Increased soluble ST2 and IL‑4 serum levels are associated with disease severity in patients with membranous nephropathy

Abstract Background The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical ventilation. Such variability stresses the need for novel biomarkers associated with disease outcome. As SARS-CoV-2 infection causes a kidney proximal tubule dysfunction with urinary loss of uric acid, we hypothesized that low serum levels of uric acid (hypouricemia) may be associated with severity and outcome of COVID-19. Methods In a retrospective study using two independent cohorts, we investigated and validated the prevalence, kinetics and clinical correlates of hypouricemia among patients hospitalized with COVID-19 to a large academic hospital in Brussels, Belgium. Survival analyses using Cox regression and a competing risk approach assessed the time to mechanical ventilation and/or death. Confocal microscopy assessed the expression of urate transporter URAT1 in kidney proximal tubule cells from patients who died from COVID-19. Results The discovery and validation cohorts included 192 and 325 patients hospitalized with COVID-19, respectively. Out of the 517 patients, 274 (53%) had severe and 92 (18%) critical COVID-19. In both cohorts, the prevalence of hypouricemia increased from 6% upon admission to 20% within the first days of hospitalization for COVID-19, contrasting with a very rare occurrence (< 1%) before hospitalization for COVID-19. During a median (interquartile range) follow-up of 148 days (50–168), 61 (12%) patients required mechanical ventilation and 93 (18%) died. In both cohorts considered separately and in pooled analyses, low serum levels of uric acid were strongly associated with disease severity (linear trend, P < 0.001) and with progression to death and respiratory failure requiring mechanical ventilation in Cox (adjusted hazard ratio 5.3, 95% confidence interval 3.6–7.8, P < 0.001) or competing risks (adjusted hazard ratio 20.8, 95% confidence interval 10.4–41.4, P < 0.001) models. At the structural level, kidneys from patients with COVID-19 showed a major reduction in urate transporter URAT1 expression in the brush border of proximal tubules. Conclusions Among patients with COVID-19 requiring hospitalization, low serum levels of uric acid are common and associate with disease severity and with progression to respiratory failure requiring invasive mechanical ventilation.

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Reply: “IFN‐α and TNF‐α serum levels and their association with disease severity in Egyptian children and adults with alopecia areata”

International Journal of Dermatology ◽

10.1111/ijd.15899 ◽

2021 ◽

Author(s):

Vikram N. Sahni ◽

Aishwarya Suresh ◽

Dev R. Sahni ◽

Jason G. Mathis

Keyword(s):

Disease Severity ◽

Alopecia Areata ◽

Serum Levels ◽

Tnf Α ◽

Egyptian Children

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Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve

Endocrine ◽

10.1007/s12020-018-1811-1 ◽

2018 ◽

Vol 63 (2) ◽

pp. 405-405

Author(s):

Clara Di Mario ◽

Luca Petricca ◽

Maria Rita Gigante ◽

Angelina Barini ◽

Antonella Barini ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Severity ◽

Ovarian Reserve ◽

Lupus Erythematosus ◽

Serum Levels ◽

Systemic Lupus

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Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: Influence of the disease severity and therapy on the ovarian reserve

Endocrine ◽

10.1007/s12020-018-1783-1 ◽

2018 ◽

Vol 63 (2) ◽

pp. 369-375 ◽

Cited By ~ 6

Author(s):

Clara Di Mario ◽

Luca Petricca ◽

Maria Rita Gigante ◽

Angelina Barini ◽

Antonella Barini ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Severity ◽

Ovarian Reserve ◽

Lupus Erythematosus ◽

Serum Levels ◽

Systemic Lupus

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Comparison of the Serum Levels of Interferon-α in the Patients With Crimean-Congo Hemorrhagic Fever Based on Disease Severity

International journal of basic science in medicine ◽

10.15171/ijbsm.2016.13 ◽

2016 ◽

Vol 1 (2) ◽

pp. 58-62

Author(s):

Maliheh Metanat ◽

Masoud Salehi ◽

Anita Ale Nabi ◽

Masoume Noori Jangi ◽

Alireza Noori Jangi ◽

...

Keyword(s):

Disease Severity ◽

Hemorrhagic Fever ◽

Serum Levels ◽

Interferon Α ◽

Crimean Congo Hemorrhagic Fever

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Serum levels of CXCL-8, IL-10, and TNF-alpha in ankylosing spondylitis patients

Biomedicine ◽

10.51248/.v41i3.775 ◽

2021 ◽

Vol 41 (3) ◽

Author(s):

Dhuha Karim

Keyword(s):

Disease Severity ◽

Functional Disability ◽

White Blood Cells ◽

Age Groups ◽

Area Under The Curve ◽

Serum Levels ◽

Hla B27 ◽

Diagnostic Significance ◽

Significant Difference ◽

Wbc Count

The mean age of AS patients was (35.0 ± 9.8) years.When the patients and control subjects were divided into different age groups (>40, 30-40, <30 years), the differences were not significantin terms of disease prevalence. The results also showed that the percentage of male patients is higher than that of females. There was no significant difference (P?0.05) between patients and controls in the distribution of males and females.Most of the patients had the disease for a period of 5 years or higher, with a disease severity of ? 2.1 and functional disability degree of I, II. The resultsshoweddifferent patterns of distribution for the three tested cytokines. A significant increase in the level of TNF-?, anon-significantincrease in the level of CXCL-8, and a significant decrease in the level of IL-10 were observed in the sera of patients with AS compared with the control.The patients also demonstrated significant decreases in the serum ALT and AST enzyme levels, hemoglobin (Hb) level, white blood cells (WBC) count, and erythrocyte sedimentation rate (ESR) (P?0.05).The percentage of HLA-B27-positive Iraqi patients was lower than that of the HLA-B27-negative patients. Some of these patterns were also exposed to changes related to some determinants in patients, which included age, sex, disease duration, disease severity, functional disability, and HLA-B27 positivity,along with association with clinical subtypes of AS.The area under the curve was determined for the parameters of ESR, IL-10, TNF-? and CXCL-8.The most significant factor was found to beESR, followed by IL-10, and then TNF-?, with the presence of significant differences, while there was no diagnostic significance for CXCL-8 ,which showed no significant difference (p?0.05).

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