696: Glycoprofiling of serous ovarian tumours is a promising strategy for developing new diagnostic tools

2014 ◽  
Vol 50 ◽  
pp. S167
Author(s):  
S. Ricardo ◽  
L. Silva ◽  
D. Pereira ◽  
N. Lunet ◽  
L. David
Keyword(s):  
Diagnostic Tools ◽  
Promising Strategy ◽  
Ovarian Tumours

scholarly journals Ovarian Strumal Carcinoid Tumour: Case Report

2018 ◽  
Vol 6 (3) ◽  
pp. 540-543 ◽  
Author(s):  
Vesna S. Antovska ◽  
Iskra Krstevska ◽  
Milka Trajanova ◽  
Irena Gosheva ◽  
Jasmina Chelebieva ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoid Tumour ◽  
Mature Teratoma ◽  
Ca 125 ◽  
Ovarian Teratoma ◽  
Diagnostic Tools ◽  
Free T4 ◽  
Ovarian Tumours ◽  
Strumal Carcinoid ◽  
Douglas Pouch

BACKGROUND: Ovarian strumal carcinoid is a germ cell tumour characterised by a mixture of thyroid tissue and carcinoid. Ovarian struma is a very rare occurrence with 0.3-1% incidence of all ovarian tumours and 3% of mature teratomas. Primary carcinoid ovarian tumours are still uncommon as a part of mature teratoma or mucinous cystadenoma. There are four major variants of a carcinoid tumour: insular, trabecular, strumal and mucinous. A strumal carcinoid is an unusual form of ovarian teratoma composed of an intimate admixture of thyroid/carcinoid tissues.CASE REPORT: This is a case report of a 59-year old woman with a 5-year clinical history of perimenopausal uterine bleeding and three explorative curettages. Gynaecological and ultrasound examinations revealed ovarian enlargement with a diameter of 50 mm with hypoechoic zones suspected of benign teratoma. The diagnostic test such as Ca-125, AFP, free-T4 and TSH was in normal range. A smooth, solid right ovarian 50 an mm-size tumour, as well as small amount of fluid in the Douglas pouch, was found during the total abdominal hysterectomy, bilateral salpingo-oophorectomy and staging biopsy.  The histopathology revealed teratoma with strumal carcinoid tumour IA stage according to AJCC 2010 of the right ovary and negative cytopathology of the fluid from the Douglas pouch. On the postoperative 2-year control, the patient was tumour free, and Ca-125, free-T4 and TSH were in normal range.CONCLUSION: We would like to point out those specific diagnostic tools, such as ultrasound and Ca-125 have low specificity and sensitivity in detection of this rare ovarian malignancy.

scholarly journals Comparison of estradiol and progesteron serum levels in ferrets suffering from hyperoestrogenism and ovarian neoplasia

2009 ◽  
Vol 54 (No. 11) ◽  
pp. 532-536 ◽  
Author(s):  
K. Hauptman ◽  
V. Jekl ◽  
G.M. Dorrestein ◽  
M. Vyskocil ◽  
Z. Knotek
Keyword(s):  
Serum Levels ◽  
Diagnostic Tools ◽  
Serum Concentrations ◽  
Negative Effects ◽  
Serum Progesterone ◽  
Clinical Procedures ◽  
Ovarian Tumours ◽  
Ovarian Neoplasia ◽  
Healthy Females

The aim of this study was to determine whether serum levels of 17beta-estradiol and progesterone are significant diagnostic tools for the confirmation of specific reproductive diseases associated with hyperestrogenism. Thirty-one adult ferrets (<i>Mustela putorrius furo</i>) were divided into five groups. The levels of serum 17beta-estradiol differed significantly when comparing females with ovarian tumors (817.80 ± 433.90 pmol/l) to intact (83.50 ± 32.53 pmol/l) and spayed, healthy females (73.17 ± 0.41 pmol/l) as well as to females with prolonged estrus (274.75 ± 192.40 pmol/l). Concentrations of serum progesterone differed significantly when comparing females with ovarian tumours (2.10 ± 1.85 ng/ml) to intact (0.40 ± 0.40 ng/ml) and spayed, healthy females (0.30 ± 0.12 ng/ml). Our study has made it clear that a determination of serum concentrations of 17-beta estradiol and progesterone is not sufficient for distinguishing between prolonged estrus and the presence of ovarian tumours. Therefore, it is advisable to employ other clinical procedures, such as ones allowing organ visualization. Increased concentrations of 17beta-estradiol in ferrets persisted for two weeks after hCG administration. This is particularly important in clinical practice, as negative effects of estrogens on bone marrow could persist for more than 14 days. Therefore, ferrets should be clinically monitored for a longer period of time.

scholarly journals Ovarian mass in pregnancy: case series

2020 ◽  
Vol 9 (10) ◽  
pp. 4290
Author(s):  
M. R. Manvi ◽  
Radhika Deshpande
Keyword(s):  
Multidisciplinary Approach ◽  
Case Series ◽  
Diagnostic Tools ◽  
Ovarian Mass ◽  
Medical Sciences ◽  
Surgical Interventions ◽  
Ovarian Tumours ◽  
Magnetic Resonance Imaging Mri ◽  
Ovarian Masses ◽  
In Pregnancy

Ovarian masses in pregnancy are not uncommon. Ovarian masses during pregnancy should be accurately evaluated to identify the patients who need surgical interventions from those where it can be managed conservatively. Ultrasound and magnetic resonance imaging (MRI) are safe diagnostic tools during pregnancy. The overall incidence of ovarian tumours in pregnancy is 2.4-5.7%. Most masses are functional and asymptomatic and up to 70% resolve spontaneously in the second trimester. Both open surgery and laparoscopy can be performed considering the tumour diameter, gestational age and associated complications. A multidisciplinary approach is necessary in case of high suspicion of malignancy. This study evaluates the clinical features, course in pregnancy, management and pregnancy outcome in patients with ovarian masses diagnosed during pregnancy. This was a retrospective analysis of medical records of 6 patients diagnosed with ovarian mass during pregnancy in the department of Obstetrics and Gynaecology at Kanachur Institute of Medical Sciences, Mangalore from June 2019 to June 2020.

Developing an Effective Framework for the Augmentative and Alternative Communication Evaluation Process

2014 ◽  
Vol 23 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Celeste R. Helling ◽  
Jamila Minga
Keyword(s):  
Augmentative And Alternative Communication ◽  
Evaluation Process ◽  
Assessment Process ◽  
Diagnostic Tools ◽  
Alternative Communication ◽  
Complex Communication Needs ◽  
Expressive Communication ◽  
Communication Evaluation ◽  
Communication Needs

A comprehensive augmentative and alternative communication (AAC) evaluation is critical to providing a viable means of expressive communication for nonverbal people with complex communication needs. Although a number of diagnostic tools are available to assist AAC practitioners with the assessment process, there is a need to tailor the evaluation process to the specific communication needs of the AAC user. The purpose of this paper is to provide a basis for developing an effective and clinically driven framework for approaching a user-tailored AAC evaluation process.

Gastroesophageal Reflux Disease: A Gastroenterologist's Perspective

2011 ◽  
Vol 21 (3) ◽  
pp. 89-99
Author(s):  
Michael F. Vaezi
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Best Practice ◽  
Clinical Care ◽  
Diagnostic Testing ◽  
Diagnostic Tools ◽  
Swallowing Function ◽  
Atypical Symptoms

Gastroesophageal reflux disease (GERD) is a commonly diagnosed condition often associated with the typical symptoms of heartburn and regurgitation, although it may present with atypical symptoms such as chest pain, hoarseness, chronic cough, and asthma. In most cases, the patient's reduced quality of life drives clinical care and diagnostic testing. Because of its widespread impact on voice and swallowing function as well as its social implications, it is important that speech-language pathologists (SLPs) understand the nature of GERD and its consequences. The purpose of this article is to summarize the nature of GERD and GERD-related complications such as GERD-related peptic stricture, Barrett's esophagus and adenocarcinoma, and laryngeal manifestations of GERD from a gastroenterologist's perspective. It is critical that SLPs who work with a multidisciplinary team understand terminology, diagnostic tools, and treatment to ensure best practice.

Mentoring: A Promising Strategy for Youth Development

2001 ◽  
Author(s):  
Susan M. Jekielek ◽  
Kristin M. Moore ◽  
Elizabeth C. Hair ◽  
Harriet J. Scarupa
Keyword(s):  
Youth Development ◽  
Promising Strategy

Molecular genetic markers for thyroid FNAB

2015 ◽  
Vol 54 (03) ◽  
pp. 94-100 ◽  
Author(s):  
P. B. Musholt ◽  
T. J. Musholt
Keyword(s):  
Genetic Markers ◽  
Thyroid Nodules ◽  
Molecular Genetic ◽  
Genetic Alterations ◽  
Diagnostic Tools ◽  
Ultrasound Screening ◽  
Thyroid Malignancy ◽  
Thyroid Carcinomas ◽  
Molecular Genetic Markers ◽  
The Impact

SummaryAim: Thyroid nodules > 1 cm are observed in about 12% of unselected adult employees aged 18–65 years screened by ultrasound scan (40). While intensive ultrasound screening leads to early detection of thyroid diseases, the determination of benign or malignant behaviour remains uncertain and may trigger anxieties in many patients and their physicians. A considerable number of thyroid resections are consecutively performed due to suspicion of malignancy in the detected nodes. Fine needle aspiration biopsy (FNAB) has been recommended for the assessment of thyroid nodules to facilitate detection of thyroid carcinomas but also to rule out malignancy and thereby avoid unnecessary thyroid resections. However, cytology results are dependent on experience of the respective cytologist and unfortunately inconclusive in many cases. Methods: Molecular genetic markers are already used nowadays to enhance sensitivity and specificity of FNAB cytology in some centers in Germany. The most clinically relevant molecular genetic markers as pre-operative diagnostic tools and the clinical implications for the intraoperative and postoperative management were reviewed. Results: Molecular genetic markers predominantly focus on the preoperative detection of thyroid malignancies rather than the exclusion of thyroid carcinomas. While some centers routinely assess FNABs, other centers concentrate on FNABs with cytology results of follicular neoplasia or suspicion of thyroid carcinoma. Predominantly mutations of BRAF, RET/PTC, RAS, and PAX8/PPARγ or expression of miRNAs are analyzed. However, only the detection of BRAF mutations predicts the presence of (papillary) thyroid malignancy with almost 98% probability, indicating necessity of oncologic thyroid resections irrespective of the cytology result. Other genetic alterations are associated with thyroid malignancy with varying frequency and achieve less impact on the clinical management. Conclusion: Molecular genetic analysis of FNABs is increasingly performed in Germany. Standardization, quality controls, and validation of various methods need to be implemented in the near future to be able to compare the results. With increasing knowledge about the impact of genetic alterations on the prognosis of thyroid carcinomas, recommendations have to be defined that may lead to individually optimized treatment strategies.

The uncalibrated prothrombinase-induced clotting time test

2010 ◽  
Vol 30 (04) ◽  
pp. 212-216 ◽  
Author(s):  
R. Jovic ◽  
M. Hollenstein ◽  
P. Degiacomi ◽  
M. Gautschi ◽  
A. Ferrández ◽  
...  
Keyword(s):  
Factor Xa ◽  
Heparin Therapy ◽  
Thrombin Inhibitors ◽  
Coagulation Cascade ◽  
Diagnostic Tools ◽  
Direct Thrombin Inhibitors ◽  
Functional Assay ◽  
Clotting Time ◽  
Coagulation Time ◽  
Time Test

SummaryThe activated partial thromboplastin time test (aPTT) represents one of the most commonly used diagnostic tools in order to monitor patients undergoing heparin therapy. Expression of aPTT coagulation time in seconds represents common practice in order to evaluate the integrity of the coagulation cascade. The prolongation of the aPTT thus can indicate whether or not the heparin level is likely to be within therapeutic range. Unfortunately aPTT results are highly variable depending on patient properties, manufacturer, different reagents and instruments among others but most importantly aPTT’s dose response curve to heparin often lacks linearity. Furthermore, aPTT assays are insensitive to drugs such as, for example, low molecular weight heparin (LMWH) and direct factor Xa (FXa) inhibitors among others. On the other hand, the protrombinase-induced clotting time assay (PiCT®) has been show to be a reliable functional assay sensitive to all heparinoids as well as direct thrombin inhibitors (DTIs). So far, the commercially available PiCT assay (Pefakit®-PiCT®, DSM Nutritional Products Ltd. Branch Pentapharm, Basel, Switzerland) is designed to express results in terms of units with the help of specific calibrators, while aPTT results are most commonly expressed as coagulation time in seconds. In this report, we describe the results of a pilot study indicating that the Pefakit PiCT UC assay is superior to the aPTT for the efficient monitoring of patients undergoing UFH therapy; it is also suitable to determine and quantitate the effect of LMWH therapy. This indicates a distinct benefit when using this new approach over the use of aPPT for heparin monitoring.

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