scholarly journals Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in vitro via interactions with the transcription factor Sp3

2016 ◽  
Vol 38 (5) ◽  
pp. 1474-1480 ◽  
Author(s):  
Yiling Cai ◽  
Mengting Yi ◽  
Dajun Chen ◽  
Jingjing Liu ◽  
Bayasi Guleng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Trefoil Factor ◽  
Cancer Cell Growth ◽  
Trefoil Factor Family

Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway

2013 ◽  
Vol 337 (2) ◽  
pp. 293-300 ◽  
Author(s):  
Shuai Wu ◽  
Xin-Yuan Lao ◽  
Tian-Tian Sun ◽  
Lin-Lin Ren ◽  
Xuan Kong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Mapk Pathway ◽  
Cancer Cell Growth ◽  
Erk Mapk

scholarly journals DAB2IP Downregulation Enhances the Proliferation and Metastasis of Human Gastric Cancer Cells by Derepressing the ERK1/2 Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Liang Sun ◽  
Yizhou Yao ◽  
Ting Lu ◽  
Zengfu Shang ◽  
Shenghua Zhan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Cancer Cell Growth ◽  
Normal Tissues

DAB2IP (DOC2/DAB2 interactive protein) is downregulated in several cancer types, and its downregulation is involved in tumor cell proliferation, apoptosis, metastasis, and epithelial-mesenchymal transition (EMT). We aimed to investigate the potential role of DAB2IP in the development and progression of gastric cancer. DAB2IP levels were analyzed in human gastric cancer and adjacent normal tissues by Western blots and immunohistochemistry. Potential roles of DAB2IP in regulating gastric cancer cell growth and metastasis were examined by genetic manipulation in vitro. The molecular signaling was determined to understand the mechanisms of observed DAB2IP effects. DAB2IP level is lower in gastric cancer tissues as compared to paired normal tissues. Knockdown of DAB2IP enhanced gastric cancer cell growth and metastasis in vitro and promoted EMT progress at both protein and mRNA levels. Silencing DAB2IP activated extracellular signal-regulated kinase 1/2 (ERK1/2) pathway, and the enhanced proliferation and migration ability induced by DAB2IP knockdown were reduced after incubation with U0126 in SGC7901 gastric cancer cells. Inhibition of DAB2IP enhances gastric cancer cell growth and metastasis through targeting the ERK1/2 signaling, indicating that it may serve as a potential target for treatment of gastric cancer.

Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro

2014 ◽  
Vol 59 (7) ◽  
pp. 1428-1435 ◽  
Author(s):  
Xiao-Ning Yang ◽  
Ya-Pi Lu ◽  
Jing-Jing Liu ◽  
Jian-Kun Huang ◽  
Yun-Peng Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Binding Protein ◽  
Trefoil Factor ◽  
Cell Mobility ◽  
Trefoil Factor Family

scholarly journals Role of CD4+CD25+ Regulatory T Cells in Melatonin-Mediated Inhibition of Murine Gastric Cancer Cell Growth In Vivo and In Vitro

2011 ◽  
Vol 294 (5) ◽  
pp. 781-788 ◽  
Author(s):  
Hui Liu ◽  
Li Xu ◽  
Jian-En Wei ◽  
Mei-Rong Xie ◽  
Shi-E Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Cell Growth ◽  
Regulatory T Cells ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth

Vitamin D suppressed gastric cancer cell growth through downregulating CD44 expression in vitro and in vivo

Nutrition ◽  
2021 ◽  
pp. 111413
Author(s):  
Qianxiu Li ◽  
Yifan Li ◽  
Houxiang Jiang ◽  
Zhangang Xiao ◽  
Xu Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vitamin D ◽  
Cell Growth ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth ◽  
Cd44 Expression

Downregulation of ornithine decarboxylase by pcDNA-ODCr inhibits gastric cancer cell growth in vitro

2010 ◽  
Vol 38 (2) ◽  
pp. 949-955 ◽  
Author(s):  
Chun-xiao Xu ◽  
Yun-fei Yan ◽  
Ya-pei Yang ◽  
Bin Liu ◽  
Jia-xuan Xin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Ornithine Decarboxylase ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth
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