Prognostic value of inflammation‑based indexes for intrahepatic cholangiocarcinoma following curative resection

Abstract Background Plasmacytoid dendritic cells (pDCs) are present in various primary and metastatic human neoplasms; however, their clinical significance in intrahepatic cholangiocarcinoma is not clear. Methods To evaluate pDCs’ distributions in and around tumors as well as their potential function and predictive value for prognosis in patients undergoing curative resection, we performed immunohistochemistry to examine the expression of pDC marker BDCA2, and CD3, CD4, CD8 and Foxp3 in intratumoral and peritumoral tissues from 359 patients with intrahepatic cholangiocarcinoma and compared with prognostic and clinicopathologic factors. Results Results showed that patients with high numbers of BDCA2+ pDCs in peritumoral tissues were more likely to have elevated levels of carbohydrate antigen 19-9 and gamma-glutamyl transferase, larger and more tumors, advanced tumor-node-metastasis staging, more vascular/bile duct invasion, and lymphatic metastasis in association with greater chance of recurrence and shorter overall survival. Peritumoral tissues with larger numbers of pDCs also showed increased Foxp3+ regulatory T cell infiltration, both of which were found to be independent factors for predicting time to recurrence and overall survival. By contrast, patient outcomes were not associated with the presence of intratumoral pDCs. Conclusions Peritumoral pDC infiltration may indicate an immune tolerogenic peritumor microenvironment and can be used to predict a poor prognosis for patients undergoing curative resection for intrahepatic cholangiocarcinoma.

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Perineural invasion as a prognostic factor for intrahepatic cholangiocarcinoma after curative resection and a potential indication for postoperative chemotherapy: a retrospective cohort study

BMC Cancer ◽

10.1186/s12885-020-06781-w ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Zeyu Zhang ◽

Yufan Zhou ◽

Kuan Hu ◽

Dong Wang ◽

Zhiming Wang ◽

...

Keyword(s):

Cohort Study ◽

Prognostic Factor ◽

Intrahepatic Cholangiocarcinoma ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Curative Resection ◽

Perineural Invasion ◽

Postoperative Chemotherapy

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Prognostic Value and Predication Model of Microvascular Invasion in Patients with Intrahepatic Cholangiocarcinoma

Journal of Cancer ◽

10.7150/jca.32199 ◽

2019 ◽

Vol 10 (22) ◽

pp. 5575-5584 ◽

Cited By ~ 1

Author(s):

Zheng Tang ◽

Wei-Ren Liu ◽

Pei-Yun Zhou ◽

Zhen-Bin Ding ◽

Xi-Fei Jiang ◽

...

Keyword(s):

Intrahepatic Cholangiocarcinoma ◽

Prognostic Value ◽

Microvascular Invasion

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Prognostic value of multiple epithelial mesenchymal transition‑associated proteins in intrahepatic cholangiocarcinoma

Oncology Letters ◽

10.3892/ol.2019.10522 ◽

2019 ◽

Author(s):

Xiangguo Tian ◽

Zhixin Cao ◽

Qian Ding ◽

Zhen Li ◽

Chunqing Zhang

Keyword(s):

Intrahepatic Cholangiocarcinoma ◽

Prognostic Value ◽

Epithelial Mesenchymal Transition ◽

Mesenchymal Transition ◽

Associated Proteins

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A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma

Journal of Immunology Research ◽

10.1155/2018/4925498 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 14

Author(s):

Qiaodong Xu ◽

Yongcong Yan ◽

Songgang Gu ◽

Kai Mao ◽

Jianlong Zhang ◽

...

Keyword(s):

Roc Curve ◽

Prognostic Value ◽

Curative Resection ◽

Operating Characteristic ◽

Curve Analysis ◽

Prognostic Scores ◽

Roc Curve Analysis ◽

Optimal Cutoff ◽

Albumin Ratio ◽

Cutoff Value

Background. Inflammation is an important hallmark of cancer. Fibrinogen and albumin are both vital factors in systemic inflammation. This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative resection. Methods. HCC patients (n=151) who underwent curative resection were evaluated retrospectively. The optimal cutoff value for the fibrinogen/albumin ratio was selected by receiver operating characteristic (ROC) curve analysis. Correlations between preoperative fibrinogen/albumin ratios and clinicopathologic characteristics were analyzed by χ2 test. The area under the receiver operating characteristic curve (AUC) was calculated to compare the prognostic value of the fibrinogen/albumin ratio with other prognostic scores (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and albumin-bilirubin (ALBI) score). The overall survival (OS) and time to recurrence (TTR) were assessed by the log-rank test and the Cox proportional hazard regression model. Results. An optimal cutoff value of the preoperative fibrinogen/albumin ratio (0.062) was determined for 151 patients who underwent curative resection for HCC via a ROC curve analysis. Fibrinogen/albumin ratio > 0.062 was significantly associated with microvascular invasion, an advanced BCLC stage, and ALBI grade. Multivariate analyses revealed that fibrinogen/albumin ratio was an independent predictor for OS (P=0.003) and TTR (P=0.035). The prognostic ability of fibrinogen/albumin ratio was comparable to other prognostic scores (NLR, PLR, and ALBI score) by AUC analysis. Patients with a fibrinogen/albumin ratio > 0.062 had lower 1-, 3-, and 5-year OS rates (66.0%, 41.8%, and 28.2% versus 81.9%, 69.3%, and 56.1%, resp., P<0.001) and higher 1-, 3-, and 5-year recurrence rates (60.9%, 79.2%, and 90.5% versus 49.5%, 69.1%, and 77.1%, resp., P=0.008) compared with patients with fibrinogen/albumin ratio ≤ 0.062. Conclusion. The preoperative fibrinogen/albumin ratio is an effective prognostic factor for HCC patients who underwent curative resection. An elevated fibrinogen/albumin ratio significantly correlates with poorer survival and a higher risk of recurrence in HCC patients.

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