Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin

Objective: Increased red cell distribution width (RDW) has been associated with poor prognosis in patients with heart failure (HF) and coronary heart disease (CHD) in multiple observation studies. We conducted this meta-analysis to determine composite impact of RDW on cardiovascular outcomes in patients with HF and CHD. Methodology: Literature search of databases such as PubMed/Medline, Google Scholar, and Cochrane library was conducted from inception till 16 th August, 2020 to identify all the relevant studies reporting all-cause mortality based on the RDW levels in patients with HF and CHD (ST- elevation & non-ST elevation myocardial infarction, coronary artery disease). The data was extracted from retrieved results for performing this systematic review and meta-analysis. Results: A total of 32 studies were included with a total of 58, 518 patients. The ages ranged from 49-80 years with males being 47%–98% in proportion. We observed that the pooled estimate of hazard ratio (HR) for all-cause mortality among patients with congestive heart failure (CHF) was 1.16 (95% CI 1.10–1.23; p <0.001), and the pooled HR for all-cause mortality among CHD patients was 1.19 (95% CI 1.09–1.29; p = 0.001) in patients with elevated RDW levels. Conclusion: Elevated RDW levels either at the time of admission, during the course of stay in hospital, or at the time of discharge significantly correlate with the increased all-cause mortality among CHF and CHD patients. Elevated RDW can have prognostic importance in anticipating the risk of death in these subset of patients. Keywords: Red cell distribution width; congestive heart failure; coronary artery/heart disease; all-cause mortality.

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Comparison of Red Cell Distribution Width (RDW) Value in Congestive Heart Failure (CHF) Patients with Normal Persons

International Journal of Research and Review ◽

10.52403/ijrr.20210806 ◽

2021 ◽

Vol 8 (8) ◽

pp. 27-30

Author(s):

Marhani Yunita ◽

Herman Hariman

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Cardiac Dysfunction ◽

Red Cell Distribution Width ◽

Hematological Parameter ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Normal People ◽

Significant Difference

Congestive Heart Failure (CHF) is a complex clinical symptom that is often characterized by structural abnormalities or cardiac dysfunction that impairs the ability of the left ventricle (LV) to fill or pump blood, especially during physical activity. Red Cell Distribution Width (RDW) is a simple, fast, inexpensive and direct hematological parameter, which reflects the level of anisocytosis in vivo. The association between impaired hematopoiesis and cardiac dysfunction is based on the fact that many different conditions are associated with increased heterogeneity of erythrocyte volume, which can be concurrently present in patients with heart failure, while anisocytosis can also directly contribute to the development and worsening of heart failure. This study aims to provide a comparison of RDW values between CHF patients and normal people. This study uses a case control study design where as many as 20 people with CHF will be compared their RDW values with 20 normal people. From a total of 40 patients, the average RDW value in CHF patients was 17.7±2.4 higher than the average RDW value for normal people was 12.6±0.4 and from the results of statistical analysis using the Independent Student t test obtained p value <0.001. There is a significant difference between the RDW values of CHF patients compared to normal people. Keywords: Congestive Heart Failure, CHF, Red Cell Distribution Width, RDW.

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