms of ADHD and gambling severity. Conclusion: Clinicians needs to be cognizant of the greater risk of ADHD symptoms when working with problem gamblers and vice versa.

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Effects of Quercetin Supplementation on Endurance Performance and Maximal Oxygen Consumption: A Meta-Analysis

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.23.1.73 ◽

2013 ◽

Vol 23 (1) ◽

pp. 73-82 ◽

Cited By ~ 16

Author(s):

Denis M. Pelletier ◽

Guillaume Lacerte ◽

Eric D.B. Goulet

Keyword(s):

Oxygen Consumption ◽

Random Effects ◽

Meta Analysis ◽

Maximal Oxygen Consumption ◽

Daily Intake ◽

Endurance Performance ◽

Mixed Effects ◽

Random Effects Model ◽

Weighted Mean ◽

Meta Regression

Lately, the effect of quercetin supplementation (QS) on endurance performance (EP) and maximal oxygen consumption (VO2max) has been receiving much scientific and media attention. Therefore, a meta-analysis was performed to determine QS’s ergogenic value on these variables. Studies were located with database searches (PubMed and SPORTDiscus) and cross-referencing. Outcomes represent mean percentage changes in EP (measured via power output) and VO2max between QS and placebo. Random-effects model meta-regression, mixed-effects model analog to the ANOVA, random-effects weighted mean effect summary, and magnitudebased inferences analyses were used to delineate the effects of QS. Seven research articles (representing 288 subjects) were included, producing 4 VO2max and 10 EP effect estimates. Mean QS daily intake and duration were, respectively, 960 ± 127 mg and 26 ± 24 d for the EP outcome and 1,000 ± 0 mg and 8 ± 23 d for the VO2max outcome. EP was assessed during exercise with a mean duration of 79 ± 82 min. Overall, QS improved EP by 0.74% (95% CI: 0.10–1.39, p = .02) compared with placebo. However, only in untrained individuals (0.83% ± 0.78%, p = .02) did QS significantly improve EP (trained individuals: 0.09% ± 2.15%, p = .92). There was no relationship between QS duration and EP (p = .69). Overall, QS increased VO2max by 1.94% (95% CI: 0.30–3.59, p = .02). Magnitude-based inferences suggest that the effect of QS on EP and VO2max is likely to be trivial for both trained and untrained individuals. In conclusion, this meta-analysis indicates that QS is unlikely to prove ergogenic for aerobic-oriented exercises in trained and untrained individuals.

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325The incidence of primary postpartum haemorrhage following in-hospital birth: a systematic review and meta-analysis

International Journal of Epidemiology ◽

10.1093/ije/dyab168.661 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Bewket Tadesse Tiruneh ◽

Gayle McLelland ◽

Virginia Plummer

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Random Effects ◽

Postpartum Haemorrhage ◽

Meta Analysis ◽

Random Effects Model ◽

Preventive Strategies ◽

Heterogeneity Test ◽

Ovid Medline ◽

Hospital Births

Abstract Background Although primary postpartum haemorrhage is a leading cause of maternal mortality, in the wider literature, there is inconsistent results in studies about its incidence. This study was designed to determine the pooled incidence of primary postpartum haemorrhage among women following in-hospital births. Methods This review used a systematic review and meta-analysis approach. We systematically searched electronic databases of Ovid MEDLINE, Ovid Emcare, Embase, PsycINFO, and CINAHL. Studies reporting the incidence of primary postpartum haemorrhage following in-hospital births were included. The pooled incidence of primary postpartum haemorrhage with a 95% confidence interval was calculated using random-effects model. Heterogeneity test between studies, and publication bias were assessed with I-square statistics and Egger’s test respectively. Results Ten of the 1548 studies were found to be eligible and were included in this systematic review and meta-analysis. The pooled incidence of primary postpartum haemorrhage following in-hospital births was nearly 12% (95% CI: 7.74- 17.61), with no evidence of between studies heterogeneity. Conclusions The incidence of primary postpartum haemorrhage following in-hospital births was high, and suggest that preventive strategies implemented to reduce its occurrence needs further strengthening using training. Key messages The result of this review suggests that globally at least one in ten women experience a primary postpartum haemorrhage following in-hospital births. This is higher than anticipated. The application of the recommended strategies for the prevention of primary postpartum haemorrhage should be re-emphasized.

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Effects of the FIFA 11 training program on injury prevention and performance in football players: a systematic review and meta-analysis

Clinical Rehabilitation ◽

10.1177/0269215516675906 ◽

2016 ◽

Vol 31 (5) ◽

pp. 651-659 ◽

Cited By ~ 15

Author(s):

Mansueto Gomes Neto ◽

Cristiano Sena Conceição ◽

Alécio Jorge Alves de Lima Brasileiro ◽

Camila Santana de Sousa ◽

Vitor Oliveira Carvalho ◽

...

Keyword(s):

Confidence Interval ◽

Injury Prevention ◽

Dynamic Balance ◽

Meta Analysis ◽

Mean Difference ◽

Football Players ◽

Weighted Mean ◽

Standard Mean Difference ◽

And Performance ◽

Mean Differences

Objective: To investigate the effects of FIFA 11 training on injury prevention and performance in football players. Design and methods: Systematic review and meta-analysis. We conducted a systematic search using four databases (CINAHL, Cochrane Library, EMBASE, and PubMed) to find controlled trials evaluating the effects of FIFA 11 on injury prevention and performance among football players. Weighted mean differences, standard mean differences, risk ratios, and 95% confidence intervals were calculated, and heterogeneity was assessed using the I2 test. Results: We analyzed 11 trials, including 4700 participants. FIFA 11 resulted in a significant reduction in injury risk (risk ratio = 0.69; 95% confidence interval, 0.49–0.98; P = 0.02) and improvements in dynamic balance (weighted mean difference = 2.68; 95% confidence interval, 0.44–4.92; P = 0.02) and agility (standard mean difference = −0.36; 95% confidence interval, 0.70–0.02; P = 0.04). The meta-analysis indicated a non-significant improvement in jump height (standard mean difference = 0.25; 95% confidence interval, 0.08–0.59; P = 0.14) and running sprint (standard mean difference = −0.24; 95% confidence interval, 0.58–0.10; P = 0.17) in the FIFA 11 group. Conclusions: FIFA 11 can be considered as a tool to reduce the risk of injury. It may improve dynamic balance and agility and can be considered for inclusion in the training of football players.

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Staphylococcus aureus Colonization before Infection Is Not Associated with Mortality among S. aureus-infected Patients: A Meta-analysis

Infection Control and Hospital Epidemiology ◽

10.1086/666628 ◽

2012 ◽

Vol 33 (8) ◽

pp. 796-802 ◽

Cited By ~ 5

Author(s):

Marin L. Schweizer ◽

Ann Bossen ◽

Jennifer S. McDanel ◽

Leslie K. Dennis

Keyword(s):

Staphylococcus Aureus ◽

Confidence Interval ◽

Random Effects ◽

Meta Analysis ◽

Attributable Mortality ◽

Prior History ◽

Random Effects Model ◽

Risk Of Mortality ◽

Increased Risk ◽

History Of

Background and Objective.The literature is conflicted as to whether people colonized with Staphylococcus aureus are at an increased risk of mortality. The aim of this meta-analysis was to review and analyze the current literature to determine whether prior history of S. aureus colonization is associated with mortality among S. aureus-infected patients.Methods.The PUBMED databases were searched with keywords related to S. aureus colonization and mortality. After reviewing 380 article abstracts and 59 articles in detail, only 7 studies had data on the association between S. aureus colonization and mortality among S. aureus-infected patients. Crude estimates of study odds ratios (ORs) were calculated on the basis of data from subset analyses. We pooled crude ORs from the 7 studies using a random-effects model. Woolf's test for heterogeneity was assessed.Results.When all studies were pooled in a random-effects model, no association between S. aureus colonization and mortality among S. aureus-infected patients was seen (pooled OR, 1.08 [95% confidence interval (CI), 0.32–3.66]; n = 7; heterogeneity P = .05). When the analyses were restricted to infection-attributable mortality, the association between colonization and mortality among S. aureus-infected patients was not statistically significant (pooled OR, 0.42 [95% CI, 0.15–1.21]; n = 4; heterogeneity P = .28).Conclusions.S. aureus colonization was not associated with mortality among patients who developed an S. aureus infection. Interventions to decolonize S. aureus carriers may prevent S. aureus infections but may not be sufficient to prevent mortality.

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Preliminary review on the prevalence, proportion, geographical distribution, and characteristics of naturally acquired Plasmodium cynomolgi infection in mosquitoes, macaques, and humans: a systematic review and meta-analysis

BMC Infectious Diseases ◽

10.1186/s12879-021-05941-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Manas Kotepui ◽

Frederick Ramirez Masangkay ◽

Kwuntida Uthaisar Kotepui ◽

Giovanni De Jesus Milanez

Keyword(s):

Systematic Review ◽

Random Effects ◽

Meta Analysis ◽

Human Infection ◽

Preliminary Review ◽

Random Effects Model ◽

Plasmodium Cynomolgi ◽

Pooled Prevalence ◽

Natural Hosts ◽

Mean Differences

Abstract Background Plasmodium cynomolgi is a simian malaria parasite that has been reported as a naturally acquired human infection. The present study aims to systematically review reports on naturally acquired P. cynomolgi in humans, mosquitoes, and macaques to provide relevant data for pre-emptive surveillance and preparation in the event of an outbreak of zoonotic malaria in Southeast Asia. Methods The protocol of the systematic review was registered at PROSPERO with approval ID CRD42020203046. Three databases (Web of Science, Scopus, and MEDLINE) were searched for studies reporting the prevalence of P. cynomolgi infections in Southeast Asian countries between 1946 and 2020. The pooled prevalence or pooled proportion of P. cynomolgi parasitemia in humans, mosquitoes, and macaques was estimated using a random-effects model. Differences in the clinical characteristics of P. cynomolgi infections were also estimated using a random-effects model and presented as pooled odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs). Results Thirteen studies reporting on the prevalence of naturally acquired P. cynomolgi in humans (3 studies, 21 cases), mosquitoes (3 studies, 28 cases), and macaques (7 studies, 334 cases) were included. The results demonstrated that the pooled proportion of naturally acquired P. cynomolgi in humans was 1% (95% CI, 0.1%, I2, 0%), while the pooled proportion of P. cynomolgi infecting mosquitoes was 18% (95% CI, 10–26%, I2, 32.7%). The pooled prevalence of naturally acquired P. cynomolgi in macaques was 47% (95% CI, 27–67%, I2, 98.3%). Most of the cases of naturally acquired P. cynomolgi in humans were reported in Cambodia (62%) and Malaysia (38%), while cases of P. cynomolgi in macaques were reported in Malaysia (35.4%), Singapore (23.2%), Indonesia (17.3%), Philippines (8.5%), Laos (7.93%), and Cambodia (7.65%). Cases of P. cynomolgi in mosquitoes were reported in Vietnam (76.9%) and Malaysia (23.1%). Conclusions This study demonstrated the occurrence of naturally acquired P. cynomolgi infection in humans, mosquitoes, and macaques. Further studies of P. cynomolgi in asymptomatic human cases in areas where vectors and natural hosts are endemic are extensively needed if human infections with P. cynomolgi do become public health problems.

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Alveolar Bone Ridge Augmentation Using Polymeric Membranes: A Systematic Review and Meta-Analysis

Polymers ◽

10.3390/polym13071172 ◽

2021 ◽

Vol 13 (7) ◽

pp. 1172

Author(s):

Manuel Toledano-Osorio ◽

Manuel Toledano ◽

Francisco Javier Manzano-Moreno ◽

Cristina Vallecillo ◽

Marta Vallecillo-Rivas ◽

...

Keyword(s):

Systematic Review ◽

Confidence Interval ◽

Random Effects ◽

Alveolar Bone ◽

Meta Analysis ◽

Scientific Evidence ◽

Polymeric Membranes ◽

Random Effects Model ◽

Screening Process ◽

Ridge Augmentation

Alveolar bone ridge resorption occurred after natural teeth loss and it can restrict the possibility of dental implants placement. The use of bone regenerative procedures is frequently required. The existing evidence regarding the efficacy of horizontal bone ridge augmentation trough guided bone regeneration (GBR) using polymeric membranes was stated. A systematic review and meta-analysis were performed. Electronic and manual literature searches were conducted. Screening process was done using the National Library of Medicine (MEDLINE by PubMed), Embase, and the Cochrane Oral Health. Included articles were randomized controlled trials and observational studies. Weighted means were calculated. Heterogeneity was determined using Higgins (I2). If I2 > 50% a random-effects model was applied. It was found that the mean of horizontal bone gain was 3.95 mm, ranging from 3.19 to 4.70 mm (confidence interval 95%). Heterogeneity is I2 = 99% (confidence interval 95%) and significance of the random-effects model was p < 0.001. The complications rate was 8.4% and membrane exposure was the most frequent. Through this study, we were able to conclude that the existing scientific evidence suggests that GBR using polymeric membranes is a predictable technique for achieving horizontal bone augmentation, thus, permitting a proper further implant placement.

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IL-17A in COVID-19: a meta-analysis

10.21203/rs.3.rs-85350/v2 ◽

2021 ◽

Author(s):

Sukayna Fadlallah ◽

Marcel Shams Eddin ◽

Elias Rahal

Keyword(s):

Meta Analysis ◽

Severe Disease ◽

Serum Levels ◽

Random Effects Model ◽

Weighted Mean ◽

Moderate Disease ◽

Heterogeneity Analysis ◽

Management Approaches ◽

Mean Differences ◽

Significant Publication Bias

Abstract Numerous reviews, commentaries and opinion pieces have suggested targeting IL-17A as part of managing Coronavirus disease 2019 (COVID-19), the notorious pandemic caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IL-17A is a proinflammatory cytokine attributed with homeostatic roles but that is also involved in autoimmune disease pathogenesis. While some studies have reported an increase in IL-17A in subjects affected by COVID-19, no significant associations were found by others. Hence, we undertook this meta-analysis to examine whether serum IL-17A increases in COVID-19 patients. Multiple databases were systematically reviewed for literature published on the topic from January 1, 2020 to April 30, 2021. A random effects model was used to calculate weighted mean differences (WMDs) and 95% confidence interval (CIs) as well as the 𝜏2 and 𝐼2 statistics for heterogeneity analysis. We report that IL-17A increases in COVID-19 subjects irrespective of disease severity compared to controls [WMD=2.51 pg/ml (95% CI 1.73-3.28), p<0.00001]. It is also higher in patients with moderate disease compared to controls [WMD=2.41 pg/ml (95% CI:1.40-3.43), p<0.00001] as well as higher in patients with severe COVID-19 [WMD=4.13 pg/ml (95% CI:1.65-6.60), p=0.001]. While the increase in serum levels in subjects with severe disease over those with moderate disease was statistically significant, the association was not as robust as the other comparisons [WMD= 2.07 pg/ml (95% CI:0.20-3.95), p=0.03]. Variable heterogeneity was observed in the various analyses with no significant publication bias detected. Hence, IL-17A may be of relevance when considering management approaches to COVID-19.

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IL-17A in COVID-19: a meta-analysis

10.21203/rs.3.rs-85350/v1 ◽

2020 ◽

Author(s):

Sukayna Fadlallah ◽

Marcel Shams Eddin ◽

Elias Rahal

Keyword(s):

Autoimmune Disease ◽

Proinflammatory Cytokine ◽

Meta Analysis ◽

Severe Disease ◽

Serum Levels ◽

The Other ◽

Therapeutic Approaches ◽

Disease Pathogenesis ◽

Moderate Disease ◽

Management Approaches

Abstract IL-17A is a proinflammatory cytokine attributed with homeostatic roles but that is also involved in autoimmune disease pathogenesis. While some studies have reported an increase in IL-17A in subjects affected by COVID-19, no significant associations were found by others. Hence, we undertook this meta-analysis to examine whether serum IL-17A increases in COVID-19 patients. We report here that IL-17A increases in COVID-19 subjects irrespective of disease severity. It is also higher in patients with moderate disease compared to controls as well as higher in patients with severe COVID-19. While the increase in serum levels in subjects with severe disease over those with moderate disease was statistically significant, the association was not as robust as the other comparisons. Hence, IL-17A may be of relevance when considering management approaches to COVID-19; however, therapeutic approaches that target IL-17A should consider whether alleviation of inflammation outweighs eliminating the possible anti-viral roles of this cytokine.

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Effects of electromyographic biofeedback interventions for shoulder pain and function: Systematic review and meta-analysis

Clinical Rehabilitation ◽

10.1177/0269215521990950 ◽

2021 ◽

pp. 026921552199095

Author(s):

Danilo Harudy Kamonseki ◽

Letícia Bojikian Calixtre ◽

Rodrigo Py Gonçalves Barreto ◽

Paula Rezende Camargo

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Confidence Interval ◽

Shoulder Pain ◽

Meta Analysis ◽

Quality Of Evidence ◽

Electromyographic Biofeedback ◽

Mean Differences ◽

And Function

Objective: To systematically review the effectiveness of electromyographic biofeedback interventions to improve pain and function of patients with shoulder pain. Design: Systematic review of controlled clinical trials. Literature search: Databases (Medline, EMBASE, CINAHL, PEDro, CENTRAL, Web of Science, and SCOPUS) were searched in December 2020. Study selection criteria: Randomized clinical trials that investigated the effects of electromyographic biofeedback for individuals with shoulder pain. Patient-reported pain and functional outcomes were collected and synthesized. Data synthesis: The level of evidence was synthesized using GRADE and Standardized Mean Differences and 95% confidence interval were calculated using a random-effects inverse variance model for meta-analysis. Results: Five studies were included with a total sample of 272 individuals with shoulder pain. Very-low quality of evidence indicated that electromyographic biofeedback was not superior to control for reducing shoulder pain (standardized mean differences = −0.21, 95% confidence interval: −0.67 to 0.24, P = 0.36). Very-low quality of evidence indicated that electromyographic biofeedback interventions were not superior to control for improving shoulder function (standardized mean differences = −0.11, 95% confidence interval: −0.41 to 0.19, P = 0.48). Conclusion: Electromyographic biofeedback may be not effective for improving shoulder pain and function. However, the limited number of included studies and very low quality of evidence does not support a definitive recommendation about the effectiveness of electromyographic biofeedback to treat individuals with shoulder pain.

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