scholarly journals Cytochrome�C inhibits tumor growth and predicts favorable prognosis in clear cell renal cell carcinoma

2019 ◽  
Author(s):  
Zhiguo Liu ◽  
Xiancheng Zhao ◽  
Liang Zhang ◽  
Bing Pei
Keyword(s):  
Renal Cell Carcinoma ◽  
Cytochrome C ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Favorable Prognosis

SOX6 represses tumor growth of clear cell renal cell carcinoma by HMG domain‐dependent regulation of Wnt/β‐catenin signaling

2020 ◽  
Vol 59 (10) ◽  
pp. 1159-1173
Author(s):  
Luyao Chen ◽  
Yongpeng Xie ◽  
Xin Ma ◽  
Yu Zhang ◽  
Xintao Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma

2013 ◽  
Vol 11 (11) ◽  
pp. 1375-1386 ◽  
Author(s):  
Hye Won Lee ◽  
Kyeung Min Joo ◽  
Joung Eun Lim ◽  
Hyun Jung Cho ◽  
Hee Jin Cho ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Tumor Growth And Metastasis

scholarly journals RUNX1/miR-582-5p Pathway Regulates the Tumor Progression in Clear Cell Renal Cell Carcinoma by Targeting COL5A1

2021 ◽  
Vol 11 ◽  
Author(s):  
Jianxin Xue ◽  
Shenhao Zhu ◽  
Feng Qi ◽  
Kai Zhu ◽  
Pu Cao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Negative Regulator ◽  
Expression Level ◽  
Cell Renal Cell Carcinoma

Recent evidences indicated that miRNAs played core role in the progression of clear cell renal cell carcinoma (ccRCC). However, its molecular mechanism in ccRCC is still remained unclear. The study was designed to identify the role and regulatory mechanism of miR-582-5p in ccRCC. In this study, the low expression level of miR-582-5p were detected by qRT-PCR in ccRCC patient tumor samples and ccRCC cell lines, respectively. The expression level of miR-582-5p was associated with tumor stage and metastasis. In vivo and in vitro experiments found miR-582-5p inhibit tumor growth via suppressing COL5A1 expression. Additionally, RUNX1 was identified as the negative regulator of miR-582-5p through database prediction and chromatin immunoprecipitation. Finally, the negative relation of RUNX1 and miR-582-5p was verified through rescue experiment both in vitro and in vivo. In summary, miR-582-5p, which was regulated by RUNX1, inhibited tumor growth and invasion by targeting COL5A1, indicating that miR-582-5p may act as a biomarker and that the RUNX1/miR-582-5p/COL5A1 axis could be a potential therapeutic target for ccRCC.

HADHA overexpression disrupts lipid metabolism and inhibits tumor growth in clear cell renal cell carcinoma

2019 ◽  
Vol 384 (1) ◽  
pp. 111558 ◽  
Author(s):  
Shuai Liu ◽  
Xiaoli Liu ◽  
Fei Wu ◽  
Xufeng Zhang ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lipid Metabolism ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

MiR-137 suppresses tumor growth and metastasis in clear cell renal cell carcinoma

2018 ◽  
Vol 70 (5) ◽  
pp. 963-971 ◽  
Author(s):  
Meizhi Wang ◽  
Hui Gao ◽  
Haijun Qu ◽  
Jing Li ◽  
Kaili Liu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Growth ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Tumor Growth And Metastasis
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