Monocyte distribution width as a novel sepsis indicator in COVID-19 patients

Background The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly transmittable virus which causes the novel coronavirus disease (COVID-19). Monocyte distribution width (MDW) is an in-vitro hematological parameter which describes the changes in monocyte size distribution and can indicate progression from localized infection to systemic infection. In this study we evaluated the correlation between the laboratory parameters and available clinical data in different quartiles of MDW to predict the progression and severity of COVID-19 infection. Methods A retrospective analysis of clinical data collected in the Emergency Department of Rashid Hospital Trauma Center-DHA from adult individuals tested for SARS-CoV-2 between January and June 2020. The patients (n = 2454) were assigned into quartiles based on their MDW value on admission. The four groups were analyzed to determine if MDW was an indicator to identify patients who are at increased risk for progression to sepsis. Results Our data showed a significant positive correlation between MDW and various laboratory parameters associated with SARS-CoV-2 infection. The study also revealed that MDW ≥ 24.685 has a strong correlation with poor prognosis of COVID-19. Conclusions Monitoring of monocytes provides a window into the systemic inflammation caused by infection and can aid in evaluating the progression and severity of COVID-19 infection.

Ethanol Extract of Brassica Rapa Attenuate the Complete Freund’s Adjuvant-Induced Inflammation in Rats

Turnip is an ancient edible plant belongs to family Braaicacaceae. Traditionally it is used for the treatment of various disorders such as diabetes, hepatotoxicity, ulcer, and anti-inflammatory activity. Therefore the current investigation was attempted to investigate the anti-inflammatory activity of Brassica rapa root extract against complete fluids adjuvant induced inflammation in experimental animals. The Ethanol extract of Brassica rapa was prepared by a hot extraction procedure and phytochemical analysis of different extract was done by different chemical tests. Daily oral treatment of indomethacin, and extract for twenty-one days after three days of CFA administration significantly decrease the paw volume, hepatic biomarkers as well as ameliorated the level of a hematological parameter such as hemoglobin, RBC, WBC, ESR and bodyweight of experimental animals. From the result of the current investigation, it can be concluded that the Brassica rapa extract possesses anti-inflammatory activity. Further study is required to explore the mechanism responsible for its anti-inflammatory activity.

Comparison of Hemoglobin (Hb) and Hematocrit (HCT) Value in Normal and Cancer Patients- An In-vitro Study

Introduction: Hemoglobin is the molecule in Red blood cells (RBC) that carries oxygen from the lungs to the body's tissues and returns carbon dioxide gas from the tissues back to the lungs. The hematocrit is the ratio of the quantity of Red blood cells to the amount of these components together, called blood. The hematocrit measures the amount of red blood cells compared to the whole blood volume (red blood cells and plasma). The research is required to find out whether the cancer affects the traditional Hb and HCT value. Aim: The aim of this study is to evaluate the difference between the normal and cancer patient’s Hb and HCT values. Materials and Methods: A Total of 20 samples were included in this study. Divided into two groups of normal and cancer patients. The details of Hemoglobin and Hematocrit values were noted down from the routine Complete blood count analysis and regression analysis is done through SPSS version 23. Results: The results showed that there is significant difference between the Hemoglobin and Hematocrit value between normal and cancerous patients. Comparison of Hemoglobin and Hematocrit value in normal and cancer patients showed mean value of the Hb in control patients as 13.9g/dl with a standard deviation of 1.4 and in squamous cell carcinoma as 12.97g/dl with a standard deviation of 2.6 and the mean value of the HCT in the control group is 40.5% with a standard deviation of 3.9 and in the cancer group it is 39.0 with a standard deviation of 7.7. with a significant difference between Hb and HCT level with a p value <0.05 Conclusion: The study found that there is a significant difference between the Hemoglobin and Hematocrit value among Squamous cell carcinoma compared to normal patients. As the therapy for cancers target the bone marrow, proliferative cells, the hematological parameter analysis is necessary to know the prognosis of the cancer individual.

Prognostic and Clinicopathological Significance of the Systemic Immune-Inflammation Index in Patients With Renal Cell Carcinoma: A Meta-Analysis

BackgroundThe systemic immune-inflammation index (SII) is a hematological parameter based on neutrophil, platelet, and lymphocyte counts. Studies that have investigated the prognostic value of SII in patients with renal cell carcinoma (RCC) have reported controversial results. In this study, we systematically investigated the prognostic value of SII in patients with RCC.MethodsWe systematically searched English articles in the PubMed, Embase, Web of Science, and Cochrane Library databases up to October 2021. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were used to obtain pooled results.ResultsThe meta-analysis included 10 studies that enrolled 3,180 patients. A high SII was associated with poor overall survival (HR 1.75, 95% CI 1.33–2.30, p&lt;0.001) in patients with RCC. However, a high SII was not shown to be a significant prognostic factor for progression-free survival/disease-free survival (HR 1.22, 95% CI 0.84–1.76, p=0.293) or poor cancer-specific survival (HR 1.46, 95% CI 0.68–3.12, p=0.332) in patients with RCC. A high SII was correlated with male sex (OR 1.51, 95% CI 1.11–2.04, p=0.008), Fuhrman grade G3–G4 (OR 1.80, 95% CI 1.08–3.00, p=0.024), and poor risk based on the International Metastatic Renal Cell Carcinoma Database Consortium criteria (OR 19.12, 95% CI 9.13–40.06, p&lt;0.001).ConclusionA high SII was independently associated with poor survival outcomes in patients with RCC. Additionally, an elevated SII indicated more aggressive disease. The SII may serve as a useful cost-effective prognostic indicator in patients with RCC.

Plasmodiasis in Relation to Haematological Parameters among Children in the Internally Displaced Persons Camps (IDPS) within Maiduguri, Nigeria

Introduction: Malaria parasite is a protozoan disease that is transmitted by female anopheles mosquito which infects humans regardless of age, sex and status. It has a worldwide distribution and often prevalent in the developing countries and areas with poor environmental hygiene this study focuses on the incidence of plasmodiasis in relation to haematological parameters among children in the Internally Displaced Persons (IDPs) camp. Methods: blood samples were collected via venipuncture for thick blood film and was stained with giemsa diluted 1:10 and rapid diagnostic techniques (RDT), while the hematological parameter were analyzed by auto analyzer machine. Results: a total of two hundred and one (201) samples were obtained from two different camps in the study area. 87 were obtained from Stadium IDPs camp and 114 from Bakassi camp. From the Stadium IDPs camp 25(12.4%) were malaria positive and 62(30.8%) were negative. Similarly, from Bakassi IDPs camp, 58(28.9%) were positive and 56(27.9%) were negative. Conclusions: Males were shown to have eosinophilia compared to the females, due to an increase in the eosinophil count in them which can be used to predict the intensity of malaria infection, and a decrease in the eosinophil in females. There was a partial negative correlation due to a decrease in the monocyte and lymphocyte with increasing parasite density count.

Monocyte Distribution Width As A Novel Sepsis Indicator in COVID-19 Patients

Background The severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly transmittable virus which causes the novel coronavirus disease (COVID-19). Monocyte distribution width (MDW) is an in-vitro hematological parameter which describes the changes in monocyte size distribution and can indicate progression from localized infection to systemic infection. In this study we evaluated the correlation between the laboratory parameters and available clinical data in different quartiles of MDW to predict the progression and severity of COVID-19 infection. Methods A retrospective analysis of clinical data collected in the Emergency Department of Rashid Hospital Trauma Center-DHA from adult individuals tested for SARS-CoV-2 between January and June 2020. The patients (n = 2454) were assigned into quartiles based on their MDW value on admission. The four groups were analyzed to determine if MDW was an indicator to identify patients who are at increased risk for progression to sepsis. Results Our data showed a significant positive correlation between MDW and various laboratory parameters associated with SARS-CoV-2 infection. The study also revealed that MDW ≥ 24.685 has a strong correlation with poor prognosis of COVID-19. Conclusions Monitoring of monocytes provides a window into the systemic inflammation caused by infection and can aid in evaluating the progression and severity of COVID-19 infection.

Comparison of Red Cell Distribution Width (RDW) Value in Congestive Heart Failure (CHF) Patients with Normal Persons

Congestive Heart Failure (CHF) is a complex clinical symptom that is often characterized by structural abnormalities or cardiac dysfunction that impairs the ability of the left ventricle (LV) to fill or pump blood, especially during physical activity. Red Cell Distribution Width (RDW) is a simple, fast, inexpensive and direct hematological parameter, which reflects the level of anisocytosis in vivo. The association between impaired hematopoiesis and cardiac dysfunction is based on the fact that many different conditions are associated with increased heterogeneity of erythrocyte volume, which can be concurrently present in patients with heart failure, while anisocytosis can also directly contribute to the development and worsening of heart failure. This study aims to provide a comparison of RDW values between CHF patients and normal people. This study uses a case control study design where as many as 20 people with CHF will be compared their RDW values with 20 normal people. From a total of 40 patients, the average RDW value in CHF patients was 17.7±2.4 higher than the average RDW value for normal people was 12.6±0.4 and from the results of statistical analysis using the Independent Student t test obtained p value <0.001. There is a significant difference between the RDW values of CHF patients compared to normal people. Keywords: Congestive Heart Failure, CHF, Red Cell Distribution Width, RDW.

A Comparative Study of Coagulation Profile and Haematological Parameters in Pregnancy Induced Hypertension (PIH).

o evaluate the changes in PIH (Pregnancy Induced Hypertension) by using haematologicaland coagulation parameters like platelet count, MPV, PDW, PT and APTT. Materials and methods: Atotal of 150 cases comprising 75 control groups and 75 cases group (pregnancy-inducedhypertension) were enrolled in the study. Hematological parameters like platelet count, MPV, PDWand coagulation parameters like PT and APTT were studied in these patients. Data entry was done inan excel spreadsheet and by using SPSS (version -20). Results: The hematological parameter -Platelet count was markedly reduced in patients with preeclampsia compared to normal pregnantpatients. MPV, PDW, PT and APTT were increased which is statistically significant. Conclusion: Theabnormalities about hematological and coagulation parameters in preeclampsia are the prognosticmarkers used as an additional diagnostic criterion for preeclampsia in rural hospitals.

Cardiovascular Implantable Electronic Device Infection and New Insights About Correlation Between Pro-inflammatory Markers and Heart Failure: A Systematic Literature Review and Meta-Analysis

Introduction: Surgical approaches to treat patients with abnormal pro-inflammatory parameters remain controversial, and the debate on the correlation between hematological parameter alteration in cardiac implantable electronic device (CIED) infection and the increase in mortality continues.Methods: We performed a systematic review using the PubMed, Scopus, and Cochrane Library databases. Twenty-two articles from May 2007 to April 2020 were selected and divided according to the following topics: prevalence of microbes in patients with CIED infection; characteristics of patients with CIED infection; comparison between patients who underwent and did not undergo replantation after device extraction; and correlation between alteration of hematological parameters and poor prognosis analysis.Results: Epidemiological analysis confirmed high prevalence of male sex, staphylococcal infection, and coagulase-negative staphylococci (CoNS). The most common comorbidity was heart failure. Complete removal of CIED and antimicrobial therapy combination are the gold standard. CIED replacement was associated with higher survival. High preoperative white blood cell count and C-reactive protein levels increased the risk of right ventricular failure (RVF) development. Increased red blood cell distribution width (RDW) value or decreased platelet count was correlated with poor prognosis. No correlation was noted between preoperative leukocytosis and CIED infection.Discussion: A relevant correlation between leukocytosis and RVF was observed. Heart failure may be related to high RDW values and decreased platelet count. Data on the correlation between hematological parameter alteration and poor prognosis are missing in many studies because of delayed implantation in patients showing signs of infection.