scholarly journals Downregulation of miR‑27b promotes skin wound healing in a rat model of scald burn by promoting fibroblast proliferation

2020 ◽  
Vol 20 (5) ◽  
pp. 1-1
Author(s):  
Qingxia Bi ◽  
Jingyan Liu ◽  
Xueming Wang ◽  
Furong Sun
Keyword(s):  
Wound Healing ◽  
Rat Model ◽  
Skin Wound ◽  
Fibroblast Proliferation ◽  
Skin Wound Healing

Application of acellular intima from porcine thoracic aorta in full-thickness skin wound healing in a rat model

2017 ◽  
Vol 71 ◽  
pp. 1135-1144 ◽  
Author(s):  
Haitian Fu ◽  
Liping Teng ◽  
RuiZhen Bai ◽  
Chao Deng ◽  
Guozhong Lv ◽  
...  
Keyword(s):  
Wound Healing ◽  
Thoracic Aorta ◽  
Rat Model ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Improvement of skin wound healing in diabetic mice by kinin B2 receptor blockade

2015 ◽  
Vol 130 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Dorinne Desposito ◽  
Catherine Chollet ◽  
Christopher Taveau ◽  
Vincent Descamps ◽  
François Alhenc-Gelas ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mouse Models ◽  
Receptor Activation ◽  
Skin Wound ◽  
Receptor Blockade ◽  
Fibroblast Proliferation ◽  
Diabetic Mice ◽  
Skin Wound Healing ◽  
Normal Wound Healing

Kinin B2 receptor activation impairs skin wound healing in mice, in part through imbalance of keratinocyte/fibroblast proliferation. Such activation occurs in diabetes and contributes to delaying wound healing. B2 receptor blockade restores the normal wound healing pattern in mouse models of diabetes.

scholarly journals Platelet rich plasma–complexed hydrogel glue enhances skin wound healing in a diabetic rat model

BIOCELL ◽  
2022 ◽  
Vol 46 (5) ◽  
pp. 1329-1338
Author(s):  
YUNLONG ZHANG ◽  
JINGWEI ZHANG ◽  
YU ZHU ◽  
BIN CAI
Keyword(s):  
Wound Healing ◽  
Rat Model ◽  
Platelet Rich Plasma ◽  
Skin Wound ◽  
Diabetic Rat ◽  
Skin Wound Healing ◽  
Diabetic Rat Model

Effects of the led therapy on the global DNA methylation and the expression of Dnmt1 and Dnmt3a genes in a rat model of skin wound healing

2016 ◽  
Vol 31 (7) ◽  
pp. 1521-1526 ◽  
Author(s):  
Marcus Vinícius de Matos Gomes ◽  
Marcelo Henrique Manfredo ◽  
Leandro Vaz Toffoli ◽  
Daniellen Christine Castro-Alves ◽  
Lucas Magnoni do Nascimento ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wound Healing ◽  
Rat Model ◽  
Skin Wound ◽  
Global Dna Methylation ◽  
Skin Wound Healing ◽  
Led Therapy

scholarly journals The Nf1 Tumor Suppressor Regulates Mouse Skin Wound Healing, Fibroblast Proliferation, and Collagen Deposited by Fibroblasts

1999 ◽  
Vol 112 (6) ◽  
pp. 835-842 ◽  
Author(s):  
Radhika P. Atit ◽  
Maria J. Crowe ◽  
David G. Greenhalgh ◽  
Richard J. Wenstrup ◽  
Nancy Ratner
Keyword(s):  
Wound Healing ◽  
Tumor Suppressor ◽  
Mouse Skin ◽  
Skin Wound ◽  
Fibroblast Proliferation ◽  
Skin Wound Healing

scholarly journals Overexpression of the Oral Mucosa-Specific microRNA-31 Promotes Skin Wound Closure

2019 ◽  
Vol 20 (15) ◽  
pp. 3679 ◽  
Author(s):  
Lin Chen ◽  
Alyne Simões ◽  
Zujian Chen ◽  
Yan Zhao ◽  
Xinming Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
Wound Closure ◽  
Expression Patterns ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Specific Expression ◽  
Keratinocyte Proliferation

Wounds within the oral mucosa are known to heal more rapidly than skin wounds. Recent studies suggest that differences in the microRNAome profiles may underlie the exceptional healing that occurs in oral mucosa. Here, we test whether skin wound-healing can be accelerating by increasing the levels of oral mucosa-specific microRNAs. A panel of 57 differentially expressed high expresser microRNAs were identified based on our previously published miR-seq dataset of paired skin and oral mucosal wound-healing [Sci. Rep. (2019) 9:7160]. These microRNAs were further grouped into 5 clusters based on their expression patterns, and their differential expression was confirmed by TaqMan-based quantification of LCM-captured epithelial cells from the wound edges. Of these 5 clusters, Cluster IV (consisting of 8 microRNAs, including miR-31) is most intriguing due to its tissue-specific expression pattern and temporal changes during wound-healing. The in vitro functional assays show that ectopic transfection of miR-31 consistently enhanced keratinocyte proliferation and migration. In vivo, miR-31 mimic treatment led to a statistically significant acceleration of wound closure. Our results demonstrate that wound-healing can be enhanced in skin through the overexpression of microRNAs that are highly expressed in the privileged healing response of the oral mucosa.

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