Gleditsia sinensis fruit extract induced growth inhibition involves basic fibroblast growth factor and nitric oxide

2004 ◽  
Author(s):  
Chung Chui ◽  
Johnny Tang ◽  
Fung Lau ◽  
Ivy Teo ◽  
Mable Yau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Growth Inhibition ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fruit Extract ◽  
Gleditsia Sinensis

Nitric Oxide Production Stimulated by the Basic Fibroblast Growth Factor Requires the Synthesis of Ceramide

2002 ◽  
Vol 973 (1) ◽  
pp. 94-104 ◽  
Author(s):  
SARA ARENA ◽  
ALESSANDRA PATTAROZZI ◽  
STEFANO THELLUNG ◽  
VALENTINA VILLA ◽  
ALESSANDRO CORSARO ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Nitric Oxide Production ◽  
Fibroblast Growth ◽  
Oxide Production

Migraine to the Year 2000

Cephalalgia ◽  
1995 ◽  
Vol 15 (4) ◽  
pp. 259-264 ◽  
Author(s):  
M Sandler
Keyword(s):  
Nitric Oxide ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Neurotrophic Factor ◽  
Normal Subjects ◽  
Fibroblast Growth ◽  
Migraine Aura ◽  
Year 2000

Although migraine is inextricably bound up with 5-hydroxytryptamine and its many receptors, its precise mechanisms continue to elude us and there is still no clear evidence supporting either a vascular or neurogenic hypothesis unequivocally. What appears to distinguish migraine sufferers from normal subjects may be a greater genetic sensitivity to a wide variety of triggering agents-even including nitric oxide and the migraine aura, as well as those more usually recognized. Attention is drawn to a possible role for neurotrophins, such as the hyperalgesia-provoking nerve growth factor (NGF) in particular, as well as basic fibroblast growth factor (bFGF) and brain-derived neurotrophic factor (BDNF).

Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats

2003 ◽  
Vol 285 (3) ◽  
pp. H1190-H1197 ◽  
Author(s):  
Sunita Srivastava ◽  
Ronald L. Terjung ◽  
H. T. Yang
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Spontaneously Hypertensive Rats ◽  
High Dose ◽  
Fibroblast Growth ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Calf Muscles

Ischemia-induced angiogenic response is reduced in spontaneously hypertensive rats (SHR). To study whether exogenous basic fibroblast growth factor (bFGF) infusion is effective in expanding collateral circulation in frankly hypertensive SHR, femoral arteries of male SHR (weighing ∼250 g) were kept intact (nonoccluded control; n = 9) or occluded for4h( n = 12) or for 16 days with vehicle ( n = 14) or bFGF [0.5 ( n = 17), 5.0 ( n = 13), and 50.0 ( n = 14) μg · kg–1 · day–1 for 14 days] intraarterially. Maximal collateral-dependent blood flows (BF) to the hindlimbs were determined with 85Sr- and 141Ce-labeled microspheres during running at 20 and 25 m/min (15% grade). Preexercise heart rates (∼530 beats/min) and blood pressures (BP; ∼200 mmHg) were similar across groups except in the high-dose bFGF group, where BP was reduced by ∼12% ( P < 0.05). Femoral artery occlusion for 4 h resulted in ∼95% reduction of BF in calf muscles [199 ± 18.7 (nonoccluded group) to 10 ± 1.0 ml · min–1 · 100 g–1; P < 0.001]. BF to calf muscles of the vehicle and low-dose bFGF (0.5 μg · kg–1 · day–1) groups increased to 36 ± 3.2 and 45 ± 2.0 ml · min–1 · 100 g–1, respectively ( P < 0.001). bFGF infusion at 5.0 and 50.0 μg · kg–1 · day–1 further increased ( P < 0.001) BF to calf muscles (62 ± 4.6 and 62 ± 2.2 ml · min–1 · 100 g–1, respectively). Our results show that bFGF can effectively increase BF in hypertensive rats. The reduced hypertension with high-dose bFGF suggests that a critical signal in arteriogenesis (nitric oxide bioavailability) may be restored. These findings suggest that the dulled endothelial nitric oxide synthase of SHR does not preempt collateral vessel remodeling.

In vivo angiogenesis in normal and portal hypertensive rats: role of basic fibroblast growth factor and nitric oxide

2001 ◽  
Vol 34 (5) ◽  
pp. 644-650 ◽  
Author(s):  
Cornel C Sieber ◽  
Lazar T Sumanovski ◽  
Michael Stumm ◽  
Maaike van der Kooij ◽  
Edouard Battegay
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Hypertensive Rats
Sign in / Sign up

Export Citation Format

Share Document