Clinical significance of bromodomain‑containing protein 7 and its association with tumor progression in prostate cancer

Aims: To determine the role of lamin B1 (LMNB1) in the progression and metastasis of primary prostate cancer (PC). Patients & methods: Two PC cohorts were used to investigate the clinical relationship between LMNB1 expression and tumor progression and metastasis. Results: The qRT-PCR results revealed that LMNB1 expression was markedly increased in patients with aggressive features and was associated with worse prognosis. Logistic regression analyses indicated that LMNB1 expression is an independent risk factor for distant metastasis. Kaplan–Meier analysis showed that increased LMNB1 levels were related to poor disease-free survival in the primary PC cohort. Conclusion: This study reveals that upregulation of LMNB1 is associated with cancer metastasis and poor survival outcomes in primary PC patients.

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Cell Plasticity and Prostate Cancer: The Role of Epithelial–Mesenchymal Transition in Tumor Progression, Invasion, Metastasis and Cancer Therapy Resistance

Cancers ◽

10.3390/cancers13112795 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2795

Author(s):

Sofia Papanikolaou ◽

Aikaterini Vourda ◽

Spyros Syggelos ◽

Kostis Gyftopoulos

Keyword(s):

Prostate Cancer ◽

Cancer Therapy ◽

Tumor Progression ◽

Epithelial Mesenchymal Transition ◽

Metastatic Tumor ◽

Therapy Resistance ◽

Cellular Process ◽

Cell Plasticity ◽

Mesenchymal Transition

Prostate cancer, the second most common malignancy in men, is characterized by high heterogeneity that poses several therapeutic challenges. Epithelial–mesenchymal transition (EMT) is a dynamic, reversible cellular process which is essential in normal embryonic morphogenesis and wound healing. However, the cellular changes that are induced by EMT suggest that it may also play a central role in tumor progression, invasion, metastasis, and resistance to current therapeutic options. These changes include enhanced motility and loss of cell–cell adhesion that form a more aggressive cellular phenotype. Moreover, the reverse process (MET) is a necessary element of the metastatic tumor process. It is highly probable that this cell plasticity reflects a hybrid state between epithelial and mesenchymal status. In this review, we describe the underlying key mechanisms of the EMT-induced phenotype modulation that contribute to prostate tumor aggressiveness and cancer therapy resistance, in an effort to provide a framework of this complex cellular process.

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Total submission of lymphadenectomy tissues removed during radical prostatectomy for prostate cancer: possible clinical significance of large-format histology

Human Pathology ◽

10.1016/j.humpath.2014.06.023 ◽

2014 ◽

Vol 45 (10) ◽

pp. 2059-2062 ◽

Cited By ~ 5

Author(s):

Rodolfo Montironi ◽

Marina Scarpelli ◽

Andrea B. Galosi ◽

Antonio Lopez-Beltran ◽

Roberta Mazzucchelli ◽

...

Keyword(s):

Prostate Cancer ◽

Radical Prostatectomy ◽

Clinical Significance ◽

Large Format

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Clinical significance of pelvic lymph node status in prostate cancer: review of 1690 cases

Internal and Emergency Medicine ◽

10.1007/s11739-015-1375-5 ◽

2016 ◽

Vol 11 (3) ◽

pp. 399-404 ◽

Cited By ~ 5

Author(s):

Livia Maccio ◽

Valeria Barresi ◽

Federica Domati ◽

Eugenio Martorana ◽

Anna Maria Cesinaro ◽

...

Keyword(s):

Prostate Cancer ◽

Lymph Node ◽

Clinical Significance ◽

Pelvic Lymph Node ◽

Lymph Node Status ◽

Node Status ◽

Cancer Review

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2137 EXPRESSION OF ESTROGEN RELATED PROTEINS IN HORMONE-REFRACTORY PROSTATE CANCER: ASSOCIATION WITH TUMOR PROGRESSION

The Journal of Urology ◽

10.1016/j.juro.2010.02.2225 ◽

2010 ◽

Vol 183 (4S) ◽

Author(s):

Olivier Celhay ◽

Mokrane Yacoub ◽

Bertrand Doré ◽

Jacques Irani ◽

Olivier Cussenot ◽

...

Keyword(s):

Prostate Cancer ◽

Tumor Progression ◽

Hormone Refractory Prostate Cancer ◽

Hormone Refractory ◽

Related Proteins

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Clinical significance and risk factors of urethrovesical anastomotic urinary leakage following robot-assisted radical prostatectomy: a multi-institutional study

BMC Urology ◽

10.1186/s12894-021-00844-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shigenori Kakutani ◽

Yuta Takeshima ◽

Yuta Yamada ◽

Tetsuya Fujimura ◽

Shoichi Nagamoto ◽

...

Keyword(s):

Prostate Cancer ◽

Risk Factors ◽

Radical Prostatectomy ◽

Clinical Significance ◽

Final Analysis ◽

Urinary Continence ◽

Robot Assisted ◽

Urinary Leakage ◽

Postoperative Continence ◽

The University

Abstract Background There has been a limited number of reports on the significance and risk factors of urethrovesical anastomotic urinary leakage (AUL) following robot-assisted radical prostatectomy (RARP). We aimed to analyze the clinical significance of AUL and evaluated its risk factors. Methods We conducted a multi-institutional study to review patients with prostate cancer undergoing RARP in three centers (The University of Tokyo Hospital, Mitsui Memorial Hospital, and Chiba Tokushukai Hospital). “Positive AUL” was defined as urinary extravasation at the anastomosis detected by post-operative cystogram and was further categorized into minor or major AUL. Univariate and multivariate analyses were performed to identify predictors of AUL. Postoperative continence rates and time to achieve continence were also analyzed. Results A total of 942 patients underwent RARP for prostate cancer in 3 centers. Of these patients, a cystogram after the RARP procedure was not performed in 26 patients leaving 916 patients for the final analysis. AUL was observed in 56 patients (6.1%); 34 patients (3.7%) with minor AUL and 22 patients (2.4%) with major AUL. Patients with major AUL exhibited a significantly longer time to achieve continence than those without major AUL. Multivariate analysis demonstrated that longer console time (≥ 184 min) was significantly associated with overall AUL, and higher body mass index (≥ 25 g/kg2) was a significant predictor of both major and overall AUL. Conclusions The presence of major AUL was associated with the achievement of urinary continence, suggesting clinical relevance of its diagnosis by postoperative cystogram. A selective cystogram has been proposed for high-risk cases. Furthermore, identification of the risk factors of AUL will lead to optimal application.

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