scholarly journals Resveratrol improves urinary dysfunction in rats with chronic prostatitis and suppresses the activity of the stem cell factor/c-Kit signaling pathway

2017 ◽  
Vol 16 (2) ◽  
pp. 1395-1400 ◽  
Author(s):  
Yang Yu ◽  
Jiang Jiang ◽  
Yi He ◽  
Wei Wang ◽  
Chen Shen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Chronic Prostatitis ◽  
Urinary Dysfunction ◽  
Factor C

scholarly journals Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway

Blood ◽  
2002 ◽  
Vol 100 (4) ◽  
pp. 1274-1286 ◽  
Author(s):  
Jesus Pérez-Losada ◽  
Manuel Sánchez-Martı́n ◽  
Arancha Rodrı́guez-Garcı́a ◽  
Maria Luz Sánchez ◽  
Alberto Orfao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Bone Marrow Cells ◽  
Surface Expression ◽  
Mutant Mice ◽  
Intrinsic Defect ◽  
Snail Family ◽  
Cell Mobilization ◽  
Factor C

The stem cell factor c-kit signaling pathway (SCF/c-kit) has been previously implicated in normal hematopoiesis, melanogenesis, and gametogenesis through the formation and migration of c-kit+ cells. These biologic functions are also determinants in epithelial–mesenchymal transitions during embryonic development governed by the Snail family of transcription factors. Here we show that the activation of c-kit by SCF specifically induces the expression of Slug, a Snail family member. Slug mutant mice have a cell-intrinsic defect with pigment deficiency, gonadal defect, and impairment of hematopoiesis. Kit+ cells derived from Slug mutant mice exhibit migratory defects similar to those of c-kit+ cells derived from SCF and c-kit mutant mice. Endogenous Slug is expressed in migratory c-kit+ cells purified from control mice but is not present in c-kit+cells derived from SCF mutant mice or in bone marrow cells from W/Wv mice, though Slug is present in spleen c-kit+ cells of W/Wv (mutants expressing c-kit with reduced surface expression and activity). SCF-induced migration was affected in primary c-kit+ cells purified from Slug−/− mice, providing evidence for a role of Slug in the acquisition of c-kit+ cells with ability to migrate. Slug may thus be considered a molecular target that contributes to the biologic specificity to the SCF/c-kit signaling pathway, opening up new avenues for stem cell mobilization.

Activation Of Stem Cell Factor/c-Kit Signaling Pathway In Pulmonary Fibrosis

2010 ◽  
Author(s):  
Lin Ding ◽  
Zhuang Wu ◽  
Tianju Liu ◽  
Matthew Ullenbruch ◽  
Jianhua Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pulmonary Fibrosis ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Factor C

Expression of stem cell factor/c-kit signaling pathway components in diabetic fibrovascular epiretinal membranes

2010 ◽  
Vol 88 ◽  
pp. 0-0 ◽  
Author(s):  
A ABU EL ASRAR ◽  
S STRUYF ◽  
G OPDENAKKER ◽  
J VAN DAMME ◽  
K GEBOES
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Epiretinal Membranes ◽  
Factor C

scholarly journals Atractylenolide‑1 alleviates gastroparesis in diabetic rats by activating the stem cell factor/c‑kit signaling pathway

2021 ◽  
Vol 24 (4) ◽  
Author(s):  
Hui Li ◽  
Wen Cao ◽  
Xun-Bin Zhang ◽  
Xi-Xia Zhang ◽  
Chao Gu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Diabetic Rats ◽  
Factor C

scholarly journals Induction of Stem Cell Factor/c-Kit/Slug Signal Transduction in Multidrug-resistant Malignant Mesothelioma Cells

2004 ◽  
Vol 279 (45) ◽  
pp. 46706-46714 ◽  
Author(s):  
Alfonso Catalano ◽  
Sabrina Rodilossi ◽  
Maria Rita Rippo ◽  
Paola Caprari ◽  
Antonio Procopio
Keyword(s):  
Signal Transduction ◽  
Stem Cell ◽  
Malignant Mesothelioma ◽  
Stem Cell Factor ◽  
Multidrug Resistant ◽  
Factor C

Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors

Cytokine ◽  
2013 ◽  
Vol 61 (1) ◽  
pp. 329-335 ◽  
Author(s):  
Renaud Geslain ◽  
Shahab Uddin ◽  
Hui Liu ◽  
Hongmei Jiang ◽  
Koen van Besien ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Kinase Signaling ◽  
Erythroid Progenitors ◽  
Mtor Kinase ◽  
Kinase Signaling Pathway

A6010 The relationship between hypertension and stem cell factor/c-kit in depressive patients

2018 ◽  
Vol 36 ◽  
pp. e294-e295
Author(s):  
Muhammad Nabeel Dookhun ◽  
Hai-Lan Zhong ◽  
Ya-Li Sun ◽  
Xiao-Qian Cao ◽  
Hua-Yi Yang Zou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Factor ◽  
Factor C ◽  
The Relationship ◽  
Depressive Patients

Anti-Müllerian Hormone Regulates Stem Cell Factor via cAMP/PKA Signaling Pathway in Human Granulosa Cells by Inhibiting the Phosphorylation of CREB

2020 ◽  
Vol 27 (1) ◽  
pp. 325-333
Author(s):  
Yun-Xing Fu ◽  
Fei-Miao Wang ◽  
Xiao-E Ou-yang ◽  
Hui-Min Yang ◽  
Ting Hu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Granulosa Cells ◽  
Stem Cell Factor ◽  
Human Granulosa Cells

Effect of stem cell factor (c-kit ligand) on clonogenic leukemic precursor cells: Synergy with other hematopoietic growth factors

1994 ◽  
Vol 47 (4) ◽  
pp. 328-330 ◽  
Author(s):  
Hua-Kang Wu ◽  
Shigeru Chiba ◽  
Hisamaru Hirai ◽  
Fumimaro Takaku ◽  
Yoshio Yazaki
Keyword(s):  
Stem Cell ◽  
Growth Factors ◽  
Stem Cell Factor ◽  
Precursor Cells ◽  
Hematopoietic Growth Factors ◽  
Kit Ligand ◽  
Factor C
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