scholarly journals Erlotinib for elderly patients with non-small-cell lung cancer: Subset analysis from a population-based observational study by the Ibaraki Thoracic Integrative (POSITIVE) Research Group

2013 ◽  
Vol 1 (5) ◽  
pp. 828-832 ◽  
Author(s):  
KOICHI KURISHIMA ◽  
HIROAKI SATOH ◽  
TAKAYUKI KABURAGI ◽  
YOSHIHIRO NISHIMURA ◽  
YOKO SHINOHARA ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Observational Study ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Research Group ◽  
Population Based ◽  
Small Cell ◽  
Small Cell Lung ◽  
Positive Research

Phase I/II trial of gemcitabine plus oral TS-1 in elderly patients with advanced non-small cell lung cancer: Thoracic oncology research group study 0502

Lung Cancer ◽  
2010 ◽  
Vol 69 (2) ◽  
pp. 213-217 ◽  
Author(s):  
Takashi Seto ◽  
Takeharu Yamanaka ◽  
Izumi Wasada ◽  
Nobuhiko Seki ◽  
Hiroaki Okamoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Phase I ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Research Group ◽  
Small Cell ◽  
Small Cell Lung ◽  
Oncology Research

Impact of Introducing Stereotactic Lung Radiotherapy for Elderly Patients With Stage I Non–Small-Cell Lung Cancer: A Population-Based Time-Trend Analysis

2010 ◽  
Vol 28 (35) ◽  
pp. 5153-5159 ◽  
Author(s):  
David Palma ◽  
Otto Visser ◽  
Frank J. Lagerwaard ◽  
Jose Belderbos ◽  
Ben J. Slotman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Elderly Patients ◽  
Small Cell Lung Cancer ◽  
Cancer Registry ◽  
Cell Lung Cancer ◽  
Population Based ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
The Impact

Purpose Stereotactic body radiotherapy (SBRT) for stage I non–small-cell lung cancer (NSCLC) is associated with high local control rates. The impact of introducing SBRT in patients 75 years of age or older was studied using a population-based cancer registry. Methods The Amsterdam Cancer Registry was assessed in three eras: 1999 to 2001 (period A, pre-SBRT); 2002 to 2004 (period B, some availability of SBRT), and 2005 to 2007 (period C, full access to SBRT). χ2, Kaplan-Meier, and Cox regression were used to compare treatment patterns and overall survival (OS) in three treatment groups: surgery, radiotherapy (RT), or neither. Results A total of 875 elderly patients were diagnosed with stage I NSCLC in the study period. Median follow-up was 54 months. Primary treatment was surgery in 299 patients (34%), RT in 299 patients (34%), and neither in 277 patients (32%). RT use increased between periods A and C (26% v 42%, P < .01), corresponding to a decrease in untreated patients. The percentage of RT patients undergoing SBRT in periods B and C was 23% and 55%, respectively. Median survival for all patients increased from 16 months in period A to 21 months in period C (log-rank P < .01; hazard ratio [HR] = 0.65; 95% CI, 0.54 to 0.80). The improvement in OS was confined to RT patients (HR = 0.70; 95% CI, 0.49 to 0.99), whereas no significant survival improvements were seen in the other groups. Conclusion SBRT introduction was associated with a 16% absolute increase in RT use, a decline in the proportion of untreated elderly patients, and an improvement in OS.

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