Ovarian Strumal Carcinoid Tumour: Case Report

BACKGROUND: Ovarian strumal carcinoid is a germ cell tumour characterised by a mixture of thyroid tissue and carcinoid. Ovarian struma is a very rare occurrence with 0.3-1% incidence of all ovarian tumours and 3% of mature teratomas. Primary carcinoid ovarian tumours are still uncommon as a part of mature teratoma or mucinous cystadenoma. There are four major variants of a carcinoid tumour: insular, trabecular, strumal and mucinous. A strumal carcinoid is an unusual form of ovarian teratoma composed of an intimate admixture of thyroid/carcinoid tissues.CASE REPORT: This is a case report of a 59-year old woman with a 5-year clinical history of perimenopausal uterine bleeding and three explorative curettages. Gynaecological and ultrasound examinations revealed ovarian enlargement with a diameter of 50 mm with hypoechoic zones suspected of benign teratoma. The diagnostic test such as Ca-125, AFP, free-T4 and TSH was in normal range. A smooth, solid right ovarian 50 an mm-size tumour, as well as small amount of fluid in the Douglas pouch, was found during the total abdominal hysterectomy, bilateral salpingo-oophorectomy and staging biopsy. The histopathology revealed teratoma with strumal carcinoid tumour IA stage according to AJCC 2010 of the right ovary and negative cytopathology of the fluid from the Douglas pouch. On the postoperative 2-year control, the patient was tumour free, and Ca-125, free-T4 and TSH were in normal range.CONCLUSION: We would like to point out those specific diagnostic tools, such as ultrasound and Ca-125 have low specificity and sensitivity in detection of this rare ovarian malignancy.

Download Full-text

Ovarian Teratoma as an Uncommon Cause of Encephalitis: Anti-Nmdar Syndrome, A Case Report

10.31487/j.crogr.2019.01.01 ◽

2020 ◽

pp. 1-4

Author(s):

Lourdes Sala Climent ◽

Ana R. Calvo Redol ◽

F. Xavier González Tallada ◽

Javier Medrano Juárez ◽

Lourdes Sala Climent ◽

...

Keyword(s):

Case Report ◽

Young Women ◽

Psychiatric Symptoms ◽

Mature Teratoma ◽

Epileptiform Activity ◽

Cognitive Status ◽

Whole Body ◽

Ovarian Teratoma ◽

Nmdar Encephalitis ◽

Adnexal Tumor

Objective: Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a paraneoplastic, immunemediated encephalopathy with a known association with ovarian tumors, more frequently with mature teratoma. Case Report: We present the case of a 20-year-old patient presenting with fever for 3 weeks and an acute onset of cognitive disturbances. The initial suspicion was that of an infective encephalopathy; however, the lumbar puncture results were negative. Electroencephalography reported epileptiform activity in anterior horns, supporting a diagnosis of encephalopathy. Extensive autoimmune screening was done and found to be positive for anti-NMDAR antibodies. A whole body-TC found a right adnexal tumor compatible with ovarian teratoma. At laparoscopy, the right adnexal tumor was excised, preserving most of the ovarian parenchyma; and histology confirmed a mature teratoma with neural tissue. There were no postoperative complications. The patient recovered normal speech and her former cognitive status, within 40 days from the day after surgery. Conclusion: The association ovarian teratoma-anti-NMDAR encephalitis is a serious and potentially fatal pathology occurring in young women and under-recognized in many countries and among gynaecologists. Given the recent discovery, special attention should be given to possible behavioural changes and psychiatric symptoms that may occur in young women with apparently unknown cause. It is also very important the diagnostic confirmation through the positivity of the anti-NMDAR antibodies, the diagnosis of the underlying tumour and the early tumour excision; since, the earlier the treatment is, the greater is the rate of success and the clinical remission.

Download Full-text

Exogastric Mature Teratoma in an Infant: A Case Report

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2006.55.2.149 ◽

2006 ◽

Vol 55 (2) ◽

pp. 149

Author(s):

Jung Wook Seo ◽

Yoon Joon Hwang ◽

Su Young Kim ◽

Gham Hur ◽

Soon Joo Cha

Keyword(s):

Case Report ◽

Mature Teratoma

Download Full-text

Primary Peritoneal Serous Psammocarcinoma: a Case Report

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.242.pert ◽

2015 ◽

Vol 24 (2) ◽

pp. 253-256 ◽

Cited By ~ 1

Author(s):

Răzvan Dan Togănel ◽

Ioan Şimon ◽

Adriana Zolog ◽

Răzvan Simescu ◽

Angela Cozma ◽

...

Keyword(s):

Adjuvant Chemotherapy ◽

Posterior Wall ◽

Ca 125 ◽

Low Grade ◽

Abdominal Girth ◽

Treatment Protocols ◽

Standardized Treatment ◽

Pelvic Peritonectomy ◽

Optimal Debulking ◽

Douglas Pouch

Background: Psammocarcinomas (PCas) are rare epithelial tumors, usually originating in the ovaries or the peritoneum. These tumors are morphologically characterized by extensive psammomatous calcifications, invasiveness and low-grade cytological features.Case report: We present the case of a 54-year-old woman who was referred to our department with an umbilical tumor and increasing abdominal girth. The patient had had an umbilical hernia for more than 20 years. The CA 125 level was normal. The CT scan showed small peritoneal nodules at the level of the Douglas pouch, including the posterior wall of the uterus, and the entire colon, as well as large nodules located on the caecum and the sigmoid colon. We performed partial enterectomy, total colectomy with ileo-rectal anastomosis, omentectomy, total histerectomy and bilateral adnexectomy, pelvic peritonectomy of the Douglas pouch. Pathology findings were consistent with F.I.G.O. stage IIIC peritoneal PCa. The patient received adjuvant chemotherapy with Taxol and Carboplatin. To date, twelve months after surgery, the follow-up shows no evidence of disease.Conclusion: Standardized treatment protocols are hindered by the rarity of the PCas. However, literature concludes that optimal debulking is mandatory, whereas the efficacy of adjuvant chemotherapy remains to be elucidated.

Download Full-text

Cystic struma ovarii, a rare form of ovarian tumor – a case report, and review of the literature

Orvosi Hetilap ◽

10.1556/oh.2007.28202 ◽

2007 ◽

Vol 148 (48) ◽

pp. 2285-2287 ◽

Cited By ~ 1

Author(s):

Gabriella Östör ◽

Ildikó Tóth ◽

Zsuzsanna Hrubyné Tóth ◽

Sándor Bazsa

Keyword(s):

Case Report ◽

Ovarian Tumor ◽

Ca 125 ◽

Struma Ovarii ◽

Review Of The Literature ◽

Rare Form

Az ovarialis strumák a petefészek-teratomák kevesebb mint 3%-át adják. Megjelenhet bennük a pajzsmirigy szinte minden betegsége, és előfordulhat malignitás is. A szerzők esetében egy 31 éves nő bal oldali petefészekcisztáját távolították el, amely az ovariumcarcinoma klinikai tüneteit mutatta, úgymint nagy hasi térfoglalás, ascites, emelkedett szérum-CA 125-szint. A szövettani diagnózis benignus struma ovarii volt. A posztoperatív pajzsmirigyműködés normális maradt.

Download Full-text

Mature teratoma splitting the brainstem in a newborn: case report

Journal of Neurosurgery Pediatrics ◽

10.3171/2019.5.peds19142 ◽

2019 ◽

Vol 24 (4) ◽

pp. 371-375

Author(s):

Li-tal Pratt ◽

Shelly I. Shiran ◽

Ronit Precel ◽

Liat Ben-Sira ◽

Gustavo Malinger ◽

...

Keyword(s):

Case Report ◽

Prenatal Diagnosis ◽

Posterior Fossa ◽

Mature Teratoma

Mature teratomas (MTs) of the posterior fossa are extremely rare. The authors present a case of a prenatal diagnosis of an MT splitting the brainstem. Representative images as well as the clinical and surgical course are presented. Literature regarding “split brainstem” and MT of the posterior fossa is discussed.

Download Full-text

Synchronous primary malignancy of ovary and cervix with different histopathology: A rare case report

10.1055/s-0039-1685388 ◽

2016 ◽

Author(s):

Alok Tiwari ◽

Dhananjay Gughe ◽

Radhika Dureja ◽

Satinder Kaur

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Contrast Enhancement ◽

Squamous Cell ◽

Pap Smear ◽

Ca 125 ◽

Post Contrast ◽

Palpable Mass ◽

Diffusion Restriction

Concurrent different histopathological types of gynecologic tumors arise rarely. We present ovarian serous and cervical squamous cell carcinoma formed synchronously. A 51-year-old woman with a poor general condition was admitted with gradual distension of abdomen for 1 year with gradual loss of weight and appetite for the last three months and pain in the abdomen and irregular vaginal bleeding for the last two months. There was no family history of malignancy of genital tract, breast or colon. On examination she was cachexic, pale, dehydrated, tachypnoeic and had edema over feet. Per abdomen examination revealed solid, non-mobile palpable mass arising from pelvis. Per vaginal examination revealed large mass in pelvis and uterus can not be felt separately on per speculum examination there was small endocervical erosion, hypertrophied cervix. On per rectal examination bilateral parametria were free. Her tumor marker were evaluated and CA-125 was found to be raised (CA 125: 915.6 u/ml U/mL); rest tumor markers were normal. Cervical punch biopsy was suggestive of moderately differentiated carcinoma and pap smear was also suggestive of cervical cancer. MRI findings revealed a mass of altered signal intensity 2.5 × 1.5 × 2.2 cm with diffusion restriction and post contrast enhancement in the anterior lip of cervix and another large, lobulated predominantly solid mass, hypo intense on T1, intermediate on T2 with diffusion restriction and post contrast enhancement in the right adnexal region abutting the small bowel and sigmoid colon optimal debulking surgery with standard protocol was done. Histopathology report revealed squamous cell carcinoma of cervix, grade III and high grade serous cystadenocarcinoma of ovary. Tumour deposits from ovary were seen on right fallopian tube and right parametrium. Squamous cell carcinoma cervix involved ectocervix, endocervix and infiltrated near full thickness of cervical stroma, endomyometrium, vaginal cuff, paracervical tissue omentum and appendix were free of tumour. Twenty five right pelvic lymphnodes dissected were free of tumour, (00/25). One out of fifteen lymphnode dissected were involved with extra capsular extent, 01/15 and thirteen para aortic lymph node dissected were free of tumor. Immunohistochemistry markers: Ovarian mass-tumour cell expressed ck, vimentin, wt-1 with focal Ck positivity, no expression of ck20, p63, ck5/6 and CEA seen. Cervical tumour-tumour cells expressed ck, ck7, p63 and ck5/6 no expression of ck20, wt-1. Based on our case report we need to keep in mind that even if patient presents with symptoms pertaining to a single malignancy; still the rare possibility of synchronous malignancies should be looked for by doing proper investigations. In our case, patient had symptoms pertaining to ovarian malignancy; whereas cervical malignancy was diagnosed after investigating the patient. Histologic examination should be done properly as the prognosis depends on the malignancies being metastatic or synchronous one appropriate management should be offered in all such cases. Long term follow up of such patients should be maintained to determine the prognosis.

Download Full-text

696: Glycoprofiling of serous ovarian tumours is a promising strategy for developing new diagnostic tools

European Journal of Cancer ◽

10.1016/s0959-8049(14)50614-4 ◽

2014 ◽

Vol 50 ◽

pp. S167

Author(s):

S. Ricardo ◽

L. Silva ◽

D. Pereira ◽

N. Lunet ◽

L. David

Keyword(s):

Diagnostic Tools ◽

Promising Strategy ◽

Ovarian Tumours

Download Full-text

Meigs' syndrome with elevated CA 125: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802003000500007 ◽

2003 ◽

Vol 121 (5) ◽

pp. 210-212 ◽

Cited By ~ 10

Author(s):

Sabas Carlos Vieira ◽

Leonardo Halley Carvalho Pimentel ◽

José Carlos Castelo Branco Ribeiro ◽

Argemiro Ferreira de Andrade Neto ◽

Jerúsia Oliveira Ibiapina de Santana

Keyword(s):

Case Report ◽

Pleural Effusion ◽

Ovarian Tumor ◽

Frozen Section ◽

Transvaginal Ultrasound ◽

Elevated Serum ◽

Ca 125 ◽

Brazilian Woman ◽

Thoracic Drainage ◽

Benign Ovarian Tumor

CONTEXT: Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor. However, patients with Meigs' syndrome can also have elevated serum CA 125 levels. The authors report a case of Meigs' syndrome with elevated CA 125 level. OBJECTIVE: This is a case report of Meigs' syndrome with elevated CA 125 level. CASE REPORT: A 65-year-old Brazilian woman had presented progressive dyspnea, weight loss and decline in general condition over the 7 months preceding admission to our service. In another hospital, the patient had been submitted to thoracic drainage due to pleural effusion. With recurrence of the pleural effusion and increase in abdominal volume due to ascites and a pelvic mass, the patient sought our service. Transvaginal ultrasound showed an extensive adnexal solid mass of 16.4 x 10.8 cm located in the pelvis without exact limits, and the serum CA 125 level was elevated. With a preoperative diagnosis of ovarian carcinoma, the patient was submitted to exploratory laparotomy, which revealed a left ovarian tumor. The frozen section diagnosis was thecoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The histology of the specimen confirmed the diagnosis of thecoma. The patient was asymptomatic with a normal serum CA 125 level 20 months after the operation.

Download Full-text