Gene expression of neuropeptide Y and neuropeptide-Y1 receptor in relation to proto-oncogene tyrosine kinase A, nerve-growth-factor low-affinity-receptor and the transcription factor N-myc in human neuroblastomas

1996 ◽  
Author(s):  
J Hanze ◽  
H Christiansen ◽  
D Schuler ◽  
S Worgall ◽  
F Lampert ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Neuropeptide Y ◽  
Nerve Growth ◽  
Y1 Receptor ◽  
Affinity Receptor ◽  
Kinase A

scholarly journals Role of Nerve Growth Factor (NGF) and Its Receptor Tyrosine Kinase A (TrK A) in Egyptian Cirrhotic Patients with Pruritus

2018 ◽  
Vol 08 (09) ◽  
pp. 317-326
Author(s):  
Amr Zaghloul ◽  
Hanan Assaf ◽  
Reham Ezz ◽  
Mohamed Malak ◽  
Mahmoud Rezk ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Nerve Growth ◽  
Cirrhotic Patients ◽  
Trk A ◽  
Kinase A

Molecular Cloning, Expression, and Characterization of Rat Homolog of Human AP-2α That Stimulates Neuropeptide Y Transcription Activity in Response to Nerve Growth Factor

2000 ◽  
Vol 14 (6) ◽  
pp. 837-847
Author(s):  
Bing-Sheng Li ◽  
Phillip R. Kramer ◽  
Weiqin Zhao ◽  
Wu Ma ◽  
David A. Stenger ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neuropeptide Y ◽  
Nuclear Protein ◽  
Nerve Growth ◽  
Transcription Activity ◽  
Promoter Gene ◽  
Human Transcription Factor

Abstract Neuropeptide Y (NPY) plays an important role in the central regulation of neuronal activity, endocrine and sexual behavior, and food intake. Although transcription activity of the NPY gene in PC12 cells is regulated by a number of agents such as nerve growth factor (NGF), the mechanism responsible for the NGF-elicited increase in the transcription of the NPY gene remains to be explored. In this study, we isolated and characterized a nuclear protein that is bound to NGF-response elements (NGFRE) that lie between nucleotide −87 and −33 of the rat NPY promoter gene. This nuclear protein is identical to the rat homolog of human transcription factor AP-2α. We further demonstrated that rat AP-2α promotes efficient NPY transcription activity in response to NGF. Finally, we provide direct evidence that the mice lacking transcription factor AP-2α exhibit reduced expression of NPY mRNA compared with wild-type mice, further supporting the hypothesis that AP-2α is an important transcription factor in regulating NPY transcription activity.

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