scholarly journals Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis

2012 ◽  
Vol 3 (5) ◽  
pp. 983-989 ◽  
Author(s):  
KENSUKE KUMAMOTO ◽  
KOKI KUWABARA ◽  
YUSUKE TAJIMA ◽  
KUNIHIKO AMANO ◽  
SATOSHI HATANO ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Mrna Expression ◽  
Cancer Patients ◽  
Thymidylate Synthase ◽  
Laser Capture Microdissection ◽  
Thymidine Phosphorylase ◽  
Colorectal Cancer Patients ◽  
Laser Capture

Evaluation of thymidylate synthase and ERCC1 mRNA levels as predictive markers in colorectal cancer patients treated with S-1 and oxaliplatin

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15071-e15071
Author(s):  
H. Kuramochi ◽  
K. Hayashi ◽  
G. Nakajima ◽  
H. Kamikozuru ◽  
M. Yamamoto
Keyword(s):  
Colorectal Cancer ◽  
Mrna Expression ◽  
Real Time ◽  
Cancer Patients ◽  
Thymidylate Synthase ◽  
Excision Repair ◽  
Mrna Levels ◽  
Expression Levels ◽  
Colorectal Cancer Patients ◽  
Mrna Expression Levels

e15071 Background: Oxaliplatin has been widely used for the treatment of colorectal cancer. The mechanism of action of platinum compounds such as oxaliplatin is to bind to a DNA molecule in the form of a platinum-DNA-adduct. Excision repair cross complementation group 1 (ERCC1), which plays a major role in the nucleotide excision pathway, has a polymorphism in codon 118, and is reported to be associated with a resistance to platinum-based therapy. Thymidylate synthase (TS) and dehydropyrimidine dehydrogenase (DPD) are key enzymes of 5-FU metabolism and are well known to be associated with a response to 5-FU-based therapy. Methods: Twenty-one colorectal cancer patients (male:female = 7:14; median age, 65) treated with a combination of oxaliplatin and S-1 as a first-line therapy were analyzed for ERCC1 codon 118 polymorphism and the mRNA expression levels of TS, ERCC1, and DPD. Formalin-fixed paraffin- embedded surgical specimens were used and t-RNA and DNA were extracted. The mRNA expression levels were measured using real-time RT-PCR, and the polymorphism was analyzed using the allelic discrimination method together with real-time PCR. Results: No correlation was observed between ERCC1 codon118 polymorphism and any response to the chemotherapy. ERCC1 mRNA levels tended to be higher in the patients with wild-type homozygous alleles in codon 118 than in those with at least one mutant allele(1.19 vs.0.68: p= 0.15). Patients with both high TS and ERCC1 mRNA levels showed a significantly lower response rate than the others (25% vs. 67%, p=0.02). No relationship was seen between DPD mRNA expression levels and the response. Conclusions: The mRNA expression levels of TS and ERCC1 appear to be useful markers for the treatment of S-1 and oxaliplatin. No particular usefulness of ERCC1 codon 118 polymorphism was verified. No significant financial relationships to disclose.

scholarly journals Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2418
Author(s):  
Xuezhen Zeng ◽  
Simon E. Ward ◽  
Jingying Zhou ◽  
Alfred S. L. Cheng
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
High Recurrence Rate ◽  
Immune Microenvironment ◽  
Liver Sinusoidal Endothelial Cells ◽  
Premetastatic Niche ◽  
Cancer Pathogenesis ◽  
Colorectal Cancer Patients ◽  
The Impact

A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized cancer and distal organ metastasis. The liver is the most favorable organ for cancer metastases from the colorectum. Beyond the liver-colon anatomic relationship, emerging evidence highlights the impact of liver immune microenvironment on colorectal liver metastasis. Prior to cancer cell dissemination, hepatocytes secrete multiple factors to recruit or activate immune cells and stromal cells in the liver to form a favorable premetastatic niche. The liver-resident cells including Kupffer cells, hepatic stellate cells, and liver-sinusoidal endothelial cells are co-opted by the recruited cells, such as myeloid-derived suppressor cells and tumor-associated macrophages, to establish an immunosuppressive liver microenvironment suitable for tumor cell colonization and outgrowth. Current treatments including radical surgery, systemic therapy, and localized therapy have only achieved good clinical outcomes in a minority of colorectal cancer patients with liver metastasis, which is further hampered by high recurrence rate. Better understanding of the mechanisms governing the metastasis-prone liver immune microenvironment should open new immuno-oncology avenues for liver metastasis intervention.

scholarly journals Analysis of the postoperative hemostatic profile of colorectal cancer patients subjected to liver metastasis resection surgery

2019 ◽  
Vol 7 (17) ◽  
pp. 2477-2486
Author(s):  
Guillermo Perez Navarro ◽  
Ana Maria Pascual Bellosta ◽  
Sonia María Ortega Lucea ◽  
Mario Serradilla Martín ◽  
Jose Manuel Ramirez Rodriguez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Colorectal Cancer Patients

Correlation between malignancy grade and p53 gene in relation to thymidine phosphorylase activity in colorectal cancer patients

2002 ◽  
Author(s):  
Tatsuya Aoki ◽  
Kenji Katsumata ◽  
Akihiko Tsuchida ◽  
Hidenori Tomioka ◽  
Yasuhisa Koyanagi
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Thymidine Phosphorylase ◽  
P53 Gene ◽  
Phosphorylase Activity ◽  
Malignancy Grade ◽  
Thymidine Phosphorylase Activity ◽  
Colorectal Cancer Patients

scholarly journals Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients

2015 ◽  
Vol 5 (4) ◽  
pp. e1101205 ◽  
Author(s):  
Pierpaolo Correale ◽  
Cirino Botta ◽  
Elodia Claudio Martino ◽  
Cristina Ulivieri ◽  
Giuseppe Battaglia ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Thymidylate Synthase ◽  
Peptide Vaccination ◽  
Epitope Peptide ◽  
Phase Ib ◽  
Colorectal Cancer Patients

scholarly journals Characterizations of DNA copy number variations and spatio-temporal intra tumor heterogeneity in liver metastasis from colorectal cancer patients

2018 ◽  
Vol 29 ◽  
pp. v93-v94
Author(s):  
M. Marques ◽  
K. Gambaro ◽  
M. Couetoux du Tertre ◽  
M. Witcher ◽  
B. Samson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Copy Number ◽  
Tumor Heterogeneity ◽  
Copy Number Variations ◽  
Dna Copy Number ◽  
Dna Copy Number Variations ◽  
Spatio Temporal ◽  
Colorectal Cancer Patients

The prognostic significance of resection of primary tumor in gastric and colorectal cancer patients with synchronous liver metastasis

1988 ◽  
Vol 18 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Kazuaki Okuyama ◽  
Shoichi Onoda ◽  
Noriyuki Tohnosu ◽  
Yoshikazu Yamamoto ◽  
Yoshio Koide ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Prognostic Significance ◽  
Synchronous Liver Metastasis ◽  
Colorectal Cancer Patients
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